Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Brian A Hemmings"'
Autor:
Debora Schmitz-Rohmer, Simone Probst, Zhong-Zhou Yang, Frédéric Laurent, Michael B Stadler, Aimée Zuniga, Rolf Zeller, Debby Hynx, Brian A Hemmings, Alexander Hergovich
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136566 (2015)
Studies of mammalian tissue culture cells indicate that the conserved and distinct NDR isoforms, NDR1 and NDR2, play essential cell biological roles. However, mice lacking either Ndr1 or Ndr2 alone develop normally. Here, we studied the physiological
Externí odkaz:
https://doaj.org/article/654538069ff24c9aa7e82c33a337670c
Autor:
Yves Brand, Soledad Levano, Vesna Radojevic, Arianne Monge Naldi, Cristian Setz, Allen F Ryan, Kwang Pak, Brian A Hemmings, Daniel Bodmer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121599 (2015)
The kinase Akt is a key downstream mediator of the phosphoinositide-3-kinase signaling pathway and participates in a variety of cellular processes. Akt comprises three isoforms each encoded by a separate gene. There is evidence to indicate that Akt i
Externí odkaz:
https://doaj.org/article/cdd4a9f32b7e4d65be2e63e6405c1588
Autor:
Roland M Huber, Michal Rajski, Balasubramanian Sivasankaran, Gerald Moncayo, Brian A Hemmings, Adrian Merlo
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57793 (2013)
Glioblastoma (GBM) is a highly malignant primary tumor of the central nervous system originating in glial cells. GBM results in more years of life lost than any other cancer type. Low levels of Notch receptor expression correlates with prolonged surv
Externí odkaz:
https://doaj.org/article/b325cbee6cc34797837dff071908db3b
Autor:
Shuangshuang Lu, Junwei Nie, Qing Luan, Qiuting Feng, Qi Xiao, Zai Chang, Congjia Shan, Daniel Hess, Brian A Hemmings, Zhongzhou Yang
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19251 (2011)
The Twist1-family basic helix-loop-helix (bHLH) transcription factors including Twist1, Hand1 and Hand2, play an essential role in heart development and are implicated in pathological heart remodeling. Previously, it was reported that these bHLH tran
Externí odkaz:
https://doaj.org/article/aadb5c04ff40448f9578148357bf2e49
Autor:
Serdar Korur, Roland M Huber, Balasubramanian Sivasankaran, Michael Petrich, Pier Morin, Brian A Hemmings, Adrian Merlo, Maria Maddalena Lino
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7443 (2009)
Cancers are driven by a population of cells with the stem cell properties of self-renewal and unlimited growth. As a subpopulation within the tumor mass, these cells are believed to constitute a tumor cell reservoir. Pathways controlling the renewal
Externí odkaz:
https://doaj.org/article/a73b49b97ab54183acd4431e96a2dfa8
Autor:
Arnaud Parcellier, Lionel A Tintignac, Elena Zhuravleva, Bettina Dummler, Derek P Brazil, Debby Hynx, Peter Cron, Susanne Schenk, Vesna Olivieri, Brian A Hemmings
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5471 (2009)
BACKGROUND: Mitochondria are central to the metabolism of cells and participate in many regulatory and signaling events. They are looked upon as dynamic tubular networks. We showed recently that the Carboxy-Terminal Modulator Protein (CTMP) is a mito
Externí odkaz:
https://doaj.org/article/a0d3cbef915a41908fd032c7e51d73b3
Autor:
Elisabeth Fayard, Jason Gill, Magdalena Paolino, Debby Hynx, Georg A Holländer, Brian A Hemmings
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e992 (2007)
The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosphatidyl-inositol 3 kinase (PI3K) signaling pathway is involved in lymphoid development. Defects in single components of this pathway prevent thymocytes from progr
Externí odkaz:
https://doaj.org/article/3dc544cb0930423a9ba6de98559c1531
Autor:
Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani
Publikováno v:
PLoS Biology, Vol 5, Iss 4, p e95 (2007)
Protein kinase B (PKB/Akt) is a pivotal regulator of diverse metabolic, phenotypic, and antiapoptotic cellular controls and has been shown to be a key player in cancer progression. Here, using fluorescent reporters, we shown in cells that, contrary t
Externí odkaz:
https://doaj.org/article/78d28b5dc975472989d1bfb2e23028c6
Autor:
Brian A. Hemmings, Curzio Rüegg, Daniel Hess, Stephan Dirnhofer, Debby Hynx, Qiang Lan, David F. Restuccia, Gongda Xue
PDF file - 1.2MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648ebbc147758c8675e400fd31fe0f4d
https://doi.org/10.1158/2159-8290.22533026.v1
https://doi.org/10.1158/2159-8290.22533026.v1
Autor:
Debora Schmitz-Rohmer, Brian A. Hemmings, Stephan Frank, Alexander Hergovich, Christian Hundsrucker, Peter D. Cron, Yuhua Wang, Debby Hynx, Gongda Xue, Lei Zhang, Fengyuan Tang
PDF file - 500KB, Supplemental Figure 1. Upregulation of hMOB3 in GBM and characterization of hMOB3 antibody and shRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3bb092da52ca76ba0dc8409729fe94
https://doi.org/10.1158/0008-5472.22404285
https://doi.org/10.1158/0008-5472.22404285