Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brian A. Provencher"'
Publikováno v:
Journal of Chemical Education. 97:1303-1309
Educators are constantly looking to improve their pedagogical strategies. This can range from teaching strategies for a specific topic to holistic curriculum changes. Recently, the approach that ch...
Autor:
Jimmy Franco, Brian A. Provencher
Publikováno v:
Journal of Chemical Education. 96:586-592
In recent years, researchers have worked diligently to identify more effective means of facilitating student learning. Some promising pedagogical techniques that have emerged include the flipped-class model and test-enhanced learning. These pedagogic
Publikováno v:
Journal of Chemical Education
During the Spring 2020 semester, many institutions abruptly transitioned their courses from face-to-face instruction to remote learning in response to the COVID-19 pandemic. To address the unique challenges posed by the remote teaching and learning m
Autor:
Brian A. Provencher, Aaron Janowsky, Jared K. Nelson, Jianhua Tian, Amy J. Eshleman, Mario D. Gonzalez, Peter C. Meltzer, Robert A. Johnson, Olga Kryatova, Xiao Shi
Publikováno v:
Journal of medicinal chemistry. 61(20)
Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increa
Autor:
Shayla Russell, Anna W. Sromek, Elena H. Chartoff, Jean M. Bidlack, John L. Neumeyer, Brian I. Knapp, Brian A. Provencher
Publikováno v:
ACS Chemical Neuroscience. 5:93-99
A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-D-aspartate (NMDA) channel, and sigma 1 and 2 receptors. It was found that levo isomers te
Autor:
Wei Li, Shayla Russell, Elena H. Chartoff, John L. Neumeyer, Brian I. Knapp, Anna W. Sromek, Jean M. Bidlack, Brian A. Provencher
Publikováno v:
Journal of Medicinal Chemistry. 56:8872-8878
Previous studies with aminothiazolomorphinans suggested that this class of opioid ligands may be useful as a potential pharmacotherapeutic to decrease drug abuse. Novel aminothiazole derivatives of cyclorphan were prepared to evaluate a series of ami
Publikováno v:
Angewandte Chemie. 123:10753-10757
Publikováno v:
Angewandte Chemie International Edition. 50:10565-10569
New phase transfer catalysts are reported for the first example of an organocatalytic asymmetric conjugate addition of cyanide with acetone cyanohydrin. Utilizing an accessible cupreidinium salt and a cyanation reagent suitable for industrial scale,
Publikováno v:
ChemInform. 42
The new PTC is used to catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones with aldehydes to give optically active epoxides.
Autor:
Brian A. Provencher, Walter W. Massefski, John C. McKew, Gregory M. Ciszewski, Arthur Lee, Stephen D. Huhn, Derek Cecil Cole, Lori Krim Gavrin
Publikováno v:
The Journal of organic chemistry. 72(3)
This work describes two distinct routes to prepare pyrazolo[1,5-alpha]pyrimidin-7-ones and two distinct routes to prepare pyrazolo[1,5-alpha]pyrimidin-5-ones. Use of 1,3-dimethyluracil as the electrophile in the preparation of the pyrimidin-5-one reg