Zobrazeno 1 - 10
of 458
pro vyhledávání: '"Brian A Alexander"'
Autor:
Steffen Ventz, Sean Khozin, Bill Louv, Jacob Sands, Patrick Y. Wen, Rifaquat Rahman, Leah Comment, Brian M. Alexander, Lorenzo Trippa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Patient-level external control data from prior clinical studies or electronic health records can be used in the design and analysis of clinical trials. Here the authors report a hybrid trial design combining the use of external control data and rando
Externí odkaz:
https://doaj.org/article/0410f9fb573c42db83a9b7789d1d99ad
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Analysis of more than 150 Phase 3 oncology clinical trials supports parametric statistical analysis, significantly increasing the precision of small early-phase trials and relating deviations from the Cox proportional hazards model to trial duration.
Externí odkaz:
https://doaj.org/article/46788d6dbdbd4d7d851a4eef8e861c6a
Autor:
Andrea Necchi, Giuseppe Basile, Filippo Pederzoli, Marco Bandini, Petros Grivas, Gennady Bratslavsky, Philippe E. Spiess, J. Keith Killian, Douglas I. Lin, Erik Williams, Shakti Ramkissoon, Eric A. Severson, Brian M. Alexander, Jeffrey Venstrom, Prasanth Reddy, Kimberley McGregor, Julia A. Elvin, Alexa B. Schrock, Dean V. Pavlick, Dexter X. Jin, Sally E. Trabucco, Natalie Danzinger, Jeffrey S. Ross
Publikováno v:
Société Internationale d’Urologie Journal, Vol 2, Iss 4, Pp 216-228 (2021)
BackgroundAdult primary retroperitoneal sarcomas (RPSs) are a group of heterogeneous tumors with different histological subtypes. Comprehensive genomic profiling (CGP) analyses have recently provided significant insights into the biology of sarcomas
Externí odkaz:
https://doaj.org/article/25378e6a34274358be41fcc2afedd659
Autor:
Steffen Ventz, Sergio Bacallado, Rifaquat Rahman, Sara Tolaney, Jonathan D. Schoenfeld, Brian M. Alexander, Lorenzo Trippa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Sharing early evidence, as a trial is ongoing, is fundamental for both physicians and patients to make enrollment decisions. Here, the authors report the results of a simulation study evaluating the potential effects of early release of interim effic
Externí odkaz:
https://doaj.org/article/5b2e148bb2bf42bea0f1cf4c30ece8d0
Autor:
Erik A. Williams, Sandro Santagata, Hiroaki Wakimoto, Ganesh M. Shankar, Fred G. Barker, Radwa Sharaf, Abhinav Reddy, Phoebe Spear, Brian M. Alexander, Jeffrey S. Ross, Priscilla K. Brastianos, Daniel P. Cahill, Shakti H. Ramkissoon, Tareq A. Juratli
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract Background Genomic studies of high-grade/progressive meningiomas have reported a heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies have been underpowered to detect genomic subclasses of aggressive menin
Externí odkaz:
https://doaj.org/article/35b60a8f99044ddca1ea6cdff6638aa2
Autor:
Jonathan W. Riess, Shaila Rahman, Waleed Kian, Claire Edgerly, Andreas M. Heilmann, Russell Madison, Shakti H. Ramkissoon, Shai Shlomi Klaitman, Jon H. Chung, Sally E. Trabucco, Dexter X. Jin, Brian M. Alexander, Samuel J. Klempner, Lee A. Albacker, Garrett M. Frampton, Laila C. Roisman, Vincent A. Miller, Jeffrey S. Ross, Alexa B. Schrock, Jeffrey P. Gregg, Nir Peled, Ethan S. Sokol, Siraj M. Ali
Publikováno v:
Translational Oncology, Vol 14, Iss 10, Pp 101184- (2021)
Background: The translocation t(15:19) produces the oncogenic BRD4-NUT fusion which is pathognomonic for NUT carcinoma (NC), which is a rare, but extremely aggressive solid tumor. Comprehensive genomic profiling (CGP) by hybrid-capture based next gen
Externí odkaz:
https://doaj.org/article/f78f81cbdd204e1789f4f2191a1fc032
Autor:
Rifaquat Rahman, Steffen Ventz, Robert Redd, Timothy Cloughesy, Brian M. Alexander, Patrick Y. Wen, Lorenzo Trippa
Publikováno v:
Clinical Cancer Research. :OF1-OF5
Drug development can be associated with slow timelines, particularly for rare or difficult-to-treat solid tumors such as glioblastoma. The use of external data in the design and analysis of trials has attracted significant interest because it has the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::765c84a3a26611bbe1e554d99e3cf5ed
https://doi.org/10.1158/1078-0432.ccr-22-3524
https://doi.org/10.1158/1078-0432.ccr-22-3524
Autor:
Rachna T. Shroff, Karyn A. Goodman, Janice M. Mehnert, Julie M. Vose, Susan E. Moran, Jennifer L. Yessaian, Lance Baldo, Brian M. Alexander, Quita B. Highsmith, Jennifer M. Mills, Pamela L. Kunz
Publikováno v:
Journal of Clinical Oncology. 41:1659-1663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8207b6899a7eccdb0ba3e3afb22b02e7
https://doi.org/10.1200/jco.21.02219
https://doi.org/10.1200/jco.21.02219
Autor:
Anne-Florence Blandin, Ross Giglio, Maya Srikanth Graham, Guadalupe Garcia, Seth Malinowski, Jared K. Woods, Shakti Ramkissoon, Lori Ramkissoon, Frank Dubois, Kathleen Schoolcraft, Jessica Tsai, Dayle Wang, Robert Jones, Jayne Vogelzang, Kristine Pelton, Sarah Becker, Fiona Watkinson, Claire Sinai, Elizabeth F. Cohen, Matthew A. Booker, Michael Y. Tolstorukov, Veerle Haemels, Liliana Goumnerova, Karen Wright, Mark Kieran, Katie Fehnel, David Reardon, Arnault Tauziede-Espariat, Rishi Lulla, Benjamin Carcamo, Stanley Chaleff, Alain Charest, Frederik De Smet, Azra H. Ligon, Adrian Dubuc, Melanie Pages, Pascale Varlet, Patrick Y. Wen, Brian M. Alexander, Susan Chi, Sanda Alexandrescu, Ralf Kittler, Robert Bachoo, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon
Publikováno v:
Clinical Cancer Research. :OF1-OF17
Purpose: Anaplastic lymphoma kinase (ALK) aberrations have been identified in pediatric-type infant gliomas, but their occurrence across age groups, functional effects, and treatment response has not been broadly established. Experimental Design: We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284b9c146f0dfa3d1d6edc1c4f96c9f1
https://doi.org/10.1158/1078-0432.ccr-21-3521
https://doi.org/10.1158/1078-0432.ccr-21-3521
Autor:
Vasyl Nesteryuk, Omar Hamdani, Raymond Gong, Nava Almog, Brian M. Alexander, Steffan Soosman, Ken Yoneda, Siraj M. Ali, Alexander D. Borowsky, Jonathan W. Riess
Publikováno v:
Clinical Lung Cancer. 23:e550-e555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78456e5b878fc15fbcbd78883218940
https://doi.org/10.1016/j.cllc.2022.09.001
https://doi.org/10.1016/j.cllc.2022.09.001