Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brian A. Harsch"'
Autor:
Rachel E. Walker, Chesney K. Richter, Ann C. Skulas-Ray, Michael R. Flock, Brian A. Harsch, Carmen E. Annevelink, Penny M. Kris-Etherton, Gordon L. Jensen, Gregory C. Shearer
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100353- (2023)
Oxylipins are produced enzymatically from polyunsaturated fatty acids, are abundant in triglyceride-rich lipoproteins (TGRLs), and mediate inflammatory processes. Inflammation elevates TGRL concentrations, but it is unknown if the fatty acid and oxyl
Externí odkaz:
https://doaj.org/article/eaa7abe666b144b7ae36cd2c79618922
Autor:
Timothy D. O’Connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer
Publikováno v:
Physiology (Bethesda, Md.). 37(6)
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f85a05aeb80d266031c5a4bf7482c4
https://pubmed.ncbi.nlm.nih.gov/35944007
https://pubmed.ncbi.nlm.nih.gov/35944007
Autor:
Gregory C. Shearer, Rachel E Walker, Brandon M. Wagner, Katherine A. Murphy, Wei Huang, Casey D. Wright, Quinn S. Wells, Brian A. Harsch, Chastity L Healy, Katherine M Ernste, Robert C. Block, Sonal S. Joshi, Timothy D. O'connell, Shue Huang, Brian C. Jensen, Nathan L. Tintle
Publikováno v:
Cardiovasc Res
Aims Free fatty acid receptor 4 (Ffar4) is a G-protein-coupled receptor for endogenous medium-/long-chain fatty acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in the heart is unclear. Given its putative benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c30555acf8beb67e81b310e6f6fa31
https://doi.org/10.1093/cvr/cvab111
https://doi.org/10.1093/cvr/cvab111
Autor:
Robert C. Block, Timothy D. O'Connell, Gregory C. Shearer, Brian C. Jensen, Katherine A. Murphy, Casey D. Wright, Rachel E Walker, Brandon M. Wagner, Brian A. Harsch, Nathan L. Tintle, Shue Huang, Wei Huang, Chastity L Healy, Sonal S. Joshi, Katherine M Ernste
BackgroundNon-resolving activation of immune responses is central to the pathogenesis of heart failure (HF). Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor (GPR) for medium-and long-chain fatty acids (FA) that regulates metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd54dcb74161cd2c9959bc4b9b54b811
https://doi.org/10.1101/776294
https://doi.org/10.1101/776294
Autor:
Gregory C. Shearer, Chastity L Healy, Katherine A. Murphy, Brandon M. Wagner, Wei Huang, Katherine M Ernste, Timothy D. O'Connell, Brian A. Harsch, Brian C. Jensen, Sonal S. Joshi
Publikováno v:
Circulation Research. 125
Free fatty acid receptor 4 (Ffar4, GPR120) is a GPCR for long chain fatty acids, including omega-3 polyunsaturated fatty acids (ω3-PUFAs). Previously, we demonstrated that eicosapentaenoic acid (EPA), an ω3-PUFA, prevents interstitial fibrosis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc9e587295f838d461098559c9b6abb
https://doi.org/10.1161/res.125.suppl_1.255
https://doi.org/10.1161/res.125.suppl_1.255
Autor:
Brian A. Harsch, Gregory C. Shearer, Chastity L Healy, Timothy D. O'Connell, Erika F. Dahl, Steven C. Wu
G protein–coupled receptors that signal through Gα(q) (G(q) receptors), such as α(1)-adrenergic receptors (α(1)-ARs) or angiotensin receptors, share a common proximal signaling pathway that activates phospholipase Cβ1 (PLCβ1), which cleaves ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f0999378519bf66ba7140ebad37bf7
https://europepmc.org/articles/PMC5995527/
https://europepmc.org/articles/PMC5995527/