Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Brian C. Gilmour"'
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Akademický článek
High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists
Autor: Brian C. Gilmour, Alexandre Corthay, Inger Øynebråten
Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract The cytokine IL-12p70 is crucial for T helper 1 (Th1) polarization and the generation of type 1 immunity required to fight cancer and pathogens. Therefore, strategies to optimize the production of IL-12p70 by human dendritic cells (DCs) may
Externí odkaz: https://doaj.org/article/11169d30924549af9a3b3e8a61c709a5
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4
RNA-sensing pattern-recognition receptors synergize with TLR2 or dectin-1 to trigger high production of IL-12p70 by human dendritic cells
Autor: Brian C. Gilmour, Alexandre Corthay, Inger Øynebråten
IL-12p70 is crucial for T helper 1 polarization and the generation of type 1 immunity that is required to fight cancer and intracellular pathogens. Therefore, strategies to optimize the production of IL-12p70 by dendritic cells (DCs) may significantl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::784a8381a875b59c4dc7a0733ba79e64
https://doi.org/10.1101/2022.10.03.510527
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5
Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome
Autor: Domenica Caponio, Brian C. Gilmour, Sofie Lautrup, Tarjei H. Skjånes, Ruben Gudmundsrud, Evandro Fei Fang
Publikováno v: Cytogenet Genome Res
Werner syndrome (WS) is an accelerated ageing disease caused by multiple mutations in the gene encoding the Werner DNA helicase (WRN). The major clinical features of WS include wrinkles, grey hair, osteoporosis, and metabolic phenomena such as athero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e5df5028e9819ee7f50f4e9bc81423
https://doi.org/10.1159/000516386
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6
Elektronická kniha
Molecular, Cellular, and Metabolic Fundamentals of Human Aging
Autor: Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour
Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how i
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8
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Autor: Sofie Lautrup, Charalampos Tzoulis, Helge Røsjø, Ole-Bjørn Tysnes, Hilde Nilsen, Linda H. Bergersen, Jon Storm-Mathisen, Amund Hov, Brian C. Gilmour, Johannes Frank, Ruben Gudmundsrud, Evandro Fei Fang, Mathias Ziegler, Yahyah Aman, Charles Brenner, Arne Søraas, Torbjørn Omland, Trygve Holmøy
Publikováno v: Mechanisms of Ageing and Development
186:111208
Gilmour, B C, Gudmundsrud, R, Frank, J, Hov, A, Lautrup, S, Aman, Y, Rosjo, H, Brenner, C, Ziegler, M, Tysnes, O-B, Tzoulis, C, Omland, T, Soraas, A, Holmoy, T, Bergersen, L H, Storm-Mathisen, J, Nilsen, H & Fang, E F 2020, ' Targeting NAD + in translational research to relieve diseases and conditions of metabolic stress and ageing ', Mechanisms of Ageing and Development, vol. 186, 111208 . https://doi.org/10.1016/j.mad.2020.111208
Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to apoptosis and autophagic pathwa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd9d075042c209fb1899daab5d25ae3
https://hdl.handle.net/11250/2739150
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