Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Brian C Kraemer"'
Autor:
Aleen D Saxton, Brian C Kraemer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractAmyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused b
Externí odkaz:
https://doaj.org/article/894f4d49a5cc4bd7b313ea469f0bc990
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245962 (2021)
Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposi
Externí odkaz:
https://doaj.org/article/895a0ece70cf42ddbee160139b5c757c
Autor:
Nicole F Liachko, Aleen D Saxton, Pamela J McMillan, Timothy J Strovas, C Dirk Keene, Thomas D Bird, Brian C Kraemer
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008526 (2019)
Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43
Externí odkaz:
https://doaj.org/article/1cf101f9279c496eb2ae3aeb17d9fa07
Autor:
Sarah M. Waldherr, Marina Han, Aleen D. Saxton, Taylor A. Vadset, Pamela J. McMillan, Jeanna M. Wheeler, Nicole F. Liachko, Brian C. Kraemer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer’s disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPRER) tran
Externí odkaz:
https://doaj.org/article/1dbc62a4684b4673b78505934d8b0d3a
Autor:
Taylor R. Stanley, Elizabeth M. Otero, Amy L. Knight, Aleen D. Saxton, Xinxing Ding, Melissa Borgen, Brian C. Kraemer, Karen S. Kim Guisbert, Eric Guisbert
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/c5587db8194046bca5650410bfc4f688
Autor:
Nicole F Liachko, Pamela J McMillan, Timothy J Strovas, Elaine Loomis, Lynne Greenup, Jill R Murrell, Bernardino Ghetti, Murray A Raskind, Thomas J Montine, Thomas D Bird, James B Leverenz, Brian C Kraemer
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004803 (2014)
Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease. Kinase hyperactivity may be a consistent feature
Externí odkaz:
https://doaj.org/article/e84cb61b9288410cbcf053ad6da3a80d
Autor:
Kenji Dohi, Brian C Kraemer, Michelle A Erickson, Pamela J McMillan, Andrej Kovac, Zuzana Flachbartova, Kim M Hansen, Gul N Shah, Nader Sheibani, Therese Salameh, William A Banks
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108034 (2014)
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, pr
Externí odkaz:
https://doaj.org/article/f8d5b119e162484ba3c7a5eaff335b41
Autor:
Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106441- (2024)
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the prote
Externí odkaz:
https://doaj.org/article/2d36b23e4d484bf4a6f3f2d1918e850e
Autor:
Marina Han, Aleen Saxton, Heather Currey, Sarah M. Waldherr, Nicole F. Liachko, Brian C. Kraemer
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/9a227db882a241e29a42b610bf0b675f
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
The nematode Caenorhabditis elegans are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral, molec
Externí odkaz:
https://doaj.org/article/b2c4b137fffb423cbccbd3de9ef9b2a5