Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Brian Akhaphong"'
1
Akademický článek
Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice
Autor: Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Publikováno v: Frontiers in Endocrinology, Vol 12 (2022)
The risk of obesity in adulthood is subject to programming in the womb. Maternal obesity contributes to programming of obesity and metabolic disease risk in the adult offspring. With the increasing prevalence of obesity in women of reproductive age t
Externí odkaz: https://doaj.org/article/277f63bd9df249f2b439a8696c2ffd74
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2
Akademický článek
Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass
Autor: Alicia Wong, Brian Akhaphong, Daniel Baumann, Emilyn U. Alejandro
Publikováno v: Biomedicines, Vol 11, Iss 1, p 105 (2022)
Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKOPanc) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore
Externí odkaz: https://doaj.org/article/2879a5dc9b28497b9939db1a83c03487
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3
Akademický článek
Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice
Autor: Brian Akhaphong, Daniel C. Baumann, Megan Beetch, Amber D. Lockridge, Seokwon Jo, Alicia Wong, Tate Zemanovic, Ramkumar Mohan, Danica L. Fondevilla, Michelle Sia, Maria Ruth B. Pineda-Cortel, Emilyn U. Alejandro
Publikováno v: JCI Insight, Vol 6, Iss 13 (2021)
Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health
Externí odkaz: https://doaj.org/article/2188b8bb4a594bf4ac7526c1cf4a3c92
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5
Genetic Ablation of the Nutrient Sensor Ogt in Endocrine Progenitors Is Dispensable for β-Cell Development but Essential for Maintenance of β-Cell Mass
Autor: Emilyn Alejandro, Brian Akhaphong, Daniel Baumann, Alicia Wong
Publikováno v: Biomedicines; Volume 11; Issue 1; Pages: 105
Previously we utilized a murine model to demonstrate that Ogt deletion in pancreatic progenitors (OgtKOPanc) causes pancreatic hypoplasia, partly mediated by a reduction in the Pdx1-expressing pancreatic progenitor pool. Here, we continue to explore
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a953a2fbc1ea6fc483ae70fbb16169
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6
Critical Role for Macrophages in the Developmental Programming of Pancreatic β-cell Area in Offspring of Gestational Hypertension
Autor: Jean F. Regal, Emilyn U. Alejandro, Ronald R. Regal, Connor F. Laule, Margaretta E. Huchthausen, Alexa M. Molin, Melissa A. Cedars, Brian Akhaphong, Kate M. Root
Preeclampsia is a pregnancy-specific complication with long-term negative outcomes for offspring including increased susceptibility to type 2 diabetes (T2D) in adulthood. In rat Reduced Uteroplacental Perfusion Pressure (RUPP) model of chronic placen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3238ed3ca746b1d4a7a81813d483c6ef
https://doi.org/10.2337/figshare.20995165.v1
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7
Abstract P349: Decreased Complement Component C3 In Islets Is Associated With A Reduction In Pancreatic Beta Cell Area In Rat Offspring Following Chronic Placental Ischemia-induced Hypertension
Autor: Jean F Regal, Melissa A Cedars, Kate M Root, Margaretta E Huchthausen, Brian Akhaphong, Emilyn U Alejandro
Publikováno v: Hypertension. 79
Gestational hypertension with or without low birth weight is associated with increased risk for Type 2 diabetes in offspring. Pancreatic beta cell mass is set very early in life and can influence whether an individual develops Type 2 diabetes. We pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27a95d968a8e39c2d35c39217b5faccc
https://doi.org/10.1161/hyp.79.suppl_1.p349
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8
1445-P: Ogt Is Dispensable for Beta-Cell Development but Essential for Postnatal Beta-Cell Identity Maintenance via Pdx1
Autor: ALICIA L. WONG, BRIAN AKHAPHONG, AMBER D. LOCKRIDGE, EMILYN ALEJANDRO
Publikováno v: Diabetes. 71
T2D is associated with reduced pancreatic β-cell mass, in part, by increased apoptosis and identity loss as insulin-producing cells. Nutrient-sensor protein O-GlcNAc Transferase (Ogt) is a regulator of pancreas development and β-cell function. We h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40094764627b4715de0509f8567548e
https://doi.org/10.2337/db22-1445-p
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10
Critical Role for Macrophages in the Developmental Programming of Pancreatic β-Cell Area in Offspring of Hypertensive Pregnancies
Autor: Kate M. Root, Brian Akhaphong, Melissa A. Cedars, Alexa M. Molin, Margaretta E. Huchthausen, Connor F. Laule, Ronald R. Regal, Emilyn U. Alejandro, Jean F. Regal
Publikováno v: Diabetes. 71(12)
Preeclampsia is a pregnancy-specific complication with long-term negative outcomes for offspring, including increased susceptibility to type 2 diabetes (T2D) in adulthood. In a rat reduced uteroplacental perfusion pressure (RUPP) model of chronic pla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd94a4eefebab7165ffec037cb6ae3ba
https://pubmed.ncbi.nlm.nih.gov/36125850
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