Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Brian C. McCaughan"'
Autor:
Huaikai Shi, Emma M. Rath, Ruby C. Y. Lin, Kadir Harun Sarun, Candice Julie Clarke, Brian C. McCaughan, Helen Ke, Anthony Linton, Kenneth Lee, Sonja Klebe, Joanneke Maitz, Kedong Song, Yiwei Wang, Steven Kao, Yuen Yee Cheng
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments three-dimensio
Externí odkaz:
https://doaj.org/article/6d90a4a69dd34c658dbc9f753d07dc28
Autor:
Yuen Yee Cheng, Man Lee Yuen, Emma M. Rath, Ben Johnson, Ling Zhuang, Ta-kun Yu, Vesna Aleksova, Anthony Linton, Steven Kao, Candice Julie Clarke, Brian C. McCaughan, Ken Takahashi, Kenneth Lee
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
BackgroundThe diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty in distinguishing between MPM and reactive mesothelial hyperplasia (RMH). The tumor suppressor gene, CDKN2A, is frequently silenced by epi
Externí odkaz:
https://doaj.org/article/2be52171c2b04fd2bf21c40c1191cedd
Publikováno v:
Pathology. 53:930-933
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31085fefa67a66ebdef38825edbc86e
https://doi.org/10.1016/j.pathol.2021.01.016
https://doi.org/10.1016/j.pathol.2021.01.016
Autor:
Wendy A Cooper, Stephen Clarke, Tamkin Ahmadzada, Candice Clarke, Glen Reid, Brian C. McCaughan, Anthony Linton, Rebecca Asher, Kenneth Lee, Steven Kao
Publikováno v:
Lung Cancer. 130:35-41
A number of key immune regulators show prognostic value in malignant pleural mesothelioma (MPM), but the association between Bridging integrator 1 (BIN1), indoleamine 2,3 dioxygenase 1 (IDO1) and patient outcome has not been investigated. We aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca620261bfbdea13762f33074394594f
https://doi.org/10.1016/j.lungcan.2019.02.005
https://doi.org/10.1016/j.lungcan.2019.02.005
Publikováno v:
Biomedical Journal of Scientific & Technical Research. 26
Nucleic acid (DNA) extraction using a Formalin-Fixed Paraffin-Embedded (FFPE) block is a frequent practice in pathological diagnosis and medical research. The extracted nucleic acid, which is the targeted end-product for the further molecular genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f28d7cadc611147c3d63c25aaac42656
https://doi.org/10.26717/bjstr.2020.26.004335
https://doi.org/10.26717/bjstr.2020.26.004335
Autor:
Candice Julie Clarke, Ta-kun Yu, Emma M. Rath, Brian C. McCaughan, Kenneth Lee, Ben Johnson, Ling Zhuang, Man Lee Yuen, Ken Takahashi, Yiwei Wang, Anthony Linton, Yuen Yee Cheng, Steven Kao, K. Sarun
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10225, p 10225 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10225, p 10225 (2021)
Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective treatment options. Focal adhesion kinase (FAK) inhibitors have been shown to efficiently suppress MPM cell growth initially, with limited utility in the current c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c423a0511bad090d71528997579d3886
https://doi.org/10.3390/ijms221910225
https://doi.org/10.3390/ijms221910225
Autor:
Steven Kao, Juliet Burn, Catherine Kennedy, Jocelyn McLean, Tristan D. Yan, Brandon Lau, Brian C. McCaughan, Michael Boyer, Sanjeev Kumar
Publikováno v:
Web of Science
A small proportion of patients with malignant pleural mesothelioma (MPM) achieve pathological complete response (CR) following treatment with current practice induction chemotherapy. Our analysis of 58 patients with MPM treated with platinum-based ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99f484b332cc53fc7bf15ca5d01ec90
https://doi.org/10.1016/j.lungcan.2017.07.010
https://doi.org/10.1016/j.lungcan.2017.07.010
Autor:
Steven Kao, Marissa Williams, Michaela B. Kirschner, Nico van Zandwijk, K. Sarun, Brian C. McCaughan, Yuen Yee Cheng, Glen Reid, Patrick Winata, Karin Schelch
Publikováno v:
Oncotarget
MicroRNA downregulation is frequent in malignant pleural mesothelioma (MPM), but the mechanisms responsible for loss of miR-15/16 and miR-193a are yet to be elucidated and were investigated in this study. Copy Number Variation (CNV) of microRNA-codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61b6b95f3df13e178e26c417c1fc3a2
https://doi.org/10.5167/uzh-183486
https://doi.org/10.5167/uzh-183486
Autor:
Thang N Tran, Glen Reid, Nico van Zandwijk, Michael P. Vallely, Stephen Clarke, T. Korse, Nick Pavlakis, Michaela B. Kirschner, Mark P. Molloy, Sjaak Burgers, Daan van den Broek, J. James B. Edelman, Brian C. McCaughan, Wendy A Cooper, Casey M. Wright, Steven Kao
Publikováno v:
British Journal of Cancer
Background: We aimed to identify prognostic blood biomarkers using proteomics-based approaches in malignant pleural mesothelioma (MPM). Methods: Plasma samples from 12 MPM patients were used for exploratory mass spectrometry and ELISA analyses. The s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99af5c5def362c5bbaa930074ab9b304
http://europepmc.org/articles/PMC4782201
http://europepmc.org/articles/PMC4782201
Publikováno v:
Lung Cancer. 90:15-21
Background Access to specialist services may influence stage at cancer diagnosis and whether cancer is ever adequately staged. We investigated associations of distance to the nearest accessible specialist hospital (NASH) with likelihood of advanced o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89b356f812d9bdbcc47a26c17769e16
https://doi.org/10.1016/j.lungcan.2015.07.018
https://doi.org/10.1016/j.lungcan.2015.07.018