Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Brian A. Chauder"'
Publikováno v:
Journal of Medicinal Chemistry
Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb060c63abcd36d4c565f030c85a766
https://doi.org/10.1021/jm501035j
https://doi.org/10.1021/jm501035j
Autor:
Taekyu Lee, Stephen W. Fesik, Pedro M. Garcia-Barrantes, Edward T. Olejniczak, Jason P. Burke, Bin Zhao, Brian A. Chauder, Anders Friberg, R. Nathan Daniels, Dominico Vigil, DeMarco V. Camper
Publikováno v:
Journal of Medicinal Chemistry. 56:15-30
Myeloid cell leukemia 1 (Mcl-1), a member of the Bcl-2 family of proteins, is overexpressed and amplified in various cancers and promotes the aberrant survival of tumor cells that otherwise would undergo apoptosis. Here we describe the discovery of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a5af2f525a4290db68505dbbfe89f6
https://doi.org/10.1021/jm301448p
https://doi.org/10.1021/jm301448p
Autor:
Colleen M. Niswender, Kyle A. Emmitte, Karen J. Gregory, Andrew S. Felts, Danny G. Winder, Jens Meiler, Christopher M. Olsen, Alice L. Rodriguez, Jeffrey P. Lamb, Craig W. Lindsley, Usha N. Menon, Ralf Mueller, Brittney S. Bates, Eric S. Dawson, Carrie K. Jones, P. Jeffrey Conn, Alexander S. Kane, Brian A. Chauder, Sataywan B. Jadhav
Publikováno v:
ChemMedChem. 7:406-414
Glutamate, the major excitatory neurotransmitter, functions in the brain via activation of ligand gated cation channels and also the eight subtypes of Class C G protein-coupled metabotropic glutamate receptors (mGlus).[1] Selective allosteric modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f05778db6ec355ffe22f60073c5ab46b
https://doi.org/10.1002/cmdc.201100510
https://doi.org/10.1002/cmdc.201100510
Publikováno v:
Future Medicinal Chemistry. 2:757-774
Inward rectifier potassium (Kir) channels have been postulated as therapeutic targets for several common disorders including hypertension, cardiac arrhythmias and pain. With few exceptions, however, the small-molecule pharmacology of this family is l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fef05113996ffa96b9e3f03dad5944d
https://doi.org/10.4155/fmc.10.179
https://doi.org/10.4155/fmc.10.179
Autor:
Pat Wheelan, Brian A. Chauder, Christian Watson, Terrence Peter Kenakin, Robert M. Ferris, Cecilia S. Koble, Deborah K. Jones-Hertzog, Michael Youngman, Hanbiao Yang, Christopher J Aquino, Felix Deanda, Wieslaw M. Kazmierski
Publikováno v:
Journal of Medicinal Chemistry. 51:6538-6546
We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the (125)I-[MIP-1beta] binding and Ba-L-HOS antiviral assays resulted in the discovery of 64 and 68 in the 4,4-disubstitite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342620a21dc2e3f0195bfb53c185b26b
https://doi.org/10.1021/jm800598a
https://doi.org/10.1021/jm800598a
Autor:
James B. Thompson, Brian Andrew Chauder, Elie A. Tabet, Wieslaw M. Kazmierski, Eric E. Boros, Cecilia S. Koble, Du Kien S
Publikováno v:
Synthetic Communications. 36:279-284
A four‐step, high‐yielding, kilogram‐scale protocol to prepare aldehyde 5 is reported. The key reaction is a mild, two‐step Cu2O‐mediated decarboxylation of cyanoester 3 that proceeds in excellent yield. The general applicability of this me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3c76f6ade83c00d18efe82241347f8
https://doi.org/10.1080/00397910500374971
https://doi.org/10.1080/00397910500374971
Publikováno v:
Synthesis. 2001:0140-0144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de369eaef7a07e64b0ce0838483332ce
https://doi.org/10.1055/s-2001-9747
https://doi.org/10.1055/s-2001-9747
Publikováno v:
Pure and Applied Chemistry. 71:1521-1529
New developments from our laboratories in Directed ortho (DoM) and remote (DreM) metalation reactions are presented and connections to transition metal catalyzed cross coupling and olefin metathesis processes are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58ae45813823137acc4534ab65fa137
https://doi.org/10.1351/pac199971081521
https://doi.org/10.1351/pac199971081521
Publikováno v:
Angewandte Chemie International Edition. 38:1435-1438
The oxygen-rich heterocyclic compound 1-which was proposed to be the structure of plicadin, the alleged naturally occurring coumestan from the herb Psoralea plicata-was synthesized by the rational combinations of directed ortho and remote metalation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1557ad57641138ccb964a0cbf15652
https://doi.org/10.1002/(sici)1521-3773(19990517)38:10<1435::aid-anie1435>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19990517)38:10<1435::aid-anie1435>3.0.co
Autor:
Rosangela S. C. Lopes, Victor Snieckus, Claudio C. Lopes, Alcides J. M. da Silva, Brian A. Chauder
Publikováno v:
Synthesis. 1998:279-282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6cd33f866891328db3fb05129505eb5
https://doi.org/10.1055/s-1998-2042
https://doi.org/10.1055/s-1998-2042