Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Brian A. Johns"'
Autor:
Brian A. Johns, Christin A. Hamilton, Allison J. Armstrong, Robert A. Figler, Maria Sol Collado, Taylor D. Pourtaheri, Brad R. Henke, Marshall M. Summar, Stephen A. Hoang, Kimberly A. Chapman, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson
Publikováno v:
Mol Genet Metab
Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine and odd-chain fatty acids. These are multi-organ disorders caused by the enzymatic deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d2bba59a2136c64aeca4cb4d67b68
https://doi.org/10.1016/j.ymgme.2021.03.001
https://doi.org/10.1016/j.ymgme.2021.03.001
Publikováno v:
Clinical Pharmacology in Drug Development. 9:972-977
GSK2838232 is a novel, potent HIV-1 maturation inhibitor for use in regimen-based combination antiretroviral therapy from a once-daily oral dose boosted with a pharmacoenhancer (ritonavir or cobicistat). This phase 1 study in healthy participants was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd92487194df339d90e1e6ca694650b2
https://doi.org/10.1002/cpdd.820
https://doi.org/10.1002/cpdd.820
Autor:
John E Dillberger, Thomas D Roper, Allison J. Armstrong, Brian R. Wamhoff, Stephen A. Hoang, Matthew W. Olson, Justin M. Taylor, Brad R. Henke, John E. Reardon, Maria Sol Collado, Brian A. Johns, Robert A. Figler, Taylor D. Pourtaheri
Publikováno v:
Journal of medicinal chemistry. 64(8)
Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in the enzymes P-CoA carboxylase and methylmalonyl-CoA (M-CoA) mutase, respectively. PA and MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254da545beecc6f429bfbe4bad4afc4f
https://pubmed.ncbi.nlm.nih.gov/33848153
https://pubmed.ncbi.nlm.nih.gov/33848153
Autor:
Jianfeng Xu, Anita Scribner, Brian A. Johns, Mark Johnson, Jerry Jeffrey, Viviana Wilches, Moti Ramgopal, Edwin DeJesus, Franco Felizarta, Christine L. Talarico, Jianjun Gan, Paul M. Benson, Roxanne C. Jewell, Etienne Dumont, Fiona Halliday, Sara Duckworth Harward
Publikováno v:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 71(5)
Background GSK2838232 is a second-generation, potent, small-molecule, oral human immunodeficiency virus type 1 (HIV-1) maturation inhibitor for once-daily administration boosted with a pharmacoenhancer. Methods The phase 2a, proof-of-concept study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379ba8f6e89f8981a98d23226af0f9ce
https://pubmed.ncbi.nlm.nih.gov/31769793
https://pubmed.ncbi.nlm.nih.gov/31769793
Publikováno v:
European Journal of Medicinal Chemistry. 117:99-112
A novel series of HIV-1 integrase strand transfer inhibitors were designed using the venerable two-metal binding pharmacophore model and incorporating structural elements from two different literature scaffolds. This manuscript describes a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06644c82bc4476e5604c544b81e2660
https://doi.org/10.1016/j.ejmech.2016.03.038
https://doi.org/10.1016/j.ejmech.2016.03.038
Autor:
Sandra J. Baldwin, Jianfeng Xu, Matt Davies, Jerry Jeffrey, Matthew Burke, Allan R Tenorio, Brian A. Johns, Elizabeth Gould, Amanda Peppercorn, Roxanne C. Jewell, Mark Johnson, Yu Lou
Publikováno v:
Pharmacology researchperspectives. 6(4)
This work aimed to assess the safety, tolerability, pharmacokinetics (PK), and relative bioavailability of GSK2838232, an investigational HIV maturation inhibitor. GSK2838232 was administered over four dose-escalation studies in healthy subjects whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4413391e38d9e7f99b7279ba5b19681d
https://pubmed.ncbi.nlm.nih.gov/29930812
https://pubmed.ncbi.nlm.nih.gov/29930812
The Validity and Reliability of a Hybrid Reality Simulator for Wire Navigation in Orthopedic Surgery
Publikováno v:
IEEE Transactions on Human-Machine Systems. 45:119-125
Creating training simulators for orthopedic surgery presents unique and largely unexplored engineering challenges. One of these challenges is simulating both the large forces and subtle haptic feedback involved in drilling into bone. This paper invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d72f4934b1c02e012b2c8e43d1afcc
https://doi.org/10.1109/thms.2014.2339324
https://doi.org/10.1109/thms.2014.2339324
Autor:
Jun Tang, Kevin W. Brown, Jerry Jeffrey, Charlene B. McDanal, Brian A. Johns, Sonia R. Miranda, Stacey A. Jones, David M. Irlbeck, Cristin M. Galardi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
A new class of betulin-derived α-keto amides was identified as HIV-1 maturation inhibitors. Through lead optimization, GSK8999 was identified with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively. When
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218669177b08ef6a1fe9d91139f48e57
https://pubmed.ncbi.nlm.nih.gov/28454672
https://pubmed.ncbi.nlm.nih.gov/28454672