Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brian A. Babbin"'
Autor:
Andrei I Ivanov, Moshe Bachar, Brian A Babbin, Robert S Adelstein, Asma Nusrat, Charles A Parkos
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e658 (2007)
The integrity and function of the epithelial barrier is dependent on the apical junctional complex (AJC) composed of tight and adherens junctions and regulated by the underlying actin filaments. A major F-actin motor, myosin II, was previously implic
Externí odkaz:
https://doaj.org/article/8bfa21258ada4fa8b2c15b2319df07c9
Autor:
Jan Michael A Klapproth, Maiko Sasaki, Brian A. Babbin, Kirsten W. Gerner-Schmidt, Asma Nusrat
Publikováno v:
The American Journal of Pathology. 174:1347-1357
Lymphocyte inhibitory factor A (lifA) in Citrobacter rodentium encodes the large toxin lymphostatin, which contains two enzymatic motifs associated with bacterial pathogenesis, a glucosyltransferase and a protease. Our aim was to determine the effect
Autor:
Asma Nusrat, Charles A. Parkos, Robert S. Adelstein, Moshe Bachar, Stefan Koch, Brian A. Babbin, Mary Anne Conti, Andrei I. Ivanov
Publikováno v:
The American Journal of Pathology. 174:436-448
Epithelial cell motility is critical for self-rejuvenation of normal intestinal mucosa, wound repair, and cancer metastasis. This process is regulated by the reorganization of the F-actin cytoskeleton, which is driven by a myosin II motor. However, t
Autor:
Christopher T. Capaldo, Stefan Koch, Mike G. Laukoetter, Roderick J. Flower, Porfirio Nava, Brian A. Babbin, Eric Peatman, Asma Nusrat, Eric Allan Severson, Winston Y. Lee, Mauro Perretti, Charles A. Parkos
Publikováno v:
The Journal of Immunology. 181:5035-5044
During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses an
Autor:
Kenneth J. Mandell, L. Matthew Winfree, Asma Nusrat, Oskar Laur, Charles A. Parkos, Andrei I. Ivanov, Brian A. Babbin
Publikováno v:
The American Journal of Pathology. 170:951-966
Epithelial cell migration is a critical event in gastrointestinal mucosal wound healing and is dependent on actin cytoskeletal reorganization. We observed increased expression of an actin regulatory protein, annexin 2, in migrating intestinal epithel
Autor:
Michael Koval, Eric Peatman, Ifor R. Williams, Porfirio Nava, Christopher T. Capaldo, Mike G. Laukoetter, Brian A. Babbin, Asma Nusrat, Jacquelyn A. Campbell, Terence S. Dermody, Charles A. Parkos, Eric Allan Severson, Winston Y. Lee
Publikováno v:
The Journal of Experimental Medicine
Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular studies are lacking. Candidate regulatory molecules localized within the tight junction (TJ) include Junctional Adhesion Molecule (JAM-A), which has been implic
Autor:
George Grant, Huixia Wu, T. P. King, Rheinallt M. Jones, Matam Vijay-Kumar, Andrew T. Gewirtz, Andrew S. Neish, Brian A. Babbin, Denise Kelly
Publikováno v:
The American Journal of Pathology. 169:1686-1700
Flagellin, the primary component of bacterial flagella, is a potent activator of toll-like receptor 5 (TLR5) signaling and is a major proinflammatory determinant of enteropathogenic Salmonella. In accordance with this, we report here that aflagellate
Autor:
Tao Wu, Winston Y. Lee, Yuan Liu, Asma Nusrat, Ingrid C. McCall, Ke Zen, Brian A. Babbin, Charles A. Parkos
Publikováno v:
Molecular Biology of the Cell. 16:2694-2703
Neutrophil (polymorphonuclear leukocytes [PMN]) transepithelial migration during inflammatory episodes involves a complex series of adhesive interactions and signaling events. Previous studies have shown that key adhesive interactions between leukocy
Publikováno v:
Journal of Biological Chemistry. 280:11665-11674
Epithelial tight junctions form a selectively permeable barrier to ions and small molecules. Junctional adhesion molecule 1 (JAM1/JAM-A/F11R) is a tight junction-associated transmembrane protein that has been shown to participate in the regulation of
Publikováno v:
Molecular Biology of the Cell. 15:3926-3937
Neutrophil (PMN) transepithelial migration is dependent on the leukocyte β2integrin CD11b/CD18, yet the identity of epithelial counterreceptors remain elusive. Recently, a JAM protein family member termed JAM-C was implicated in leukocyte adhesive i