Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brian Buttrick"'
Autor:
Frank R. Fronczek, Fanny Astruc-Diaz, Weize Huang, Charles M. Keyari, Brian Buttrick, Philippe Diaz, Lauren S L Price, Vanessa G. Sperandio, Nicolas Guilloteau, Nina Isoherranen, Sasmita Tripathy
Publikováno v:
Journal of Medicinal Chemistry. 59:2579-2595
Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance. Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an attractive therapeutic target. However, the selectivity and potency of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae645ad616cc638a43f95816ad6d484
https://doi.org/10.1021/acs.jmedchem.5b01780
https://doi.org/10.1021/acs.jmedchem.5b01780
Autor:
Robert S. Foti, Alex Zelter, Leslie J. Dickmann, Brian Buttrick, Nina Isoherranen, Philippe Diaz, Dominique Douguet
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2016, 357 (2), pp.281-292. ⟨10.1124/jpet.116.232637⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2016, 357 (2), pp.281-292. ⟨10.1124/jpet.116.232637⟩
Cytochrome P450 (CYP) 26A1 and 26B1 are heme-containing enzymes responsible for metabolizing all-trans retinoic acid (at-RA). No crystal structures have been solved, and therefore homology models that provide structural information are extremely valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e2247b979ac815973d0d2183256c7b
https://doi.org/10.1124/jpet.116.232637
https://doi.org/10.1124/jpet.116.232637
Autor:
Josh T. Pearson, Robert S. Foti, Abhinav Nath, William M. Atkins, Nina Isoherranen, Matthew T. Honaker, Brian Buttrick
Publikováno v:
Biochemistry. 50:2387-2393
Promiscuity at the molecular level plays a critical role in several cellular processes including signal transduction, immunity, and detoxification (1–9). More broadly, the evolution of new enzymatic activities from a pool of existing protein scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4758e44ec4a27d9852739f40121053
https://doi.org/10.1021/bi1020716
https://doi.org/10.1021/bi1020716
Publikováno v:
Current topics in medicinal chemistry. 13(12)
Retinoic acid (RA), the active metabolite of vitamin A, is an important endogenous signaling molecule regulating cell cycle and maintenance of epithelia. RA isomers are also used as drugs to treat various cancers and dermatological diseases. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d097aab059f1054972d1ffc27d469cc
https://pubmed.ncbi.nlm.nih.gov/23688132
https://pubmed.ncbi.nlm.nih.gov/23688132