Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Brian C. Evans"'
Autor:
Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide
Externí odkaz:
https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
Autor:
J. William Tierney, Brian C. Evans, Joyce Cheung-Flynn, Bo Wang, Juan M. Colazo, Monica E. Polcz, Rebecca S. Cook, Colleen M. Brophy, Craig L. Duvall
Publikováno v:
JCI Insight, Vol 6, Iss 19 (2021)
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migrator
Externí odkaz:
https://doaj.org/article/342ff646c4854f9ab16bc9c7e294d943
Autor:
Kyle M. Hocking, Craig L. Duvall, Padmini Komalavilas, Brian C. Evans, Colleen M. Brophy, Joyce Cheung-Flynn
Publikováno v:
Tissue Engineering Part A. 25:416-426
Subarachnoid hemorrhage (SAH) is associated with vasospasm that is refractory to pharmacologic intervention. SAH vasospasm is associated with decreased phosphorylation of intracellular heat shock protein (HSP)20 and increased phosphorylation of HSP27
Autor:
John William Tierney, Juan M. Colazo, Joyce Cheung-Flynn, Brian C. Evans, Kurt D. Hankenson, Kameron V. Kilchrist, Craig L. Duvall, Eric A. Dailing, Kedar Ghimire, Charles A. Gersbach, R. Brock Fletcher, Alvin J. Mukalel, Jeffrey S. Isenberg, Colleen M. Brophy, Cynthia Lander, Matthew J. Oliver
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate de
Autor:
Craig L. Duvall, Brian C. Evans, Jamal S. Lewis, Benjamin G. Keselowsky, Lawrence P. Fernando
Publikováno v:
Journal of Biomedical Materials Research Part A. 106:1022-1033
Poly(lactic-co-glycolic acid) (PLGA) is widely used as a vehicle for delivery of pharmaceutically relevant payloads. PLGA is readily fabricated as a nano- or microparticle (MP) matrix to load both hydrophobic and hydrophilic small molecular drugs as
Autor:
Kyle M. Hocking, Eric S. Wise, Joyce Cheung-Flynn, Colleen M. Brophy, Craig L. Duvall, Brian C. Evans
Publikováno v:
Perfusion. 32:489-494
Objectives: Unregulated intraoperative distension of human saphenous vein (SV) graft leads to supraphysiologic luminal pressures and causes acute physiologic and cellular injury to the conduit. The effect of distension on tissue viscoelasticity, a bi
Autor:
Meredith A. Jackson, Isom B. Kelly, Eric A. Dailing, Sean K. Bedingfield, Somtochukwu C. Dimobi, Brian C. Evans, Thomas A. Werfel, Craig L. Duvall, Kameron V. Kilchrist
Publikováno v:
ACS nano. 13(2)
Endolysosome entrapment is one of the key barriers to the therapeutic use of biologic drugs that act intracellularly. The screening of prospective nanoscale endosome-disrupting delivery technologies is currently limited by methods that are indirect a
Autor:
Corban Swain, Kameron V. Kilchrist, Craig L. Duvall, Thomas A. Werfel, Brian C. Evans, Christopher E. Nelson, Martina Miteva
Publikováno v:
Journal of Biomedical Materials Research Part A. 104:917-927
Hydrolytically degrading nano-polyplexes (HDG-NPs) that reverse charge through conversion of tertiary amines to carboxylic acids were investigated to improve intracellular un-packaging of siRNA and target gene silencing compared to a non-degradable a
Publikováno v:
Cellular and molecular bioengineering. 9(3)
Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase peptide uptake and intracell
Autor:
Kyle M. Hocking, Igor V. Voskresensky, Kameron V. Kilchrist, Colleen M. Brophy, Brian C. Evans, Michael J. Osgood, Julia Dmowska, Craig L. Duvall
Publikováno v:
Science Translational Medicine. 7
Autologous vein grafts are commonly used for coronary and peripheral artery bypass but have a high incidence of intimal hyperplasia (IH) and failure. We present a nanopolyplex (NP) approach that efficiently delivers a mitogen-activated protein kinase