Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Brian B, Haines"'
Autor:
Edward M. Kennedy, Agnieszka Denslow, Jacqueline Hewett, Lingxin Kong, Ana De Almeida, Jeffrey D. Bryant, Jennifer S. Lee, Judy Jacques, Sonia Feau, Melissa Hayes, Elizabeth L. McMichael, Daniel Wambua, Terry Farkaly, Amal A Rahmeh, Lauren Herschelman, Danielle Douglas, Jacob Spinale, Sanmit Adhikari, Jessica Deterling, Matt Scott, Brian B. Haines, Mitchell H. Finer, Ted T Ashburn, Christophe Quéva, Lorena Lerner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The development of neutralizing antibodies can limit the therapeutic effectiveness of systemically administered oncolytic viruses (OV). Here, to enable repeated intravenous administration, the authors report the development of synthetic RNA viruses f
Externí odkaz:
https://doaj.org/article/e35ea397d9ba41b5b30d0dfa85eb8713
Autor:
Edward M. Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, Jacqueline Hewett, Jeffrey Bryant, Prajna Behara, Caitlin Goshert, Daniel Wambua, Ana De Almeida, Judith Jacques, Damian Deavall, James B. Rottman, Joseph C. Glorioso, Mitchell H. Finer, Brian B. Haines, Christophe Quéva, Lorena Lerner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 476-490 (2020)
Development of next-generation oncolytic viruses requires the design of vectors that are potently oncolytic, immunogenic in human tumors, and well tolerated in patients. Starting with a joint-region deleted herpes simplex virus 1 (HSV-1) to create la
Externí odkaz:
https://doaj.org/article/b74418f2850d47de82488eefe949e024
Autor:
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Cristina St. Pierre, Pranal J Dakle, Vincenzo Pucci, James Baker, Andrey Loboda, Doug Linn, Christopher Brynczka, Doug Wilson, Brian B Haines, Brian Long, Richard Wnek, Svetlana Sadekova, Michael Rosenzweig, Andrew Haidle, Yongxin Han, Sheila H. Ranganath
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP recep
Externí odkaz:
https://doaj.org/article/36e7a55740434d6e88a502ce5e86b72a
Autor:
Christophe Quéva, Lorena Lerner, Edward M. Kennedy, Sonia Feau, Melissa W. Hayes, Mitchel H. Finer, Allison Colthart, Michael Ball, Caitlin Goshert, Judith Jacques, Prajna Behera, Lingxin Kong, Daniel Wambua, Jacqueline Hewett, Terry Farkaly, Jennifer S. Lee, Peter Grzesik, Agnieszka Denslow, Brian B. Haines
Supplemental Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfb51c9f36daf3b0ec0c09daa990df8
https://doi.org/10.1158/2326-6066.22543431.v1
https://doi.org/10.1158/2326-6066.22543431.v1
Autor:
Christophe Quéva, Lorena Lerner, Edward M. Kennedy, Sonia Feau, Melissa W. Hayes, Mitchel H. Finer, Allison Colthart, Michael Ball, Caitlin Goshert, Judith Jacques, Prajna Behera, Lingxin Kong, Daniel Wambua, Jacqueline Hewett, Terry Farkaly, Jennifer S. Lee, Peter Grzesik, Agnieszka Denslow, Brian B. Haines
ONCR-177 is an engineered recombinant oncolytic herpes simplex virus (HSV) with complementary safety mechanisms, including tissue-specific miRNA attenuation and mutant UL37 to inhibit replication, neuropathic activity, and latency in normal cells. ON
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6663d25128f50d686dbfb13f50074
https://doi.org/10.1158/2326-6066.c.6550257.v1
https://doi.org/10.1158/2326-6066.c.6550257.v1
Autor:
