Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Brian A, Perrino"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Purinergic signaling is important for normal bladder function, as it is thought to initiate the voiding reflex and modulate smooth muscle tone. The availability of adenine nucleotides and nucleosides (aka purines) at receptor sites of various cell ty
Externí odkaz:
https://doaj.org/article/7ddc85ab543348b78751ed2057a2314f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protease-activated receptor-1 (PAR1) is highly expressed in murine colonic smooth muscles. Responses to PAR1 activation are complex and result from responses in multiple cell types. We investigated whether PAR1 responses are altered in infla
Externí odkaz:
https://doaj.org/article/4004c89198b04868adc8bee07b8f81b3
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1688 (2023)
The interplay of the enteric nervous system (ENS) and SIP syncytium (smooth muscle cells–interstitial cells of Cajal–PDGFRα+ cells) plays an important role in the regulation of gastrointestinal (GI) motility. This study aimed to investigate the
Externí odkaz:
https://doaj.org/article/bcb9d7e3e8714a56b0714789c0963ca2
Autor:
Haeyeong Lee, Byoung H. Koh, Lauren E. Peri, Holly J. Woodward, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Cyclophosphamide (CYP)-induced cystitis is a rodent model that shares many features common to the cystitis occurring in patients, including detrusor overactivity (DO). Platelet-derived growth factor receptor alpha positive (PDGFRα+) cells h
Externí odkaz:
https://doaj.org/article/2fec9f31909a46bb9ff04c8c8358e0b1
Autor:
Ken Lee, Sang O Park, Pil-Cho Choi, Seung-Bum Ryoo, Haeyeong Lee, Lauren E. Peri, Tong Zhou, Robert D. Corrigan, Andrew C. Yanez, Suk B. Moon, Brian A. Perrino, Kenton M. Sanders, Sang Don Koh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Volume accommodation occurs via a novel mechanism involving interstitial cells in detrusor muscles. The interstitial cells in the bladder are PDGFRα+, and they restrain the excitability of smooth muscle at low levels and prevents the develo
Externí odkaz:
https://doaj.org/article/2ffc5cafa1a74f33afd2860ded277ffe
Autor:
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many
Externí odkaz:
https://doaj.org/article/a0b190b0eac343d5893a31fa8d2e3437
Autor:
Alejandro Gutierrez Cruz, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, Violeta N. Mutafova-Yambolieva
Publikováno v:
Metabolites, Vol 13, Iss 1, p 30 (2022)
Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urin
Externí odkaz:
https://doaj.org/article/b83f19e5c3b2449d8bd49bb35ce64f74
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C992-C1006
The main function of the stomach is to digest ingested food. Gastric antrum muscular contractions mix ingested food with digestive enzymes and stomach acid and propel the chyme through the pyloric sphincter at a rate in which the small intestine can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c649ea3cd44460e53466a5201f1985d1
https://doi.org/10.1152/ajpcell.00043.2023
https://doi.org/10.1152/ajpcell.00043.2023
Autor:
Haifeng Zheng, Bernard T. Drumm, Mei Hong Zhu, Yeming Xie, Kate E. O'Driscoll, Salah A. Baker, Brian A. Perrino, Sang Don Koh, Kenton M. Sanders
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/99cbcf3029a94b51933e5b28c45d8793
Autor:
Haifeng Zheng, Bernard T. Drumm, Mei Hong Zhu, Yeming Xie, Kate E. O’Driscoll, Salah A. Baker, Brian A. Perrino, Sang Don Koh, Kenton M. Sanders
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract. Slow waves depend upon
Externí odkaz:
https://doaj.org/article/e4bfb74ddf7a4fa28f3b24effc9b71b8