Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Brian B. Lee"'
Autor:
Kristin M. Zimmerman Savill, Brian B. Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W. Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E. Martin, Deepak Sampath, Kui Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How resistance to different classes of AKT inhibitors can emerge is unclear. Here, the authors show that resistance to allosteric inhibitors is mainly due to mutation of AKT1 while the ATP competitive resistance is driven by activation of PIM kinases
Externí odkaz:
https://doaj.org/article/942eedd4f9f14214ba862fbc21b1991f
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e28628965bd5c2946f0b8f30a83eb4
https://doi.org/10.1158/1078-0432.22455131.v1
https://doi.org/10.1158/1078-0432.22455131.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
Purpose: We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical trials for the treatment of human cancers.Experimental Design: The effect of GDC-00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83abf89be72a90f834045029a21f1a26
https://doi.org/10.1158/1078-0432.c.6522932.v1
https://doi.org/10.1158/1078-0432.c.6522932.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
PDF file - 954K, Supplemental Figures: Figure S1. Chemical structure of the Akt inhibitor GDC-0068. Figure S2. Effect of GDC-0068 on cell cycle and apoptotic response on PC-3 and MCF7-neo/HER2 cell lines. Figure S3. Western blot analysis of indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091abdb4dab0760c8b3bb36517167f0f
https://doi.org/10.1158/1078-0432.22455134.v1
https://doi.org/10.1158/1078-0432.22455134.v1
Autor:
Kui Lin, Lori S. Friedman, Elizabeth Punnoose, Marcia Belvin, Jeffrey J. Wallin, Nicholas J. Skelton, Hartmut Koeppen, Bianca M. Liederer, Stefan Gross, Tyler Risom, Leslie B. Lee, Robert Kassees, Rebecca Hong, Zhengyu Guan, Heidi Savage, Jason Oeh, Michael Degtyarev, Brian B. Lee, Michelle A. Nannini, Deepak Sampath, Jie Lin
XLSX file - 74K, Table S1. Enzymatic potency, selectivity and cellular potency of GDC-0068 Table S2. GDC-0068 IC50 profile on cell viability and genetic background of cancer cell lines Table S3. Maximum percent body weight changes of mice treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756d1ee5c841699c909d697cac554d96
https://doi.org/10.1158/1078-0432.22455128.v1
https://doi.org/10.1158/1078-0432.22455128.v1
Autor:
Brian B. Lee, Larry W. Lake
Publikováno v:
Day 3 Wed, September 30, 2015.
There are many public and private databases of oil field properties the analysis of which could lead to insights in several areas. Recent trend of Big Data has given rise to novel analytic methods to effectively handle multidimensional data, and to v
Autor:
Tom D. Bennett, Michael J. Kallok, Mark Erickson, James W. Leitch, William J. Combs, Brian B. Lee, George Klein, Raymond Yee
Publikováno v:
Pacing and Clinical Electrophysiology. 15:2232-2235
Conventional Holter monitoring is of limited benefit in patients with infrequent symptoms suspected to be related to arrhythmia. A small recorder implanted subcutaneously might obviate many limitations of conventional monitoring. To determine the fea
Autor:
Dimitry Bosoy, Brian B. Lee
Publikováno v:
The Journal of Emergency Medicine. 43:710-711
A 55-year-old woman with a past medical history of hypertension presented to the Emergency Department after suffering a fall. She reported falling from a standing position while attempting to hoist a garbage bag into a dumpster; she landed on her but
Publikováno v:
Heart Rhythm. 3:S206
Autor:
Brian B. Lee
Publikováno v:
The Journal of the Acoustical Society of America. 120:1772
A minimally invasive, implantable monitor and associated method for chronically monitoring a patient's hemodynamic function based on signals sensed by one or more acoustical sensors. The monitor may be implanted subcutaneously or submuscularly in rel