Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Brian Aizenstein"'
Autor:
Matt Neville, Rebecca Selzer, Brian Aizenstein, Megan Maguire, Kirk Hogan, Robert Walton, Ken Welsh, Bruce Neri, Monika de Arruda
Publikováno v:
BioTechniques, Vol 32, Iss 6S, Pp S34-S43 (2002)
The cytochrome p450 (CYP) superfamily comprises enzymes that play an essential role in the transformation of medically relevant compounds. Accurate genotyping of polymorphisms in members of this family is drawing increasing interest because certain a
Externí odkaz:
https://doaj.org/article/a4f893d1301441879c98866fed1c4810
Autor:
Brian Aizenstein, Eric J. Kunkel, Kevan M. Shokat, Benjamin T. Houseman, Zachary A. Knight, Olusegun Williams, Randy Hoffman
Publikováno v:
Chemistry & Biology. 17:123-134
PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking the antipr
Autor:
Bruce Neri, Kirk J. Hogan, Ken I. Welsh, Rebecca R. Selzer, Matt J. Neville, Monika de Arruda, Megan Maguire, Brian Aizenstein, Robert Walton
Publikováno v:
BioTechniques. 32:S34-S43
The cytochrome p450 (CYP) superfamily comprises enzymes that play an essential role in the transformation of medically relevant compounds. Accurate genotyping of polymorphisms in members of this family is drawing increasing interest because certain a
Autor:
Maria Giakoumopoulos, Douglas W. Mahoney, Ashley M. Poenitzsch Strong, Brian Aizenstein, Graham P. Lidgard, Drew Eckmayer, David E. Midthun, Carla Volkmann, Melissa M. Gray, Hatim T. Allawi, Tracy C. Yab, William R. Taylor, Evan Flietner, Tamara Sander, Barry M. Berger, David A. Ahlquist, John B. Kisiel, Austin Oliphant
Publikováno v:
Cancer Research. 77:712-712
Purpose: Lung cancer is the leading cause of cancer deaths worldwide. Most present symptomatically at late stage with high lethality. Early detection reduces mortality but accurate and readily accessible tools for population screening are limited. By
Autor:
Carla Volkmann, Austin Oliphant, Hatim T. Allawi, Jennifer H. Carlson, Douglas W. Mahoney, Thomas C. Smyrk, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Evan Flietner, Graham P. Lidgard, John B. Kisiel, Drew Eckmayer, Barry M. Berger, Abram Michael Vaccaro, Brian Aizenstein, Eric S. Edell, Vipul Rathore, Tracy C. Yab, Tamara Sander
Publikováno v:
Journal of Clinical Oncology. 34:8527-8527
8527Background: Lung cancer remains the #1 cancer killer in the US, and effective screening approaches are desperately needed. Lung cancer alone accounts for 221,000 deaths annually. DNA methylatio...
Autor:
Tatsuya Okuzumi, Randy Hoffman, Brian Aizenstein, Kevan M. Shokat, Chao Zhang, Daniel C. Gray, Dorothea Fiedler
Publikováno v:
Nature chemical biology
Nature chemical biology, vol 5, iss 7
Nature chemical biology, vol 5, iss 7
The kinase Akt plays a central role as a regulator of multiple growth factor input signals, thus making it an attractive anticancer drug target. A-443654 is an ATP-competitive Akt inhibitor. Unexpectedly, treatment of cells with A-443654 causes parad
Autor:
Beatriz González, Brian Aizenstein, Beth Apsel, Tamim Nazif, Zachary A. Knight, Kevan M. Shokat, Roger L. Williams, Jimmy A. Blair, Randy Hoffman, Morri E. Feldman
Publikováno v:
Nature chemical biology, vol 4, iss 11
Nature chemical biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature chemical biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
9 pags, 8 figs
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0ef5248433e131f85c17ef581c3b96
https://escholarship.org/uc/item/70c0785z
https://escholarship.org/uc/item/70c0785z
Autor:
Tatsuya Okuzumi, Kevan M. Shokat, Randy Hoffman, Brian Aizenstein, Gregory S. Ducker, Chao Zhang
Publikováno v:
Molecular BioSystems. 6:1389
The kinase Akt is a key signaling node in regulating cellular growth and survival. It is implicated in cancer by mutation and its role in the downstream transmission of aberrant PI3K signaling. For these reasons, Akt has become an increasingly import