Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Brian Austad"'
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0b6f0e62a97eb1ab238ef7f2117e0
https://doi.org/10.1055/s-0032-1317920
https://doi.org/10.1055/s-0032-1317920
Autor:
Hirofumi Kuroda, Huiming Zhang, Yuki Komatsu, Naoki Asakawa, Yongbo Hu, Akio Kayano, Takashi Hasebe, Takashi Kajima, Xiang Niu, Yorihisa Hoshino, Charles E. Chase, Francis G. Fang, Tomohiro Watanabe, Hiroyuki Ishizuka, Thomas Noland, Matthew J. Schnaderbeck, Thomas E. Horstmann, Naoki Asai, Mamoru Miyazawa, Katsuya Tagami, Brian Austad, Manabu Kubota, John D. Orr, Trevor Lee Calkins, Hiroyuki Chiba, Bryan M. Lewis
Publikováno v:
Synlett. 24:333-337
The evolution of the synthesis of Halaven® (E7389, INN eribulin mesylate) from a medicinal chemistry process to the execution of the final process on pilot scale is described. The completion of the synthesis of Halaven® from C1–C13 ester and C14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd614ef0861f50badf9f4d38d2284d9
https://doi.org/10.1055/s-0032-1318026
https://doi.org/10.1055/s-0032-1318026