Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Brian A, MacVicar"'
Autor:
Stuart M. Cain, Sascha R. A. Alles, Ray Gopaul, Louis-Philippe Bernier, Andrew C. Yung, Andrew Bauman, Yi Yang, Glen B. Baker, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium channel. Pregabalin, used clinically in the treatment of chronic pain and epilepsy, inhibits P/Q-t
Externí odkaz:
https://doaj.org/article/7f60fbce64114253a4fc70c967d52dd5
Autor:
Nicholas L. Weilinger, Kai Yang, Hyun B. Choi, Christopher J. Groten, Stefan Wendt, Madhuvika Murugan, Leigh E. Wicki-Stordeur, Louis-Philippe Bernier, Prashanth S. Velayudhan, Jiaying Zheng, Jeffrey M. LeDue, Ravi L. Rungta, John R. Tyson, Terrance P. Snutch, Long-Jun Wu, Brian A. MacVicar
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113128- (2023)
Summary: Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown. Here, we investigate the role of large-conductance Pannexin-1 (Panx1) ch
Externí odkaz:
https://doaj.org/article/15c0151341174dd0a284baf30f872a0d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The importance of MCU-mediated mitochondrial Ca2+ uptake to the regulation of neuronal bioenergetics and excitability in the brain is demonstrated using single-cell patch-clamp recording and two-photon imaging.
Externí odkaz:
https://doaj.org/article/be69a4939da34bf2bc538d0f6081b0a8
Autor:
Christopher Lee, Jonathan Frew, Nicholas L. Weilinger, Stefan Wendt, Wenji Cai, Stefano Sorrentino, Xiujuan Wu, Brian A. MacVicar, Stephanie M. Willerth, Haakon B. Nygaard
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106124- (2023)
Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are characterized by pathology predominantly localized to the frontal and temporal lobes. Approximately 40% of FTD cases are familial, and up to 20% of these are caus
Externí odkaz:
https://doaj.org/article/a74313a8c4eb494ab8662323f265613e
Autor:
Stefan Wendt, Sora Johnson, Nicholas L. Weilinger, Christopher Groten, Stefano Sorrentino, Jonathan Frew, Lucy Yang, Hyun B. Choi, Haakon B. Nygaard, Brian A. MacVicar
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102448- (2022)
The inter-relationship between microglia dynamics and oxidative stress (Ox-stress) in dystrophic neurites (DNs) at Alzheimer’s Disease (AD) plaques may contribute to the pathological changes in neurons. We developed new in vivo imaging strategies t
Externí odkaz:
https://doaj.org/article/7fcc7bbc142e45448ec3f55b2091b1e9
Autor:
Michelle Zuo, Naomi M. Fettig, Louis-Philippe Bernier, Elisabeth Pössnecker, Shoshana Spring, Annie Pu, Xianjie I. Ma, Dennis S.W. Lee, Lesley A. Ward, Anshu Sharma, Jens Kuhle, John G. Sled, Anne-Katrin Pröbstel, Brian A. MacVicar, Lisa C. Osborne, Jennifer L. Gommerman, Valeria Ramaglia
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
People living with multiple sclerosis (MS) experience episodic CNS white matter lesions instigated by autoreactive T cells. With age, patients with MS show evidence of gray matter demyelination and experience devastating nonremitting symptomology. Wh
Externí odkaz:
https://doaj.org/article/3179dda5d85f4c3d98777afc0ce6961d
Autor:
Louis-Philippe Bernier, Elisa M. York, Alireza Kamyabi, Hyun B. Choi, Nicholas L. Weilinger, Brian A. MacVicar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Glucose is the main source of fuel in the brain. Here, the authors show that in the absence of glucose, glutamine is required for microglia to maintain their immune surveillance function.
Externí odkaz:
https://doaj.org/article/fe06297fc77c43a5ab302576cc98adf4
Autor:
Louis-Philippe Bernier, Christopher J. Bohlen, Elisa M. York, Hyun B. Choi, Alireza Kamyabi, Lasse Dissing-Olesen, Jasmin K. Hefendehl, Hannah Y. Collins, Beth Stevens, Ben A. Barres, Brian A. MacVicar
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 2895-2908.e4 (2019)
Summary: Microglia, the brain’s immune cells, maintain homeostasis and sense pathological changes by continuously surveying the parenchyma with highly motile large processes. Here, we demonstrate that microglia also use thin actin-dependent filopod
Externí odkaz:
https://doaj.org/article/f4a5ba30a4b14557bf6be3381040748f
Autor:
Mihai S. Cirstea, Daniel Kliger, Abbey D. MacLellan, Adam C. Yu, Jenna Langlois, Mannie Fan, Seti Boroomand, Faezeh Kharazyan, Robin G.Y. Hsiung, Brian A. MacVicar, Howard Chertkow, Victor Whitehead, B. Brett Finlay, Silke Appel-Cresswell
Publikováno v:
Journal of Alzheimer's Disease. 87:247-258
Background: Despite decades of research, our understanding of Alzheimer’s disease (AD) etiology remains incomplete. In recent years, appreciation has grown for potential roles for the microbiota in shaping neurological health. Objective: This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664dedcae373594e1d272807f1e1e7ce
https://doi.org/10.3233/jad-215520
https://doi.org/10.3233/jad-215520
Autor:
Christian C. Naus, Roberto Bruzzone, Brian A. MacVicar, Roger J. Thompson, John F. Bechberger, Charles P.K. Lai
Supplementary Table S1 from Tumor-Suppressive Effects of Pannexin 1 in C6 Glioma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cec11c1ac05e621ffd6ef7e50e57d7
https://doi.org/10.1158/0008-5472.22366698.v1
https://doi.org/10.1158/0008-5472.22366698.v1
