Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Brian C Schaefer"'
Autor:
Kate E Mastraccio, Celeste Huaman, Si'Ana A Coggins, Caitlyn Clouse, Madeline Rader, Lianying Yan, Pratyusha Mandal, Imran Hussain, Anwar E Ahmed, Trung Ho, Austin Feasley, Bang K Vu, Ina L Smith, Wanda Markotter, Dawn L Weir, Eric D Laing, Christopher C Broder, Brian C Schaefer
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, pre‐symptomatic stage of
Externí odkaz:
https://doaj.org/article/f2f7561c73df4203a58b8d3978a4070c
Autor:
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1007986 (2021)
The adaptive immune system serves as a potent and highly specific defense mechanism against pathogen infection. One component of this system, the effector T cell, facilitates pathogen clearance upon detection of specific antigens by the T cell recept
Externí odkaz:
https://doaj.org/article/410e6f8f72684783986f3c0b857dcfc2
Autor:
Evalyne N. Wambugu, Gathii Kimita, Sarah N. Kituyi, Michael A. Washington, Clement Masakhwe, Lucy M. Mutunga, Gurdeep Jaswant, S.M. Thumbi, Brian C. Schaefer, John N. Waitumbi
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 8, Pp 1642-1650 (2024)
Rabies, a viral disease that causes lethal encephalitis, kills ≈59,000 persons worldwide annually, despite availability of effective countermeasures. Rabies is endemic in Kenya and is mainly transmitted to humans through bites from rabid domestic d
Externí odkaz:
https://doaj.org/article/840e5c4ac1794f689dd3a21b40626d7a
Autor:
Erika W Lamb, Colleen D Walls, John T Pesce, Diana K Riner, Sean K Maynard, Emily T Crow, Thomas A Wynn, Brian C Schaefer, Stephen J Davies
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000892 (2010)
Schistosoma blood flukes, which infect over 200 million people globally, co-opt CD4+ T cell-dependent mechanisms to facilitate parasite development and egg excretion. The latter requires Th2 responses, while the mechanism underpinning the former has
Externí odkaz:
https://doaj.org/article/867035dfed764de2b01162d60d8560f7
Autor:
Kariana E. Rios, Ming Zhou, Nathaniel M. Lott, Chelsi R. Beauregard, Dennis P. McDaniel, Thomas P. Conrads, Brian C. Schaefer
Publikováno v:
Cells, Vol 11, Iss 7, p 1175 (2022)
CARD19 is a mitochondrial protein of unknown function. While CARD19 was originally reported to regulate TCR-dependent NF-κB activation via interaction with BCL10, this function is not recapitulated ex vivo in primary murine CD8+ T cells. Here, we em
Externí odkaz:
https://doaj.org/article/8f981d76c573421587c0da605ad086c0
Autor:
Brian C. Schaefer
Publikováno v:
Gene Cloning and Analysis ISBN: 9781003421474
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f5e663e5acfc8cb341ea915974c0bf
https://doi.org/10.1201/9781003421474-7
https://doi.org/10.1201/9781003421474-7
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2524
Bioluminescence imaging (BLI) is a technique that can be employed to quantify biological processes in living cells. When used in small animal models such as mice, BLI can provide both longitudinal and positional information regarding the biological p
Publikováno v:
Bioluminescence ISBN: 9781071624524
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12e1ce939d0bbe021800fd77f6e00afb
https://doi.org/10.1007/978-1-0716-2453-1_30
https://doi.org/10.1007/978-1-0716-2453-1_30
Autor:
Alexandra DeLaney, Opher S. Kornfeld, Bettina L. Lee, Daniel P. Beiting, Eric M. Rodriguez Lopez, Petr Broz, Timothée Fettrelet, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Benjamin Demarco, Reyna Garcia Sillas, Elise Krespan, Kaiwen W. Chen, Igor E. Brodsky, Meghan A. Wynosky-Dolfi, Dorothy Tovar, Rina Matsuda, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.