Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Brian C Kraemer"'
Autor:
Sarah M. Waldherr, Marina Han, Aleen D. Saxton, Taylor A. Vadset, Pamela J. McMillan, Jeanna M. Wheeler, Nicole F. Liachko, Brian C. Kraemer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer’s disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPRER) tran
Externí odkaz:
https://doaj.org/article/1dbc62a4684b4673b78505934d8b0d3a
Autor:
Taylor R. Stanley, Elizabeth M. Otero, Amy L. Knight, Aleen D. Saxton, Xinxing Ding, Melissa Borgen, Brian C. Kraemer, Karen S. Kim Guisbert, Eric Guisbert
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/c5587db8194046bca5650410bfc4f688
Autor:
Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106441- (2024)
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the prote
Externí odkaz:
https://doaj.org/article/2d36b23e4d484bf4a6f3f2d1918e850e
Autor:
Marina Han, Aleen Saxton, Heather Currey, Sarah M. Waldherr, Nicole F. Liachko, Brian C. Kraemer
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/9a227db882a241e29a42b610bf0b675f
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
The nematode Caenorhabditis elegans are a powerful model system to study human disease, with numerous experimental advantages including significant genetic and cellular homology to vertebrate animals, a short lifespan, and tractable behavioral, molec
Externí odkaz:
https://doaj.org/article/b2c4b137fffb423cbccbd3de9ef9b2a5
Autor:
Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phas
Externí odkaz:
https://doaj.org/article/dd6cabf3bab6402eb83b0235389e890a
Autor:
Caitlin S. Latimer, Jade G. Stair, Joshua C. Hincks, Heather N. Currey, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of patients with AD. Individuals with concomitant Aβ, tau and TDP-43 pathology
Externí odkaz:
https://doaj.org/article/5c050bf00fd142a8b69dd0b71acd12dc
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Accumulation of abnormal tau protein drives neurodegeneration in Alzheimer’s disease and related dementia disorders. Here, the authors demonstrate the endoplasmic reticulum unfolded protein response mediator XBP-1 controls pathological tau accumula
Externí odkaz:
https://doaj.org/article/b7f4bfc7537f47e98022e319db30674b
Autor:
Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird, C. Dirk Keene
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-24 (2019)
Abstract Alzheimer’s disease neuropathologic change (ADNC) is defined by progressive accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary tangles across diverse regions of brain. Non-demented individuals who reach a
Externí odkaz:
https://doaj.org/article/bc0a491ce3824f00984ecbed34fa9ee7
Autor:
Aleen D Saxton, Brian C Kraemer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractAmyotrophic lateral sclerosis (ALS) is a debilitating, fatal neurodegenerative disease that causes rapid muscle wasting. It shares a spectrum of symptoms and pathology with frontotemporal lobar degeneration (FTLD). These diseases are caused b
Externí odkaz:
https://doaj.org/article/894f4d49a5cc4bd7b313ea469f0bc990