Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Brian A. Boone"'
Autor:
Eileen Tabrizi, Fatemeh Pourteymour Fard Tabrizi, Gehad Mahmoud Khaled, Michael P. Sestito, Saeid Jamie, Brian A. Boone
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The gut microbiome plays a significant role in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), influencing oncogenesis, immune responses, and treatment outcomes. Studies have identified microbial species like Porphyromonas gingivalis and
Externí odkaz:
https://doaj.org/article/c071935cf6c74ab4a3fa37b8eaee3576
Autor:
Brian A. Boone, MD, FACS
Publikováno v:
Annals of Surgery Open, Vol 5, Iss 1, p e373 (2024)
Externí odkaz:
https://doaj.org/article/a2126feee2f34fc49d8d3274848c25c3
Autor:
Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Abstract Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving outcomes. Myeloid cells are of particular importance for PDAC progression; howeve
Externí odkaz:
https://doaj.org/article/cd93151d4b0d46eca1793e11880f23a2
Autor:
Emily A. Henderson, Abby Ivey, Soo Jeon Choi, Stell Santiago, Dudley McNitt, Tracy W. Liu, Slawomir Lukomski, Brian A. Boone
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated
Externí odkaz:
https://doaj.org/article/b7a358c44148488ba16c0498d2cab4a6
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 3, p 768 (2024)
Gallbladder cancer is a devastating disease with a 5-year survival of only 18%. The majority of gallbladder cancers are discovered incidentally in patients undergoing cholecystectomy. During non-oncologic laparoscopic cholecystectomy for gallbladder
Externí odkaz:
https://doaj.org/article/6d6dd19a41b34a80b1d68b90f06f7614
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Pancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resist
Externí odkaz:
https://doaj.org/article/0076cc2628404b40905f55a8759dfaa0
Publikováno v:
Clinical Case Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Key Clinical Message The robotic modified Strong procedure is a safe and effective approach for surgical management of superior mesenteric artery syndrome in properly selected patients. Abstract Superior mesenteric artery syndrome is a rare syndrome
Externí odkaz:
https://doaj.org/article/18f91ef1d01a4b90b07b5727935882fc
Autor:
Samer S. AlMasri, Mazen S. Zenati, Annissa Desilva, Ibrahim Nassour, Brian A. Boone, Aatur D. Singhi, David L. Bartlett, Lance A. Liotta, Virginia Espina, Patricia Loughran, Michael T. Lotze, Alessandro Paniccia, Herbert J. Zeh III, Amer H. Zureikat, Nathan Bahary
Publikováno v:
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Abstract Introduction Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase rese
Externí odkaz:
https://doaj.org/article/22bcc880a5264081a326a90968f1c5d6
Autor:
Naomi Fei, Sijin Wen, Rajesh Ramanathan, Melissa E. Hogg, Amer H. Zureikat, Michael T. Lotze, Nathan Bahary, Aatur D. Singhi, Herbert J. Zeh, Brian A. Boone
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1822-1829 (2021)
Abstract SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular
Externí odkaz:
https://doaj.org/article/fc1b523b0b3a44e2a592d00a88565d98
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2551 (2022)
Chloroquine (CQ) and Hydroxychloroquine (HCQ), initially utilized in the treatment of malaria, have now developed a long list of applications. Despite their clinical relevance, their mechanisms of action are not clearly defined. Major pathways by whi
Externí odkaz:
https://doaj.org/article/fe8e253e48024054ba5a9326b56a307a