Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Brian C, Monk"'
Autor:
Brian C. Monk, Prakhar Vijayvargiya, Mohamed Hassanein, Zackary A. Knott, Neville R. Dossabhoy, Yoshitsugu Obi
Publikováno v:
Renal Replacement Therapy, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Background Pantoea spp., a non-encapsulated, non-spore-forming Gram-negative rod bacterium that belongs to the Erwiniaceae family, can be found as a colonizer in humans, plants, and the environment, such as water and soil. Although it has th
Externí odkaz:
https://doaj.org/article/25f1964e47814a8cbbc1068a7ede4452
Publikováno v:
Journal of Fungi, Vol 10, Iss 10, p 698 (2024)
Limited antifungal treatment options and drug resistance require innovative approaches to effectively combat fungal infections. Combination therapy is a promising strategy that addresses these pressing issues by concurrently targeting multiple cellul
Externí odkaz:
https://doaj.org/article/d055cea199c044178ad2fdafd405e28e
Autor:
Stephanie Toepfer, Michaela Lackner, Mikhail V. Keniya, Lisa-Maria Zenz, Marianne Friemert, Franz Bracher, Brian C. Monk
Publikováno v:
Journal of Fungi, Vol 9, Iss 6, p 663 (2023)
Concern about the global emergence of multidrug-resistant fungal pathogens led us to explore the use of combination therapy to combat azole resistance in Candida auris. Clorgyline had previously been shown to be a multi-target inhibitor of Cdr1 and M
Externí odkaz:
https://doaj.org/article/e67914e645c049f9bffa68a50cd0ab71
Publikováno v:
Journal of Fungi, Vol 9, Iss 2, p 168 (2023)
Candida auris infections are difficult to treat due to acquired drug resistance against one or multiple antifungal drug classes. The most prominent resistance mechanisms in C. auris are overexpression and point mutations in Erg11, and the overexpress
Externí odkaz:
https://doaj.org/article/798ce1ba759747d7bdf7b956fb9d6deb
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1256 (2022)
Cryptococcus remains a leading cause of invasive fungal infections in immunocompromised people. Resistance to azole drugs has imposed a further challenge to the effective treatment of such infections. In this study, the functional expression of full-
Externí odkaz:
https://doaj.org/article/e9dbbfb0dbc14458adad81c0f3c0b9ba
Publikováno v:
Journal of Fungi, Vol 8, Iss 1, p 69 (2022)
The fungal cytochrome P450 lanosterol 14α-demethylase (CYP51) is required for the biosynthesis of fungal-specific ergosterol and is the target of azole antifungal drugs. Despite proven success as a clinical target for azole antifungals, there is an
Externí odkaz:
https://doaj.org/article/8861ba2508d547b8953aff0aa4a211c1
Autor:
Brian C. Monk, Mikhail V. Keniya
Publikováno v:
Journal of Fungi, Vol 7, Iss 12, p 1011 (2021)
In the original publication, there was a mistake [...]
Externí odkaz:
https://doaj.org/article/af63fdd115f94e9288a49255f0e73fe5
Autor:
Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Publikováno v:
Journal of Fungi, Vol 7, Iss 11, p 897 (2021)
Target-based azole resistance in Candida albicans involves overexpression of the ERG11 gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of Candida albicans LDM (CaLDM)
Externí odkaz:
https://doaj.org/article/2fb14a794e4d4733aafc6a6df72d6c0b
Autor:
Brian C. Monk, Mikhail V. Keniya
Publikováno v:
Journal of Fungi, Vol 7, Iss 2, p 67 (2021)
Antifungal drugs and antifungal agrochemicals have significant limitations. These include several unintended consequences of their use including the growing importance of intrinsic and acquired resistance. These problems underpin an increasingly urge
Externí odkaz:
https://doaj.org/article/3d852f5be8e64d26ad70e183677d9ce9
Publikováno v:
Journal of Fungi, Vol 7, Iss 2, p 68 (2021)
Multidrug resistance (MDR) transporters belonging to either the ATP-Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) groups are major determinants of clinical drug resistance in fungi. The overproduction of these proteins enables the ext
Externí odkaz:
https://doaj.org/article/b28ca69cc127468a8cab342d5e97d76b