Zobrazeno 1 - 10
of 1 031
pro vyhledávání: '"Brian A. Walker"'
Autor:
Travis S. Johnson, Parvathi Sudha, Enze Liu, Nathan Becker, Sylvia Robertson, Patrick Blaney, Gareth Morgan, Vivek S. Chopra, Cedric Dos Santos, Michael Nixon, Kun Huang, Attaya Suvannasankha, Mohammad Abu Zaid, Rafat Abonour, Brian A. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple Myeloma is an incurable plasma cell malignancy with a poor survival rate that is usually treated with immunomodulatory drugs (iMiDs) and proteosome inhibitors (PIs). The malignant plasma cells quickly become resistant to these agent
Externí odkaz:
https://doaj.org/article/ffcdb5a5e6fa4b48a7e4c40b4a3019b8
Autor:
Enze Liu, Parvathi Sudha, Nathan Becker, Oumaima Jaouadi, Attaya Suvannasankha, Kelvin Lee, Rafat Abonour, Mohammad Abu Zaid, Brian A. Walker
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Biallelic TP53 inactivation is the most important high-risk factor associated with poor survival in multiple myeloma. Classical biallelic TP53 inactivation has been defined as simultaneous mutation and copy number loss in most studies; howev
Externí odkaz:
https://doaj.org/article/6afd26a3ada94563a39c3551369378f7
Corrigendum: Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma
Autor:
Hong Phuong Nguyen, Anh Quynh Le, Enze Liu, Annamaria Cesarano, Francesco DiMeo, Fabiana Perna, Reuben Kapur, Brian A. Walker, Ngoc Tung Tran
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ba67b86054da46258eada6bd445a2061
Autor:
Hong Phuong Nguyen, Anh Quynh Le, Enze Liu, Annamaria Cesarano, Francesco DiMeo, Fabiana Perna, Reuben Kapur, Brian A. Walker, Ngoc Tung Tran
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Multiple myeloma (MM) is a devastating plasma cell malignancy characterized by the expansion of aberrant monoclonal plasma cells in the bone marrow, leading to severe clinical manifestations and poor prognosis, particularly in relapsed/refractory cas
Externí odkaz:
https://doaj.org/article/b9200917b99549e9a2974c8b73d1ad82
Autor:
Enze Liu, Nathan Becker, Parvathi Sudha, Chuanpeng Dong, Yunlong Liu, Jonathan Keats, Gareth Morgan, Brian A. Walker
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically analyzed in multiple myeloma or its subtypes. Alternative splicing profiles for 598 newly diag
Externí odkaz:
https://doaj.org/article/f6b6857377ab487497f4b9446035a3c9
Autor:
Leo Rasche, Carolina Schinke, Francesco Maura, Michael A. Bauer, Cody Ashby, Shayu Deshpande, Alexandra M. Poos, Maurizio Zangari, Sharmilan Thanendrarajan, Faith E. Davies, Brian A. Walker, Bart Barlogie, Ola Landgren, Gareth J. Morgan, Frits van Rhee, Niels Weinhold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Spatially and temporally resolved data can improve our understanding of evolution and treatment resistance in multiple myeloma (MM). Here, the authors analyse spatial and longitudinal heterogeneity in MM patients using multi-region sequencing, and id
Externí odkaz:
https://doaj.org/article/832c8c194632414993cfa4d014438ce1
Autor:
Mark Bustoros, Shankara Anand, Romanos Sklavenitis-Pistofidis, Robert Redd, Eileen M. Boyle, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl Jannes Neuse, Mahshid Rahmat, Ankit Dutta, Tineke Casneuf, Raluca Verona, Efstathis Kastritis, Lorenzo Trippa, Chip Stewart, Brian A. Walker, Faith E. Davies, Meletios-Athanasios Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using an unsupervised binary matrix factorization clustering approach results in the iden
Externí odkaz:
https://doaj.org/article/078805a3b909435fb477a229095a08ed
Autor:
Cody Ashby, Eileen M. Boyle, Michael A. Bauer, Aneta Mikulasova, Christopher P. Wardell, Louis Williams, Ariel Siegel, Patrick Blaney, Marc Braunstein, David Kaminetsky, Jonathan Keats, Francesco Maura, Ola Landgren, Brian A. Walker, Faith E. Davies, Gareth J. Morgan
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 5, Pp 1-9 (2022)
Abstract Deciphering genomic architecture is key to identifying novel disease drivers and understanding the mechanisms underlying myeloma initiation and progression. In this work, using the CoMMpass dataset, we show that structural variants (SV) occu
Externí odkaz:
https://doaj.org/article/bfe0c5a7378449fc9275731e9baa6d54
Autor:
Faith E. Davies, Brian A. Walker
Publikováno v:
Hemato, Vol 3, Iss 2, Pp 287-297 (2022)
Although treatment of multiple myeloma has changed dramatically over time, there is still a subpopulation of patients who do not respond to treatments and are labeled as high risk. A combination of serum and genomic markers can be used to identify an
Externí odkaz:
https://doaj.org/article/e633342e1478474d9ba62012865ed6f3
Autor:
Travis S. Johnson, Christina Y. Yu, Zhi Huang, Siwen Xu, Tongxin Wang, Chuanpeng Dong, Wei Shao, Mohammad Abu Zaid, Xiaoqing Huang, Yijie Wang, Christopher Bartlett, Yan Zhang, Brian A. Walker, Yunlong Liu, Kun Huang, Jie Zhang
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-23 (2022)
Abstract We propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information “impressions,” which allow individual
Externí odkaz:
https://doaj.org/article/a416f2c8e20d4df68f061235c38432e6