Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Brian B, Graham"'
Autor:
Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal rol
Externí odkaz:
https://doaj.org/article/c4fa6ee4bd3349f19baf5bada146c57a
Autor:
Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. Stenmark
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionHypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary interstitial macrophages (IMs) play pivotal roles in immune and vascular dysfunction, l
Externí odkaz:
https://doaj.org/article/ff6beb390653433dbe01318df19ac657
Autor:
Biruk Kassa, Dara C. Fonseca‐Balladares, Rahul Kumar, Michael H. Lee, Claudia Mickael, Linda Sanders, Kevin Nolan, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Whether all Schistosoma species cause pulmonary hypertension (PH) is unclear. Experimentally exposing mice to Schistosoma haematobium eggs caused PH, which was less severe than that induced by S. mansoni exposure. These findings align with t
Externí odkaz:
https://doaj.org/article/46ef8c2b319c48a4b72d155414d53fe3
Autor:
Brian B. Graham, Joan F. Hilton, Michael H. Lee, Rahul Kumar, Dara Fonseca Balladares, Farbod N. Rahaghi, Raúl San José Estépar, Claudia Mickael, Rodrigo Luís Barbosa Lima, Camila M.C. Loureiro, Juliana Lucena, Rudolf K.F. Oliveira, Ricardo de Amorim Corrêa
Publikováno v:
JHLT Open, Vol 1, Iss , Pp 100007- (2023)
Pulmonary arterial hypertension associated with schistosomiasis (SchPAH) and pulmonary arterial hypertension associated with portal hypertension (PoPAH) are lung diseases that develop in the presence of liver diseases. However, mechanistic pathways b
Externí odkaz:
https://doaj.org/article/3299026feb594a1cb3780fc79b26ce21
Autor:
Rahul Kumar, Öznur Aktay-Cetin, Vaughn Craddock, Daniel Morales-Cano, Djuro Kosanovic, Angel Cogolludo, Francisco Perez-Vizcaino, Sergey Avdeev, Ashok Kumar, Anil Kumar Ram, Stuti Agarwal, Ananya Chakraborty, Rajkumar Savai, Vinicio de Jesus Perez, Brian B Graham, Ghazwan Butrous, Navneet K Dhillon
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011063 (2023)
The Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its sublineages pose a new challenge to healthcare systems worldwide due to its ability to efficiently spread in immunized populations
Externí odkaz:
https://doaj.org/article/9b110a173dd444aebc53dc7fefe8314d
Autor:
Michael H. Lee, Thaís C. F. Menezes, Julie A. Reisz, Eloara V. M. Ferreira, Brian B. Graham, Rudolf K. F. Oliveira
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Pulmonary arterial hypertension is an incurable disease marked by dysregulated metabolism, both at the cellular level in the pulmonary vasculature, and at the whole-body level characterized by impaired exercise oxygen consumption. Though both altered
Externí odkaz:
https://doaj.org/article/795a395e5114404493146bab8c48b38b
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0
Autor:
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/f75ae1b920ed4388b4b98edd05c4de18
Autor:
Neha Chanana, Tsering Palmo, Kavita Sharma, Rahul Kumar, Bhushan Shah, Sudhanshu Mahajan, Girish M. Palleda, Mohit D. Gupta, Ritushree Kukreti, Mohammad Faruq, Tashi Thinlas, Brian B. Graham, Qadar Pasha
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Dexamethasone can be taken prophylactically to prevent hypobaric hypoxia-associated disorders of high-altitude. While dexamethasone-mediated protection against high-altitude disorders has been clinically evaluated, detailed sex-based mechanistic insi
Externí odkaz:
https://doaj.org/article/6153d6aea2f74a8783a61c412dcb0cbe
Autor:
Edford Sinkala, Hanan Yusuf Ahmed, Jean Pierre Sibomana, Michael H. Lee, Biruk Kassa, Rahul Kumar, Sula Mazimba, Amsalu B. Binegdie, Sydney Mpisa, Kawana Wamundila, Brian B. Graham, Joan F. Hilton
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH) worldwide, but the prevalence and risk factors for schistosomiasis‐associated PAH (SchPAH) development are not well understood. Schistosomiasis‐associated hepatosp
Externí odkaz:
https://doaj.org/article/13a2bfdef47c4bb5adde14a1d0354d8e