Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Brian A, Cobb"'
Autor:
Carlos A. Alvarez, Emily Qian, Leandre M. Glendenning, Kalob M. Reynero, Emily N. Kukan, Brian A. Cobb
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia. Changes in hyaluronin p
Externí odkaz:
https://doaj.org/article/f074b292f441464d847bd4fafb890941
Autor:
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Bäumler
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures. It is therefore paradoxical that Salmonella enterica subspec
Externí odkaz:
https://doaj.org/article/e99dffdba33f4422af13a6eeea71911f
Publikováno v:
eLife, Vol 10 (2021)
Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge about the function of each cytokine and the signaling propagated downstream of their recogni
Externí odkaz:
https://doaj.org/article/2ae5ce3586bd49bba8f5b411902047ae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Polysaccharide A (PSA), a capsular carbohydrate from the commensal gut bacteria Bacteroides fragilis, has been shown to possess both potent T cell-dependent pro- and anti-inflammatory properties. PSA is able to induce abscess and adhesion formation i
Externí odkaz:
https://doaj.org/article/f807ec67a9514c96879a5ad9e99246e9
Autor:
Hirotaka Hiyoshi, Tamding Wangdi, Gabriel Lock, Cheng Saechao, Manuela Raffatellu, Brian A. Cobb, Andreas J. Bäumler
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1787-1797 (2018)
Summary: Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars. The different clinical presentations are attribute
Externí odkaz:
https://doaj.org/article/bc527e6f2c4f46edba4e9089d70a00c9
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216893 (2019)
CD4+ effector/memory T cells (Tem) represent a leading edge of the adaptive immune system responsible for protecting the body from infection, cancer, and other damaging processes. However, a subset of Tem cells with low expression of CD45Rb (RbLoTem)
Externí odkaz:
https://doaj.org/article/3738d088499347a8b669a2137a4968c2
Autor:
Julie Y Zhou, David Zhou, Kevin Telfer, Kalob Reynero, Mark B Jones, John Hambor, Brian A Cobb
Publikováno v:
Glycobiology
Polysaccharide A (PSA) is the immunodominant capsular carbohydrate from the gram negative commensal microbe Bacteroides fragilis that has shown remarkable potency in ameliorating many rodent models of inflammatory disease by eliciting downstream supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c573d7331dbafae7e4c10057d000f
https://doi.org/10.1093/glycob/cwab111
https://doi.org/10.1093/glycob/cwab111
Autor:
Janice C Jun, Mark B Jones, Douglas M Oswald, Edward S Sim, Amruth R Jonnalagadda, Lori S C Kreisman, Brian A Cobb
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180688 (2017)
While Toll-like receptors (TLRs) represent one of the best characterized innate immune pathways, evidence suggests that TLRs are not restricted to innate leukocytes and some epithelial cells, but are also expressed in T cells. Specifically, published
Externí odkaz:
https://doaj.org/article/16969ab2b87946adb3d6aea1fa4924b1
Autor:
Brian A. Cobb, Julie Y. Zhou
Publikováno v:
Annual Review of Immunology. 39:511-536
The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2f87aff4d9beea88b7b8f94235152
https://doi.org/10.1146/annurev-immunol-101819-074237
https://doi.org/10.1146/annurev-immunol-101819-074237
Autor:
Douglas M Oswald, Sylvain D Lehoux, Julie Y Zhou, Leandre M Glendenning, Richard D Cummings, Brian A Cobb
Publikováno v:
Glycobiology
The glycosylation of immunoglobulin G (IgG) has attracted increased attention due to the impact of N-glycan modifications at N297 on IgG function, acting primarily through modulation of Fc domain conformation and Fcγ receptor-binding affinities and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e949dab7ee2d6fe1d85253a148e47
https://doi.org/10.1093/glycob/cwac039
https://doi.org/10.1093/glycob/cwac039