Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Brian A Perrino"'
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134876 (2015)
Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-contracted with KCl or carbachol (CCh), and the pho
Externí odkaz:
https://doaj.org/article/e9ae67a176544eafafdd252da55bb03e
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Purinergic signaling is important for normal bladder function, as it is thought to initiate the voiding reflex and modulate smooth muscle tone. The availability of adenine nucleotides and nucleosides (aka purines) at receptor sites of various cell ty
Externí odkaz:
https://doaj.org/article/7ddc85ab543348b78751ed2057a2314f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protease-activated receptor-1 (PAR1) is highly expressed in murine colonic smooth muscles. Responses to PAR1 activation are complex and result from responses in multiple cell types. We investigated whether PAR1 responses are altered in infla
Externí odkaz:
https://doaj.org/article/4004c89198b04868adc8bee07b8f81b3
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1688 (2023)
The interplay of the enteric nervous system (ENS) and SIP syncytium (smooth muscle cells–interstitial cells of Cajal–PDGFRα+ cells) plays an important role in the regulation of gastrointestinal (GI) motility. This study aimed to investigate the
Externí odkaz:
https://doaj.org/article/bcb9d7e3e8714a56b0714789c0963ca2
Autor:
Ken Lee, Sang O Park, Pil-Cho Choi, Seung-Bum Ryoo, Haeyeong Lee, Lauren E. Peri, Tong Zhou, Robert D. Corrigan, Andrew C. Yanez, Suk B. Moon, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Volume accommodation occurs via a novel mechanism involving interstitial cells in detrusor muscles. The interstitial cells in the bladder are PDGFRα+, and they restrain the excitability of smooth muscle at low levels and prevents the develo
Externí odkaz:
https://doaj.org/article/2ffc5cafa1a74f33afd2860ded277ffe
Autor:
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva
Publikováno v:
Metabolites, Vol 13, Iss 1, p 30 (2022)
Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urin
Externí odkaz:
https://doaj.org/article/b83f19e5c3b2449d8bd49bb35ce64f74
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C992-C1006
The main function of the stomach is to digest ingested food. Gastric antrum muscular contractions mix ingested food with digestive enzymes and stomach acid and propel the chyme through the pyloric sphincter at a rate in which the small intestine can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c649ea3cd44460e53466a5201f1985d1
https://doi.org/10.1152/ajpcell.00043.2023
https://doi.org/10.1152/ajpcell.00043.2023
Autor:
Sang Don Koh, Bernard T. Drumm, Hongli Lu, Hyun Jin Kim, Seung-Bum Ryoo, Heung-Up Kim, Ji Yeon Lee, Poong-Lyul Rhee, Qianqian Wang, Thomas W. Gould, Dante Heredia, Brian A. Perrino, Sung Jin Hwang, Sean M. Ward, Kenton M. Sanders
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(18)
The peristaltic reflex is a fundamental behavior of the gastrointestinal (GI) tract in which mucosal stimulation activates propulsive contractions. The reflex occurs by stimulation of intrinsic primary afferent neurons with cell bodies in the myenter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657264fb60edc15c527ef4af1bfbfcde
https://pubmed.ncbi.nlm.nih.gov/35446689
https://pubmed.ncbi.nlm.nih.gov/35446689
Autor:
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva
Publikováno v:
Frontiers in physiology. 13
Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ba44244930eaba3805b6864eec0ab7
https://pubmed.ncbi.nlm.nih.gov/35784885
https://pubmed.ncbi.nlm.nih.gov/35784885
Autor:
Haeyeong Lee, Byoung H. Koh, Lauren E. Peri, Holly J. Woodward, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Publikováno v:
Lee, H, Koh, B H, Peri, L E, Woodward, H J, Perrino, B A, Sanders, K M & Koh, S D 2022, ' Role of detrusor PDGFRα+ cells in mouse model of cyclophosphamide-induced detrusor overactivity ', Scientific Reports, vol. 12, no. 1, 5071 . https://doi.org/10.1038/s41598-022-09155-3
Cyclophosphamide (CYP)-induced cystitis is a rodent model that shares many features common to the cystitis occurring in patients, including detrusor overactivity (DO). Platelet-derived growth factor receptor alpha positive (PDGFRα+) cells have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8595c6017a3ddea499c9c8851570385
https://www.pure.ed.ac.uk/ws/files/259220890/s41598_022_09155_3.pdf
https://www.pure.ed.ac.uk/ws/files/259220890/s41598_022_09155_3.pdf