Sriram Sathyanarayanan, Jon C. Aster, X. Shirley Liu, Warren S. Pear, Bradley E. Bernstein, Birgit Knoechel, Brandon E. Kremer, Theresa Zhang, Gary Gilliland, Stephen Fawell, Leigh Zawel, Christopher Moskaluk, Brian B. Haines, Jason Laskey, Michael Kluk, Philip W. Garrett-Engele, John MacLean, Chris Ware, Jing Yuan, Chongzhi Zang, Hongfang Wang, Li Pan, Andrew Truong, Serguei Lejnine, Alexander Stoeck
human Breast tumor Notch gene coverage annotations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772c70e0961cfb13b051a4fed2d019a3
https://doi.org/10.1158/2159-8290.22529885.v1
https://doi.org/10.1158/2159-8290.22529885.v1
Autor:
Christopher P. Leamon, Isabelle Dussault, Emmett V. Schmidt, Kristen L. Picard, Andrey Loboda, Theresa Zhang, Michael Nebozhyn, Serguei Lejnine, Marilynn Vetzel, Melissa Nelson, Alicia Bloomfield, Ryan Dorton, Marlene C. Hinton, Brian B. Haines, Razvan Cristescu, Joseph A. Reddy, Alexander Stoeck, Jennifer O'Neil, Amy D. Guertin
Supplementary Figure 1: Assessment of kidney cancer cell lines A498, 786-O, and A704 via flow cytometry revealed surface expression of P-gp in all lines; Supplementary Figure 2: 786-O and A704 cells were transduced with lentiviral FR1, and flow cytom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b3ef96e0e06a8b39939d2f61b13772
https://doi.org/10.1158/1535-7163.22508953
https://doi.org/10.1158/1535-7163.22508953
Autor:
Sriram Sathyanarayanan, Jon C. Aster, X. Shirley Liu, Warren S. Pear, Bradley E. Bernstein, Birgit Knoechel, Brandon E. Kremer, Theresa Zhang, Gary Gilliland, Stephen Fawell, Leigh Zawel, Christopher Moskaluk, Brian B. Haines, Jason Laskey, Michael Kluk, Philip W. Garrett-Engele, John MacLean, Chris Ware, Jing Yuan, Chongzhi Zang, Hongfang Wang, Li Pan, Andrew Truong, Serguei Lejnine, Alexander Stoeck
S1: NOTCH gene rearrangement in breast cancer cell lines and human breast tumors. S2: NOTCH gene rearrangement and sensitivity to MRK-003. S3: HES4 expression is associated with NOTCH gene-rearrangement or activating mutation in NOTCH. S4: HES4 expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7e587c75653d144fc20a17c000c13a
https://doi.org/10.1158/2159-8290.22529894.v1
https://doi.org/10.1158/2159-8290.22529894.v1
Autor:
Sriram Sathyanarayanan, Jon C. Aster, X. Shirley Liu, Warren S. Pear, Bradley E. Bernstein, Birgit Knoechel, Brandon E. Kremer, Theresa Zhang, Gary Gilliland, Stephen Fawell, Leigh Zawel, Christopher Moskaluk, Brian B. Haines, Jason Laskey, Michael Kluk, Philip W. Garrett-Engele, John MacLean, Chris Ware, Jing Yuan, Chongzhi Zang, Hongfang Wang, Li Pan, Andrew Truong, Serguei Lejnine, Alexander Stoeck
File includes genomic analysis, cell cycle and cell proliferation analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be61200c03fe3c0610304a985d3928e9
https://doi.org/10.1158/2159-8290.22529891.v1
https://doi.org/10.1158/2159-8290.22529891.v1
Autor:
Stuart D. Shumway, Andrew Bloecher, Theresa Zhang, Christopher Winter, Brian B. Haines, Razvan Cristescu, William Arthur, Andrey Loboda, Serguei Lejnine, Astrid Kral, Jing Li, Yaping Liu, Brian Roberts, Melissa Chenard, Igor Feldman, Yair Benita, Jennifer O'Neil
Supplementary figure, table and data legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d5da00a1ff6efad42d8684cfdb08a
https://doi.org/10.1158/1535-7163.22503118
https://doi.org/10.1158/1535-7163.22503118