Zobrazeno 1 - 10
of 641
pro vyhledávání: '"Brian A Kennedy"'
Autor:
Aarthi Ravikrishnan, Indrik Wijaya, Eileen Png, Kern Rei Chng, Eliza Xin Pei Ho, Amanda Hui Qi Ng, Ahmad Nazri Mohamed Naim, Jean-Sebastien Gounot, Shou Ping Guan, Jasinda Lee Hanqing, Lihuan Guan, Chenhao Li, Jia Yu Koh, Paola Florez de Sessions, Woon-Puay Koh, Lei Feng, Tze Pin Ng, Anis Larbi, Andrea B. Maier, Brian K. Kennedy, Niranjan Nagarajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While rapid demographic changes in Asia are driving the incidence of chronic aging-related diseases, the limited availability of high-quality in vivo data hampers our ability to understand complex multi-factorial contributions, including gut
Externí odkaz:
https://doaj.org/article/847efc33d26e47edb08e63e509b16783
Autor:
Sheeja Navakkode, Brian K. Kennedy
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Ageing is characterized by a gradual decline in the efficiency of physiological functions and increased vulnerability to diseases. Ageing affects the entire body, including physical, mental, and social well-being, but its impact on the brain and cogn
Externí odkaz:
https://doaj.org/article/8f81cf2a5f2749d5b75d75e6c9714fd3
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103228- (2024)
Therapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and
Externí odkaz:
https://doaj.org/article/e31594045fb84e5f95e206917464a9a8
Publikováno v:
eLife, Vol 12 (2024)
Aging and senescence are characterized by pervasive transcriptional dysfunction, including increased expression of transposons and introns. Our aim was to elucidate mechanisms behind this increased expression. Most transposons are found within genes
Externí odkaz:
https://doaj.org/article/2b57d1c145b648d8b7946d59a7fc3cf5
Autor:
Brian A Kennedy, Daniel E Deatherage, Fei Gu, Binhua Tang, Michael W Y Chan, Kenneth P Nephew, Tim H-M Huang, Victor X Jin
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22606 (2011)
Deregulation of the transforming growth factor-β (TGFβ) signaling pathway in epithelial ovarian cancer has been reported, but the precise mechanism underlying disrupted TGFβ signaling in the disease remains unclear. We performed chromatin immunopr
Externí odkaz:
https://doaj.org/article/8b4b29ea02c0411c966c546bdf736d90
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/f200b2422d044eef8f591692e7cf975b
Autor:
Yuek Ling Chai, Jasinda H. Lee, Joyce R. Chong, Clive Ballard, Paul T. Francis, Brian K. Kennedy, Thiruma V. Arumugam, Christopher P. Chen, Dag Aarsland, Mitchell K. P. Lai
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background Chronically dysregulated neuroinflammation has been implicated in neurodegenerative dementias, with separate studies reporting increased brain levels of inflammatory mediators and gliosis in Alzheimer’s disease (AD) as well as i
Externí odkaz:
https://doaj.org/article/2a5cf1b0ed4d4f41a68dd14770553323
Autor:
Thiruma V Arumugam, Asfa Alli-Shaik, Elisa A Liehn, Sharmelee Selvaraji, Luting Poh, Vismitha Rajeev, Yoonsuk Cho, Yongeun Cho, Jongho Kim, Joonki Kim, Hannah LF Swa, David Tan Zhi Hao, Chutima Rattanasopa, David Yang-Wei Fann, David Castano Mayan, Gavin Yong-Quan Ng, Sang-Ha Baik, Karthik Mallilankaraman, Mathias Gelderblom, Grant R Drummond, Christopher G Sobey, Brian K Kennedy, Roshni R Singaraja, Mark P Mattson, Dong-Gyu Jo, Jayantha Gunaratne
Publikováno v:
eLife, Vol 12 (2023)
Intermittent fasting (IF) has been shown to reduce cardiovascular risk factors in both animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction. However, the underlying molecular mechanisms behind these
Externí odkaz:
https://doaj.org/article/77c3c141082e4538bda530d5762d0666
Autor:
Kaisy Xinhong Ye, Lina Sun, Su Lin Lim, Jialiang Li, Brian K. Kennedy, Andrea Britta Maier, Lei Feng
Publikováno v:
Nutrients, Vol 15, Iss 15, p 3446 (2023)
There is a lack of data on the adequacy of nutrient intake and prevalence of malnutrition risk in Asian populations. The aim was to report on the nutrient intake and prevalence of malnutrition risk in a community sample of older adults in Singapore.
Externí odkaz:
https://doaj.org/article/53f626890d144e0b809dd33e46d09c73
Autor:
Christine E. Robbins, Bhumil Patel, Danielle L. Sawyer, Barrie Wilkinson, Brian K. Kennedy, Mark A. McCormick
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105410- (2022)
Summary: Deletion of genes encoding ribosomal proteins extends lifespan in yeast. This increases translation of the functionally conserved transcription factor Gcn4, and lifespan extension in these mutants is GCN4-dependent. Gcn4 is also translationa
Externí odkaz:
https://doaj.org/article/4ba365963a08418e9b35c325ae632963