Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brian A M, Rudd"'
Autor:
David Noble, Delwyn R. Evans, Simon Baumberg, Brian A. M. Rudd, Jonathan H. Cove, Richard B. Herbert, Elizabeth A. Southey, Michael J. Dawson, Antony D. Buss
Publikováno v:
Tetrahedron Letters. 36:2351-2354
L-Histidine (4) is the source in Streptomyces tendae for the imidazolone moiety (1) of nikkomycin X (2). It is deduced to be incorporated with stereospecific retention of the β - pro - S proton. Histamine (5), 4-formylimidazole (7) and 4-hydroxymeth
Publikováno v:
Microbiology. 140:311-320
Summary: From a partial Sau3AI library of Streptomyces coelicolor A3(2) DNA in pIJ916, two hybrid plasmids pGX1 and pGX2 were isolated that complemented S. coelicolor A3(2) or S. lividans arginine auxotrophs. Subcloning DNA from pGX1 in the Escherich
Autor:
Steven, Boakes, Markiyan, Oliynyk, Jesús, Cortés, Ines, Böhm, Brian A M, Rudd, W Peter, Revill, Jim, Staunton, Peter F, Leadlay
Publikováno v:
Journal of molecular microbiology and biotechnology. 8(2)
A previously unidentified set of genes encoding a modular polyketide synthase (PKS) has been sequenced in Saccharopolyspora erythraea, producer of the antibiotic erythromycin. This new PKS gene cluster (pke) contains four adjacent large open reading
Autor:
Jesús, Cortés, Javier, Velasco, Graham, Foster, Andrew P, Blackaby, Brian A M, Rudd, Barrie, Wilkinson
Publikováno v:
Molecular microbiology. 44(5)
The soluble, diffusible red-brown pigment produced by a Saccharopolyspora erythraea "red variant" has been shown to contain glycosylated and polymerized derivatives of 2,5,7-trihydroxy-1,4-naphthoquinone (flaviolin). Flaviolin is a spontaneous oxidat
Autor:
Michael J. Dawson, P. A. Chalk, H. M. Noble, Howard G. Wildman, C. Stylli, M. V. Hayes, Brian A. M. Rudd, B. Lamont, A. Shuttleworth, H. C. Jackson, Oonagh S. Kinsman, S. Lynn, Carol A. Jones, Philip J. Sidebottom, R. F. Middleton
Publikováno v:
Europe PubMed Central
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococc
Publikováno v:
The Journal of antibiotics. 45(9)
The biosynthetic origin of the carbon and oxygen atoms of the novel fungal secondary metabolite 1 was studied. Incorporation studies with single and multiple labelled 13C precursors indicated that the major portion of the molecule was derived from tw
Publikováno v:
Journal of general microbiology. 137(10)
Transformation of the thermotolerant streptomycete, soil isolate S541, with plasmid cloning vectors of varying size, copy number, and parent replicon (derived from pIJ101, SCP2* and SLP1.2) depressed the biosynthesis of nemadectins (polyketide-derive
Publikováno v:
The Journal of Antibiotics. 40:340-347
From two types of class V act mutants of Streptomyces coelicolor two monomeric precursors of actinorhodin have been isolated and their structures determined. One is the known antibiotic kalafungin and the other a new compound. Their relationship to a
Autor:
Satoshi Omura, H. M. Kieser, Heinz G. Floss, J. Duncan, Brian A. M. Rudd, Haruo Ikeda, David A. Hopwood, I. Fujii, Francisco Malpartida
Publikováno v:
Nature. 314:642-644
The recent development of molecular cloning systems in Streptomyces has made possible the isolation of biosynthetic genes for some of the many antibiotics produced by members of this important genus of bacteria. Such clones can now be used to test th
Publikováno v:
Chemischer Informationsdienst. 12