Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brian Budke"'
Autor:
Susan L. Cohn, Philip P. Connell, Yusuke Nakamura, Emma Wilkinson, Mark A. Applebaum, Ryan Miller, Jae-Hyun Park, Brian Budke, Helen R. Salwen, Marija Dobratic, Chanyoung Park, Alexandre Chlenski
MYCN/MYC expression in N-type and S-type neuroblastoma cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03019b2e4e013bb650ca3b7c2f1f466a
https://doi.org/10.1158/1535-7163.22507038.v1
https://doi.org/10.1158/1535-7163.22507038.v1
Autor:
Susan L. Cohn, Philip P. Connell, Yusuke Nakamura, Emma Wilkinson, Mark A. Applebaum, Ryan Miller, Jae-Hyun Park, Brian Budke, Helen R. Salwen, Marija Dobratic, Chanyoung Park, Alexandre Chlenski
Maternal embryonic leucine zipper kinase (MELK) activates pathways that mediate aggressive tumor growth and therapy resistance in many types of adult cancers. Pharmacologic and genomic inhibition of MELK impairs tumor growth and increases sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4febb23c7b71f32373ae7d55f84061a
https://doi.org/10.1158/1535-7163.c.6538560.v1
https://doi.org/10.1158/1535-7163.c.6538560.v1
Autor:
Susan L. Cohn, Philip P. Connell, Yusuke Nakamura, Emma Wilkinson, Mark A. Applebaum, Ryan Miller, Jae-Hyun Park, Brian Budke, Helen R. Salwen, Marija Dobratic, Chanyoung Park, Alexandre Chlenski
pRPA32 expression in neuroblastoma cells treated with OTS167 and CPT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58ba688ff09dc1f2df1acdca3bfff2b
https://doi.org/10.1158/1535-7163.22507032
https://doi.org/10.1158/1535-7163.22507032
Autor:
Susan L. Cohn, Philip P. Connell, Yusuke Nakamura, Emma Wilkinson, Mark A. Applebaum, Ryan Miller, Jae-Hyun Park, Brian Budke, Helen R. Salwen, Marija Dobratic, Chanyoung Park, Alexandre Chlenski
MELK and EZH2 RNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a748e7b00f5b7ddeeccda910c3a1d
https://doi.org/10.1158/1535-7163.22507035.v1
https://doi.org/10.1158/1535-7163.22507035.v1
Autor:
Philip P. Connell, Douglas K. Bishop, Alan P. Kozikowski, Ralph R. Weichselbaum, Michal Pawlowski, Megan Wu, Brian Budke, Hillary L. Logan, Jennifer M. Mason
PDF file - 403KB, Supplemental Figure 1. Quantifications of western blots. Supplemental Figure 2. Knockdown of RAD51 in PC3 does not protect cells from the toxicity of ionizing radiation. Supplemental Table 1. Quantifications of statistical significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a223739e1eb3f6749cbadfa26475bef
https://doi.org/10.1158/0008-5472.22399215
https://doi.org/10.1158/0008-5472.22399215
Autor:
Brian Budke, Alison Zhong, Katherine Sullivan, Chanyoung Park, David I Gittin, Timothy S Kountz, Philip P Connell
Publikováno v:
Nucleic acids research. 50(11)
Homologous recombination (HR) serves multiple roles in DNA repair that are essential for maintaining genomic stability, including double-strand DNA break (DSB) repair. The central HR protein, RAD51, is frequently overexpressed in human malignancies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e719a655927fe2082d9a1f2139a63f4d
https://pubmed.ncbi.nlm.nih.gov/35689636
https://pubmed.ncbi.nlm.nih.gov/35689636
Publikováno v:
ChemMedChem
RAD51 is the central protein in homologous recombination (HR) repair, where it first binds ssDNA and then catalyzes strand invasion via a D-loop intermediate. Additionally, RAD51 plays a role in faithful DNA replication by protecting stalled replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fae57c63b9cec8ca2377346f670e26
https://doi.org/10.1002/cmdc.201900075
https://doi.org/10.1002/cmdc.201900075
Autor:
Alexandre Chlenski, Emma Wilkinson, Marija Dobratic, Chanyoung Park, Yusuke Nakamura, Ryan Miller, Brian Budke, Susan L. Cohn, Jae-Hyun Park, Mark A. Applebaum, Philip P. Connell, Helen R. Salwen
Publikováno v:
Molecular Cancer Therapeutics. 18:507-516
Maternal embryonic leucine zipper kinase (MELK) activates pathways that mediate aggressive tumor growth and therapy resistance in many types of adult cancers. Pharmacologic and genomic inhibition of MELK impairs tumor growth and increases sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1834223a35d92ea120d1663de41e9d13
https://doi.org/10.1158/1535-7163.mct-18-0819
https://doi.org/10.1158/1535-7163.mct-18-0819
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 111:e229-e230
Purpose/objective(s) Homologous recombination (HR) provides repair of DNA double stranded breaks and lesion that block DNA replication. While non-homologous end joining (NHEJ) proficiency is commonly attributed to tumor cell resistance to radiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cd7411599a81f461598078e78f3bd3
https://doi.org/10.1016/j.ijrobp.2021.07.787
https://doi.org/10.1016/j.ijrobp.2021.07.787
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 108:e545
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48baaeac16fcd0c4d8d33576127c716b
https://doi.org/10.1016/j.ijrobp.2020.07.1697
https://doi.org/10.1016/j.ijrobp.2020.07.1697