Výsledky vyhledávání - "Brian A Link"

Akademický článek

Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation.

Autor: Nicholas J Hanovice, Lyndsay L Leach, Kayleigh Slater, Ana E Gabriel, Dwight Romanovicz, Enhua Shao, Ross Collery, Edward A Burton, Kira L Lathrop, Brian A Link, Jeffrey M Gross

Publikováno v: PLoS Genetics, Vol 15, Iss 1, p e1007939 (2019)

The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function. Diseases affecting the RPE have dire consequences for vision, and the most prevalent of these i

Externí odkaz: https://doaj.org/article/773a2271180d4bd0950ffb0b65f6dfa8

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Akademický článek

DEK regulates B-cell proliferative capacity and is associated with aggressive disease in low-grade B-cell lymphomas

Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract This study sheds light on the pivotal role of the oncoprotein DEK in B-cell lymphoma. We reveal DEK expression correlates with increased tumor proliferation and inferior overall survival in cases diagnosed with low-grade B-cell lymphoma (LGB

Externí odkaz: https://doaj.org/article/f182ba8954cf4fb28cf580c064a3c7cd

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Akademický článek

Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Immunochemotherapy has been the mainstay of treatment for newly diagnosed diffuse large B-cell lymphoma (ndDLBCL) yet is inadequate for many patients. In this work, we perform unsupervised clustering on transcriptomic features from a large c

Externí odkaz: https://doaj.org/article/4dae5fe5634e4259b6d610f0ad207e8d

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Akademický článek

Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL

Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide anticipatory selection of novel therapies. To address this unmet need, we used an int

Externí odkaz: https://doaj.org/article/01ad00fd8b6b4753b3568b00e0172eef

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Akademický článek

Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization.

Autor: Ross F Collery, Kerry N Veth, Adam M Dubis, Joseph Carroll, Brian A Link

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110699 (2014)

Refractive errors in vision can be caused by aberrant axial length of the eye, irregular corneal shape, or lens abnormalities. Causes of eye length overgrowth include multiple genetic loci, and visual parameters. We evaluate zebrafish as a potential

Externí odkaz: https://doaj.org/article/a12d8af3e97340bc9c4e0b3312620da3

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Akademický článek

Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics.

Autor: Jeremiah D Paulus, Brian A Link

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109922 (2014)

Mutations in Optineurin have been associated with ALS, glaucoma, and Paget's disease of bone in humans, but little is known about how these mutations contribute to disease. Most of the cellular consequences of Optineurin loss have come from in vitro

Externí odkaz: https://doaj.org/article/0f3ab8e00b5a422c933d91af9867d9b3

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Akademický článek

Marginal zone lymphoma international prognostic index: a unifying prognostic index for marginal zone lymphomas requiring systemic treatmentResearch in context

Publikováno v: EClinicalMedicine, Vol 72, Iss , Pp 102592- (2024)

Summary: Background: Marginal zone lymphomas (MZL), comprised of three unique but related subtypes, lack a unifying prognostic score applicable to all the patients in need for systemic chemotherapy and/or immunotherapy. Methods: Patients from the pro

Externí odkaz: https://doaj.org/article/131b6a9da7b1426a967e61af7173f6d4

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Akademický článek

Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium

Publikováno v: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-12 (2023)

Abstract Background Patients with mantle cell lymphoma (MCL) exhibit a wide variation in clinical presentation and outcome. However, the commonly used prognostic models are outdated and inadequate to address the needs of the current multidisciplinary

Externí odkaz: https://doaj.org/article/38f17dfbe7af46e394e36a8885eeec63

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Akademický článek

Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma.

Autor: Kerry N Veth, Jason R Willer, Ross F Collery, Matthew P Gray, Gregory B Willer, Daniel S Wagner, Mary C Mullins, Ava J Udvadia, Richard S Smith, Simon W M John, Ronald G Gregg, Brian A Link

Publikováno v: PLoS Genetics, Vol 7, Iss 2, p e1001310 (2011)

The glaucomas comprise a genetically complex group of retinal neuropathies that typically occur late in life and are characterized by progressive pathology of the optic nerve head and degeneration of retinal ganglion cells. In addition to age and fam

Externí odkaz: https://doaj.org/article/38ba329e10954c9f95fdf5132f63c35f

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