Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Brian Billups"'
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 819 (2023)
D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurotransmitter glutamate. Despite its involvement in plasticity and memory related to excitatory sy
Externí odkaz:
https://doaj.org/article/ef4db03cb7bf4e1f83998912c1188775
Publikováno v:
Glia. 65:900-916
The release of glutamine from astrocytes adjacent to synapses in the central nervous system is thought to play a vital role in the mechanism of glutamate recycling and is therefore important for maintaining excitatory neurotransmission. Here we inves
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 4, p 924 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 924
International Journal of Molecular Sciences, Vol 19, Iss 4, p 924 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 924
Astrocytes are glial cells that have an intimate physical and functional association with synapses in the brain. One of their main roles is to recycle the neurotransmitters glutamate and gamma-aminobutyric acid (GABA), as a component of the glutamate
Publikováno v:
Journal of Neuroscience Research. 93:1031-1044
Glutamate released from synapses during excitatory neurotransmission must be rapidly recycled to maintain neuronal communication. This review evaluates data from physiological experiments at hippocampal CA3 to CA1 synapses and the calyx of Held synap
Publikováno v:
The Journal of Neuroscience. 33:17429-17434
The mechanisms by which the excitatory neurotransmitter glutamate is recycled at synapses are currently unknown. By examining the functional expression of plasma membrane transporters at presynaptic terminals, we aim to elucidate some of the mechanis
Publikováno v:
Glia. 65(6)
The release of glutamine from astrocytes adjacent to synapses in the central nervous system is thought to play a vital role in the mechanism of glutamate recycling and is therefore important for maintaining excitatory neurotransmission. Here we inves
Publikováno v:
The Journal of Physiology. 590:2317-2331
Key points • Following release of glutamate from excitatory synapses, excitatory amino acid transporters (EAATs) sequester this glutamate into neighbouring astrocytes. • The signalling effects on the astrocyte and the mechanisms by which this glu
Autor:
Mona Bjørkmo, Daniela Billups, N.M. Uwechue, Antonin Blot, A.Z. Quazi, Brian Billups, Farrukh A. Chaudhry
Publikováno v:
Neuroscience
Glutamine plays multiple roles in the CNS, including metabolic functions and production of the neurotransmitters glutamate and GABA. It has been proposed to be taken up into neurons via a variety of membrane transport systems, including system A, whi
Publikováno v:
Journal of Neuroscience Methods
Electroporation creates transient pores in the plasma membrane to introduce macromolecules within a cell or cell population. Generally, electrical pulses are delivered between two electrodes separated from each other, making electroporation less like
Publikováno v:
Glia. 64(10)
The transmembrane Na(+) concentration gradient is an important source of energy required not only to enable the generation of action potentials in excitable cells, but also for various transmembrane transporters both in excitable and non-excitable ce