Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Brian A Nadeau"'
Autor:
Daniel Rittirsch, Michael A Flierl, Danielle E Day, Brian A Nadeau, Firas S Zetoune, J Vidya Sarma, Clement M Werner, Guido A Wanner, Hans-Peter Simmen, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000464 (2009)
Pathogen-pattern-recognition by Toll-like receptors (TLRs) and pathogen clearance after immune complex formation via engagement with Fc receptors (FcRs) represent central mechanisms that trigger the immune and inflammatory responses. In the present s
Externí odkaz:
https://doaj.org/article/d667dbf35ae5439f9553526899f07d07
Autor:
Michael A Flierl, Daniel Rittirsch, Brian A Nadeau, J Vidya Sarma, Danielle E Day, Alex B Lentsch, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4414 (2009)
Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced re
Externí odkaz:
https://doaj.org/article/53adeecc77f5476e864667a26cff11c3
Autor:
Michael A Flierl, Daniel Rittirsch, Anthony J Chen, Brian A Nadeau, Danielle E Day, J Vidya Sarma, Markus S Huber-Lang, Peter A Ward
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2560 (2008)
Sepsis remains a poorly understood, enigmatic disease. One of the cascades crucially involved in its pathogenesis is the complement system. Especially the anaphylatoxin C5a has been shown to have numerous harmful effects during sepsis. We have invest
Externí odkaz:
https://doaj.org/article/d4d89b11d81e42878bebbe5856046b62
Publikováno v:
Seminars in Liver Disease. 38:366-378
Immune checkpoint inhibition targeted against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) has shown clinically significant survival benefit when used to treat multiple types of advanced cancer. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121f53af57cece5fa4aaae8dc1e94cac
https://doi.org/10.1055/s-0038-1667358
https://doi.org/10.1055/s-0038-1667358
Publikováno v:
Nutrients
Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease (NAFLD), as this can lead to the significant improvement or resolution of disease. The opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae87d1f4eb3ee1e54bcc7625a3e30c12
http://europepmc.org/articles/PMC6950283
http://europepmc.org/articles/PMC6950283
Publikováno v:
Gastroenterology. 158:S-1424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f16f2e7bbe3d5668241a024c7ed2ca4
https://doi.org/10.1016/s0016-5085(20)34229-3
https://doi.org/10.1016/s0016-5085(20)34229-3
Autor:
Hari Conjeevaram, Brian A. Nadeau
Publikováno v:
Clinical liver disease. 10(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9deb4fdb911ccb60b0ac72fb242aa724
https://pubmed.ncbi.nlm.nih.gov/30992769
https://pubmed.ncbi.nlm.nih.gov/30992769
Autor:
Jamison J. Grailer, Michael A. Flierl, Markus Huber-Lang, Brian A. Nadeau, Daniel Rittirsch, Alessio Fasano, Peter A. Ward, Firas S. Zetoune, Anuska V. Andjelkovic, Danielle E. Day
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L863-L872
Zonulin is a protein involved in the regulation of tight junctions (TJ) in epithelial or endothelial cells. Zonulin is known to affect TJ in gut epithelial cells, but little is known about its influences in other organs. Prehaptoglobin2 has been iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a81161d0035a5483a601a03b2d8ecdb
https://doi.org/10.1152/ajplung.00196.2012
https://doi.org/10.1152/ajplung.00196.2012
Autor:
Michael A. Flierl, Brian A. Nadeau, J. Vidya Sarma, Markus Huber-Lang, Peter A. Ward, Firas S. Zetoune, Daniel Rittirsch, Danielle E. Day
Publikováno v:
The FASEB Journal. 22:3483-3490
Activation of the complement system is a key event in the pathogenesis of sepsis. Nevertheless, the exact mechanisms remain inadequately understood. In the current study, we examined the role of complement C3 and C5 in sepsis in wild-type and C3- or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5365a7e4142b4cc72267c9c55a42bae1
https://doi.org/10.1096/fj.08-110595
https://doi.org/10.1096/fj.08-110595
Autor:
Laszlo M. Hoesel, Danielle E. Day, Lin Leng, Kyros Ipaktchi, Brian A. Nadeau, Thomas A. Neff, Stephanie R. McGuire, J. Vidya Sarma, Markus Huber-Lang, Michael A. Flierl, Richard Bucala, Firas S. Zetoune, Peter A. Ward, Daniel Rittirsch
Publikováno v:
The Journal of Immunology. 180:7664-7672
Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is poorly understood. Airway instillation of bacterial LPS, a known complement activator, represents a frequently used model of ALI. In the present study, pathways i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f62570c26bb20904eea7ed1823c81d
https://doi.org/10.4049/jimmunol.180.11.7664
https://doi.org/10.4049/jimmunol.180.11.7664