Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Brian A Kelch"'
Publikováno v:
eLife, Vol 11 (2022)
Clamp loaders place circular sliding clamp proteins onto DNA so that clamp-binding partner proteins can synthesize, scan, and repair the genome. DNA with nicks or small single-stranded gaps are common clamp-loading targets in DNA repair, yet these su
Externí odkaz:
https://doaj.org/article/d0c6503af28249db942b56b45d33c3d0
Autor:
Christl Gaubitz, Xingchen Liu, Joshua Pajak, Nicholas P Stone, Janelle A Hayes, Gabriel Demo, Brian A Kelch
Publikováno v:
eLife, Vol 11 (2022)
Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes. However, how a clamp loader opens and closes the
Externí odkaz:
https://doaj.org/article/5bda05abd9904a3888a3c73d20cdb5a4
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Viral capsids need to protect the genome against harsh environmental conditions and cope with high internal pressure from the packaged genome. Here, the authors determine the structure of the thermostable phage P74-26 capsid at 2.8-Å resolution and
Externí odkaz:
https://doaj.org/article/3c52f833affb4893b605b3ae7c48faca
Autor:
Tania V. Silvas, Shurong Hou, Wazo Myint, Ellen Nalivaika, Mohan Somasundaran, Brian A. Kelch, Hiroshi Matsuo, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s
Externí odkaz:
https://doaj.org/article/0666f6b6aeeb4da28babab14046087f4
Autor:
Takahide Kouno, Tania V. Silvas, Brendan J. Hilbert, Shivender M. D. Shandilya, Markus F. Bohn, Brian A. Kelch, William E. Royer, Mohan Somasundaran, Nese Kurt Yilmaz, Hiroshi Matsuo, Celia A. Schiffer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Cytidine deaminases are evolutionarily conserved enzymes that edit genomes by deaminating cytidine to uridine. Here the authors present the crystal structure of APOBEC3A with a single-stranded DNA substrate bound in the active site to shed light on t
Externí odkaz:
https://doaj.org/article/d9aff862807c4ea9832b5ce81ea7e7e9
Autor:
Sharon B. Cantor, Brian A. Kelch, Federica Piccioni, Cory M. Johannessen, Nicole S. Persky, Desiree Hernandez, Briana Fritchman, Jennifer A. Calvo
Information on FANCJ mutation library, including source of mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123fc5a70bc470f2046813076fbdcbe6
https://doi.org/10.1158/1541-7786.22526223
https://doi.org/10.1158/1541-7786.22526223
Autor:
Sharon B. Cantor, Brian A. Kelch, Federica Piccioni, Cory M. Johannessen, Nicole S. Persky, Desiree Hernandez, Briana Fritchman, Jennifer A. Calvo
Sensitivity data from validated FANCJ LOF mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bbde28b11a7332aff45c67d6e457fb
https://doi.org/10.1158/1541-7786.22526229
https://doi.org/10.1158/1541-7786.22526229
Autor:
Sharon B. Cantor, Brian A. Kelch, Federica Piccioni, Cory M. Johannessen, Nicole S. Persky, Desiree Hernandez, Briana Fritchman, Jennifer A. Calvo
FANCJ (BRIP1/BACH1) is a hereditary breast and ovarian cancer (HBOC) gene encoding a DNA helicase. Similar to HBOC genes, BRCA1 and BRCA2, FANCJ is critical for processing DNA inter-strand crosslinks (ICL) induced by chemotherapeutics, such as cispla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3dd83d2533f8b99633e364e147f2694
https://doi.org/10.1158/1541-7786.c.6545031.v1
https://doi.org/10.1158/1541-7786.c.6545031.v1
Autor:
Sharon B. Cantor, Brian A. Kelch, Federica Piccioni, Cory M. Johannessen, Nicole S. Persky, Desiree Hernandez, Briana Fritchman, Jennifer A. Calvo
Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d62179bfd86f8e1cd141822d10a7e6b
https://doi.org/10.1158/1541-7786.22526226
https://doi.org/10.1158/1541-7786.22526226
Autor:
Joseph Magrino, Veridiana Munford, Davi Jardim Martins, Thais K Homma, Brendan Page, Christl Gaubitz, Bruna L Freire, Antonio M Lerario, Juliana Brandstetter Vilar, Antonio Amorin, Emília K E Leão, Fernando Kok, Carlos F M Menck, Alexander A L Jorge, Brian A Kelch
SUMMARYProliferating Cell Nuclear Antigen (PCNA) is a sliding clamp protein that coordinates DNA replication with various DNA maintenance events that are critical for human health. Recently, a hypomorphic homozygous serine to isoleucine (S228I) subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76846f74e26876842a649b7e242911c
https://doi.org/10.1101/2022.10.20.22281069
https://doi.org/10.1101/2022.10.20.22281069