Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Brian A Cobb"'
Publikováno v:
eLife, Vol 10 (2021)
Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge about the function of each cytokine and the signaling propagated downstream of their recogni
Externí odkaz:
https://doaj.org/article/2ae5ce3586bd49bba8f5b411902047ae
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216893 (2019)
CD4+ effector/memory T cells (Tem) represent a leading edge of the adaptive immune system responsible for protecting the body from infection, cancer, and other damaging processes. However, a subset of Tem cells with low expression of CD45Rb (RbLoTem)
Externí odkaz:
https://doaj.org/article/3738d088499347a8b669a2137a4968c2
Autor:
Janice C Jun, Mark B Jones, Douglas M Oswald, Edward S Sim, Amruth R Jonnalagadda, Lori S C Kreisman, Brian A Cobb
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180688 (2017)
While Toll-like receptors (TLRs) represent one of the best characterized innate immune pathways, evidence suggests that TLRs are not restricted to innate leukocytes and some epithelial cells, but are also expressed in T cells. Specifically, published
Externí odkaz:
https://doaj.org/article/16969ab2b87946adb3d6aea1fa4924b1
Autor:
Xiangzhu Xiao, Jue Yuan, Stéphane Haïk, Ignazio Cali, Yian Zhan, Mohammed Moudjou, Baiya Li, Jean-Louis Laplanche, Hubert Laude, Jan Langeveld, Pierluigi Gambetti, Tetsuyuki Kitamoto, Qingzhong Kong, Jean-Philippe Brandel, Brian A Cobb, Robert B Petersen, Wen-Quan Zou
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58786 (2013)
The four glycoforms of the cellular prion protein (PrP(C)) variably glycosylated at the two N-linked glycosylation sites are converted into their pathological forms (PrP(Sc)) in most cases of sporadic prion diseases. However, a prominent molecular ch
Externí odkaz:
https://doaj.org/article/52b7d62c2bc9412d93e1ea7587a84212
Autor:
Carlos A. Alvarez, Emily Qian, Leandre M. Glendenning, Kalob M. Reynero, Emily N. Kukan, Brian A. Cobb
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia. Changes in hyaluronin p
Externí odkaz:
https://doaj.org/article/f074b292f441464d847bd4fafb890941
Autor:
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Bäumler
Publikováno v:
mBio, vol 13, iss 6
Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures. It is therefore paradoxical that Salmonella enterica subspecies enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691042b2bc282ee5f0020ae446ff48c9
https://escholarship.org/uc/item/5xk6v9d8
https://escholarship.org/uc/item/5xk6v9d8
Autor:
Julie Y Zhou, David Zhou, Kevin Telfer, Kalob Reynero, Mark B Jones, John Hambor, Brian A Cobb
Publikováno v:
Glycobiology
Polysaccharide A (PSA) is the immunodominant capsular carbohydrate from the gram negative commensal microbe Bacteroides fragilis that has shown remarkable potency in ameliorating many rodent models of inflammatory disease by eliciting downstream supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c573d7331dbafae7e4c10057d000f
https://doi.org/10.1093/glycob/cwab111
https://doi.org/10.1093/glycob/cwab111
Autor:
Douglas M Oswald, Sylvain D Lehoux, Julie Y Zhou, Leandre M Glendenning, Richard D Cummings, Brian A Cobb
Publikováno v:
Glycobiology
The glycosylation of immunoglobulin G (IgG) has attracted increased attention due to the impact of N-glycan modifications at N297 on IgG function, acting primarily through modulation of Fc domain conformation and Fcγ receptor-binding affinities and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e949dab7ee2d6fe1d85253a148e47
https://doi.org/10.1093/glycob/cwac039
https://doi.org/10.1093/glycob/cwac039
Autor:
Brian A. Cobb, Julie Y. Zhou
Publikováno v:
Annual Review of Immunology. 39:511-536
The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2f87aff4d9beea88b7b8f94235152
https://doi.org/10.1146/annurev-immunol-101819-074237
https://doi.org/10.1146/annurev-immunol-101819-074237
Publikováno v:
Journal of leukocyte biology. 112(6)
The degree of α2,6-linked sialylation on IgG glycans is associated with a variety of inflammatory conditions and is thought to drive IgG anti-inflammatory activity. Previous findings revealed that ablation of β-galactoside α2,6-sialyltransferase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fd23daad46c7bbfd25700a75ae49eb
https://pubmed.ncbi.nlm.nih.gov/35726710
https://pubmed.ncbi.nlm.nih.gov/35726710