Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Brian B. Gowen"'
Autor:
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV
Externí odkaz:
https://doaj.org/article/b9951ffe5c244d7b912906b85005d70b
Autor:
Brady T. Hickerson, Tracy R. Daniels-Wells, Cristian Payes, Lars E. Clark, Pierre V. Candelaria, Kevin W. Bailey, Eric J. Sefing, Samantha Zink, James Ziegenbein, Jonathan Abraham, Gustavo Helguera, Manuel L. Penichet, Brian B. Gowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Five New World mammarenaviruses (NWMs) enter cells via binding to human transferrin receptor 1 (hTfR1). Here, Hickerson et al. show that hTfR1 targeting antibodies partially protect hTfR1-transgenic mice from lethal NWM challenge via competition of a
Externí odkaz:
https://doaj.org/article/e61379f33d29440ab73ec6d55d625606
Autor:
Kyle Rosenke, Heinz Feldmann, Jonna B. Westover, Patrick William Hanley, Cynthia Martellaro, Friederike Feldmann, Greg Saturday, Jamie Lovaglio, Dana P. Scott, Yousuke Furuta, Takashi Komeno, Brian B. Gowen, David Safronetz
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 9, Pp 1696-1699 (2018)
Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection. We tested favipiravir in Lassa virus
Externí odkaz:
https://doaj.org/article/3aecf98e94ba4838974e7b84ddf68363
Autor:
Brian B. Gowen, Jane Ennis, Kevin W. Bailey, Zachary Vest, Dionna Scharton, Eric J. Sefing, Jeffrey D. Turner
Publikováno v:
Viruses, Vol 6, Iss 3, Pp 1410-1423 (2014)
Rift Valley fever virus (RVFV) causes severe disease in humans and ungulates. The virus can be transmitted by mosquitoes, direct contact with infected tissues or fluids, or aerosol, making it a significant biological threat for which there is no appr
Externí odkaz:
https://doaj.org/article/bb52ff433d11430cad2c3f4ac8eccb7e
Autor:
Jonna B. Westover, Brady T. Hickerson, Arnaud J. Van Wettere, Brett L. Hurst, Jacqueline P. Kurz, Ashley Dagley, Petra Wülfroth, Takashi Komeno, Yousuke Furuta, Thomas Steiner, Brian B. Gowen
Publikováno v:
Pathogens, Vol 8, Iss 4, p 158 (2019)
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the pathogenesis and natural history of disease in IFNAR-/- mice challenged with t
Externí odkaz:
https://doaj.org/article/d62fed5b2b274856bc5f917b9cf0cdd7
Autor:
Brady T. Hickerson, Jonna B. Westover, Arnaud J. Van Wettere, Johanna D. Rigas, Jinxin Miao, Bettina L. Conrad, Neil E. Motter, Zhongde Wang, Brian B. Gowen
Publikováno v:
Viruses, Vol 10, Iss 11, p 651 (2018)
Rift Valley fever virus (RVFV) is an emerging pathogen capable of causing severe disease in livestock and humans and can be transmitted by multiple routes including aerosol exposure. Several animal models have been developed to gain insight into the
Externí odkaz:
https://doaj.org/article/01331e20e29e452abba7fecf6a5fad84
Autor:
Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris
Publikováno v:
ACS Medicinal Chemistry Letters. 14:506-513
Autor:
Jonna B. Westover, Shibani Naik, Kevin W. Bailey, Luci Wandersee, Vidyasagar R. Gantla, Brady T. Hickerson, Ken McCormack, Greg Henkel, Brian B. Gowen
Publikováno v:
Antiviral Res
Infections by pathogenic New World mammarenaviruses (NWM)s, including Junín virus (JUNV), can result in a severe life-threatening viral hemorrhagic fever syndrome. In the absence of FDA-licensed vaccines or antivirals, these viruses are considered h
Autor:
Douglas M. Watts, Jonna L.B. Westover, Pedro M. Palermo, Kevin W. Bailey, John C. Morrill, George E. Bettinger, Thomas P. Monath, Darci R. Smith, Clarence J. Peters, Phillip R. Pittman, Jeanette Orbegozo, Brian B. Gowen
Publikováno v:
The American journal of tropical medicine and hygiene. 107(5)
The Rift Valley fever virus (RVFV) MP-12 vaccine is a promising human and veterinary vaccine. Although the vaccine elicited neutralizing antibody (nAb) in human volunteers, the minimal antibody titer that is needed to afford protection is unknown. Th
Autor:
Brianne Roper, Dallan J. Blotter, Paul Bates, Kirsten M Boardman, Brian B. Gowen, Jonna B. Westover, Tomaz B Manzoni, Phillip Hicks, Gabrielle L Rock
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently emerged tickborne virus in east Asia with over 8,000 confirmed cases. With a high case fatality ratio, SFTSV has been designated a high priority pathogen by the WHO and the NIAID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a52c94641485e518dcdf50eb81a49d
https://doi.org/10.1101/2021.11.29.470508
https://doi.org/10.1101/2021.11.29.470508