Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Brian A. Roelofs"'
Publikováno v:
AAPS Open, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Structured product quality data offer tremendous promise to revolutionize the submission of drug applications. However, the quality attributes for biological products do not have a systematic naming taxonomy, and consequently this limit pose
Externí odkaz:
https://doaj.org/article/72e2a975380d40729bd55916752a1c53
Autor:
Brian A. Roelofs, Alan I. Faden, Taryn G. Aubrecht, Ethan P. Glaser, Bogdan A. Stoica, Oleg Makarevich, Brian M. Polster, Boris Sabirzhanov
Publikováno v:
Cell Death and Disease, Vol 9, Iss 11, Pp 1-19 (2018)
Cell Death & Disease
Cell Death & Disease
Traumatic brain injury (TBI) activates multiple neuronal cell death mechanisms, leading to post-traumatic neuronal loss and neurological deficits. TBI-induced cell cycle activation (CCA) in post-mitotic neurons causes regulated cell death involving c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66728eb70a9dde22d2843ba838fc576e
http://link.springer.com/article/10.1038/s41419-018-1156-y
http://link.springer.com/article/10.1038/s41419-018-1156-y
Autor:
Brian A. Roelofs, T. Chase Francis, Sruti Uppuluri, Mariusz Karbowski, Kie Itoh, Brian M. Polster, Ahmed Khalil, Andrew J. Saladino, Nolan W. Kennedy, Pascaline Clerc, Hiromi Sesaki, Laszlo Tretter, R. Blake Hill, Vera Adam-Vizi, Alexandrea M. Miller, Edward Cherok, Lora K. Picton, Shealinna X. Ge, Tanya Kumar, Evan A. Bordt, Nagendra Yadava
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afd387d613c5543232d146dfcbe8b65
https://europepmc.org/articles/PMC5398851/
https://europepmc.org/articles/PMC5398851/
Autor:
J Waddell, Brian A. Roelofs, Hyehyun Hwang, Brian M. Polster, Shealinna X. Ge, Pascaline Clerc, Hiromi Sesaki, Mariusz Karbowski
Publikováno v:
British Journal of Pharmacology. 171:1988-1999
Background and Purpose Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and is thought to promote Bax/Bak-induced cytochrome c release during apoptosis. Conformationally active Bax, Bak and Bax/Bak-activating BH3-only proteins, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bac8e93ea6e900cd6547adf6414ebe92
https://doi.org/10.1111/bph.12515
https://doi.org/10.1111/bph.12515
Autor:
Liron Boyman, Mariusz Karbowski, Sunan Li, W. Jonathan Lederer, Hiromi Sesaki, Shan Xu, Brian A. Roelofs
Publikováno v:
The Journal of Cell Biology
Dynamic assembly and disassembly of F-actin on mitochondria participate in Drp1-mediated mitochondrial fission.
In addition to established membrane remodeling roles in various cellular locations, actin has recently emerged as a participant in mi
In addition to established membrane remodeling roles in various cellular locations, actin has recently emerged as a participant in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b5f36509d0be0e50e3994b8a275ca
https://pubmed.ncbi.nlm.nih.gov/25547155
https://pubmed.ncbi.nlm.nih.gov/25547155
Publikováno v:
Methods in enzymology. 547
Technological improvements in microscopy and the development of mitochondria-specific imaging molecular tools have illuminated the dynamic rearrangements of these essential organelles. These rearrangements are mainly the result of two opposing proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640cf94790310b0e2fd2fc933e1d9dd6
https://pubmed.ncbi.nlm.nih.gov/25416352
https://pubmed.ncbi.nlm.nih.gov/25416352
Mitochondrial reactive oxygen species (ROS) are implicated in signal transduction, inflammation, neurodegenerative disorders, and normal aging. Net ROS release by isolated brain mitochondria derived from a mixture of neurons and glia is readily quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c65ce10d32a2088e7b62527ce520562
https://europepmc.org/articles/PMC4484872/
https://europepmc.org/articles/PMC4484872/
Publikováno v:
Mitochondrion. 13(2)
Anti- and pro-apoptotic Bcl-2 family members regulate the mitochondrial phase of apoptotic cell death. The mitochondrial targeting mechanisms of Bcl-2 family proteins are tightly regulated. Known outer mitochondrial membrane targeting sequences inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22839d0ef06a1c072dc53f385ddb826
https://pubmed.ncbi.nlm.nih.gov/23333404
https://pubmed.ncbi.nlm.nih.gov/23333404
Autor:
Dimitry Ofengeim, Takahiro Miyawaki, Elizabeth A. Jonas, John A. Hickman, Fabrizio Pontarelli, Richard J. Flannery, Kambiz N. Alavian, Hongmei Li, Silvio Sacchetti, Brian A. Roelofs, R. Suzanne Zukin, J. Marie Hardwick, Ying Bei Chen
Publikováno v:
Nature neuroscience
Transient global ischemia in rats induces delayed death of hippocampal CA1 neurons. Early events include caspase activation, cleavage of anti-death Bcl-2 family proteins and large mitochondrial channel activity. However, whether these events have a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c68108d788d81184b6552b3ca8ed5f3
https://pubmed.ncbi.nlm.nih.gov/22449958
https://pubmed.ncbi.nlm.nih.gov/22449958
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d75601ea5963d555f00117d09cf84160
https://doi.org/10.1096/fasebj.24.1_supplement.518.1
https://doi.org/10.1096/fasebj.24.1_supplement.518.1