Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brian A.M. Rudd"'
Autor:
Ines U Böhm, Brian A.M. Rudd, Peter F. Leadlay, Steven Boakes, Markiyan Oliynyk, J. Staunton, Jesus Cortes, W P Revill
Publikováno v:
Microbial Physiology. 8:73-80
A previously unidentified set of genes encoding a modular polyketide synthase (PKS) has been sequenced in Saccharopolyspora erythraea, producer of the antibiotic erythromycin. This new PKS gene cluster (pke) contains four adjacent large open reading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46a2af8b42db492ecf3f499a2115e39
https://doi.org/10.1159/000084562
https://doi.org/10.1159/000084562
Autor:
Peter F. Leadlay, J. Staunton, Hrvoje Petković, Steven G. Kendrew, Brian A.M. Rudd, Lindsey Low, Rachel E. Lill, Jesus Cortes, Francesca Del Vecchio, Barrie Wilkinson
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 30:489-494
Sequence comparisons of multiple acyltransferase (AT) domains from modular polyketide synthases (PKSs) have highlighted a correlation between a short sequence motif and the nature of the extender unit selected. When this motif was specifically altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ed0bc787c420862b87659cbb528633
https://doi.org/10.1007/s10295-003-0062-0
https://doi.org/10.1007/s10295-003-0062-0
Autor:
Graham Foster, Javier Velasco, Brian A.M. Rudd, Jesus Cortes, Andrew P. Blackaby, Barrie Wilkinson
Publikováno v:
Molecular Microbiology. 44:1213-1224
The soluble, diffusible red-brown pigment produced by a Saccharopolyspora erythraea "red variant" has been shown to contain glycosylated and polymerized derivatives of 2,5,7-trihydroxy-1,4-naphthoquinone (flaviolin). Flaviolin is a spontaneous oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3826cd720cc8d17e1c9788a7fabd48b0
https://doi.org/10.1046/j.1365-2958.2002.02975.x
https://doi.org/10.1046/j.1365-2958.2002.02975.x
Autor:
Peter F. Leadlay, Dominic J.A Kearney, James A Reather, James Staunton, Brian A.M. Rudd, Iain P Thomas, Inès E. Holzbaur, Anand Ranganathan
Publikováno v:
Chemistry & Biology. 8(4):329-340
Background: Polyketides are structurally diverse natural products with a range of medically useful activities. Non-aromatic bacterial polyketides are synthesised on modular polyketide synthase multienzymes (PKSs) in which each cycle of chain extensio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d92e014c0efca0815563466630e2b79
Autor:
Philip J. Sidebottom, Catharina B.L. Abel, David Noble, John C. Lindon, Brian A.M. Rudd, Jeremy K. Nicholson
Publikováno v:
Analytical Biochemistry. 270:220-230
A novel NMR spectroscopic approach to the direct biochemical characterization of bacterial culture broths is presented. A variety of one- and two-dimensional 1 H NMR spectroscopic methods were used to characterize low-molecular-weight organic compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ced1c6cfd863b80286bcd7a5c367f0
https://doi.org/10.1006/abio.1999.4093
https://doi.org/10.1006/abio.1999.4093
Publikováno v:
FEMS Microbiology Letters. 140:15-22
A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor L-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7889ba778142992661b8694b395f0a6f
https://doi.org/10.1111/j.1574-6968.1996.tb08308.x
https://doi.org/10.1111/j.1574-6968.1996.tb08308.x
Autor:
Andrew Thorpe, W.Michael Blows, Michael J. Dawson, Brian A.M. Rudd, Nicholas J. Turner, Antony D. Buss, David Noble, Stanley M. Roberts, Wilfred F. Wall, Phillip J. Sidebottom
Publikováno v:
Tetrahedron Letters. 34:4083-4086
The novel tetrol 5 has been isolated from cultures of Strepromyces citricolor and shown to have the absolute configuration 1 S ,2 S ,3 R . Addition of 5 to an aris teromycin non-producing mutant of S. citricolor supported production of both aristerom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f2fbbddd6dbdc57d2d3e520b430288b
https://doi.org/10.1016/s0040-4039(00)60621-4
https://doi.org/10.1016/s0040-4039(00)60621-4
Publikováno v:
Molecular microbiology. 72(5)
Summary The biosynthetic pathway of the type B lantibiotic actagardine (formerly gardimycin), produced by Actinoplanes garbadinensis ATCC31049, has been cloned, sequenced and annotated. The gene cluster contains the gene garA that encodes the actagar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca1d16f4f785eb570cab399282d8386
https://pubmed.ncbi.nlm.nih.gov/19400806
https://pubmed.ncbi.nlm.nih.gov/19400806
Autor:
Brian A.M. Rudd, Shaila Choi, Antony N. Appleyard, Ann Lightfoot, Ian Chopra, Gabriele Bierbaum, Steven Boakes, Daniel M. Read, Anja Hoffmann, Jesus Cortes, Michael J. Dawson
Publikováno v:
Chemistry & Biology
Summary Mersacidin is a tetracyclic lantibiotic with antibacterial activity against Gram-positive pathogens. To probe the specificity of the biosynthetic pathway of mersacidin and obtain analogs with improved antibacterial activity, an efficient syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dffe447ae3ae51aab30d1a4d4f00a47
https://pubmed.ncbi.nlm.nih.gov/19477413
https://pubmed.ncbi.nlm.nih.gov/19477413
Publikováno v:
Applied and environmental microbiology. 72(11)
The lantibiotic (lanthionine-containing antibiotic) mersacidin is an antimicrobial peptide consisting of 20 amino acids and is produced by Bacillus sp. strain HIL Y-85,54728. The structural gene ( mrsA ) and the genes for producer self-protection, mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8290a6987cb7c1416c5e8b3d38fe0d
https://pubmed.ncbi.nlm.nih.gov/16980420
https://pubmed.ncbi.nlm.nih.gov/16980420