In Vivo Neutralization of Myotoxin II, a Phospholipase A2 Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology

Autor: Andreas H. Laustsen, Bengt H. Gless, Timothy P. Jenkins, Maria Meyhoff-Madsen, Johanna Bjärtun, Andreas S. Munk, Saioa Oscoz, Julián Fernández, José María Gutiérrez, Bruno Lomonte, Brian Lohse

Publikováno v: Laustsen, A H, Gless, B H, Jenkins, T P, Meyhoff-Madsen, M, Bjärtun, J, Munk, A S, Oscoz, S, Fernández, J, Gutiérrez, J M, Lomonte, B & Lohse, B 2022, ' In Vivo Neutralization of Myotoxin II, a Phospholipase A 2 Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology ', ACS Omega, vol. 7, no. 18, pp. 15561-15569 . https://doi.org/10.1021/acsomega.2c00280
Laustsen, A H, Gless, B H, Jenkins, T P, Meyhoff-Madsen, M, Bjärtun, J, Munk, A S, Oscoz, S, Fernández, J, Gutiérrez, J M, Lomonte, B & Lohse, B 2022, ' In Vivo Neutralization of Myotoxin II, a Phospholipase A 2 Homologue from Bothrops asper Venom, Using Peptides Discovered via Phage Display Technology ', ACS Omega, vol. 7, no. 18, pp. 15561–15569 . https://doi.org/10.1021/acsomega.2c00280

Many snake venom toxins cause local tissue damage in prey and victims, which constitutes an important pathology that is challenging to treat with existing antivenoms. One of the notorious toxins that causes such effects is myotoxin II present in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262510425775ec2cd24b5b175bbf54bc
https://orbit.dtu.dk/en/publications/49e5d43c-9c43-42bf-adc3-ef11dc0223a9

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

Autor: Andreas Hougaard Laustsen, Stephan A. Pless, Kanchan Devkota, Bengt H. Gless, Stephan Kiontke, Christian A. Olsen, Jónas Johannesen, Brian Lohse, Maria Meyhoff-Madsen, Martin Dufva, Daniel Kümmel, Timothy Lynagh, Sabrina Kattelmann, Anders Roy Christiansen

Publikováno v: Journal of Medicinal Chemistry
Lynagh, T, Kiontke, S, Meyhoff-Madsen, M, Gless, B H, Johannesen, J, Kattelmann, S, Christiansen, A, Dufva, M, Laustsen, A H, Devkota, K, Olsen, C A, Kümmel, D, Pless, S A & Lohse, B 2020, ' Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction ', Journal of Medicinal Chemistry, vol. 63, pp. 13709−13718 . https://doi.org/10.1021/acs.jmedchem.0c01202
Journal of medicinal chemistry 63(22), 13709-13718 (2020). doi:10.1021/acs.jmedchem.0c01202
Lynagh, T, Kiontke, S, Meyhoff-Madsen, M, Gless, B H, Johannesen, J, Kattelmann, S, Christiansen, A, Dufva, M, Laustsen, A H, Devkota, K, Olsen, C A, Kuemmel, D, Pless, S A & Lohse, B 2020, ' Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction ', Journal of Medicinal Chemistry, vol. 63, no. 22, pp. 13709-13718 . https://doi.org/10.1021/acs.jmedchem.0c01202
13709-13718

Journal of medicinal chemistry 63(22), 13709 - 13718 (2020). doi:10.1021/acs.jmedchem.0c01202
Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Eme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d58265b9716c307f44b73107314d0cb
https://pubmed.ncbi.nlm.nih.gov/33143415

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

Autor: Julián Fernández, Bruno Lomonte, José María Gutiérrez, Andreas Hougaard Laustsen, Brian Lohse

Publikováno v: Journal of Proteomics 119: 126-142
Kérwá
Universidad de Costa Rica
instacron:UCR

The venom proteome of the black mamba, Dendroaspis polylepis, from Eastern Africa, was, for the first time, characterized. Forty- different proteins and one nucleoside were identified or assigned to protein families. The most abundant proteins were K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe5c9ce74306d83b3f4daaedd158839
https://doi.org/10.1016/j.jprot.2015.02.002

Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

Autor: Brian Lohse, Kasper D. Rand, Jesper L. Kristensen, Shonoi Ming, Philip A. Cole, Ulrike Leurs, Rasmus P. Clausen

Publikováno v: Analytical Chemistry
Leurs, U, Lohse, B, Ming, S A, Cole, P A, Clausen, R P, Kristensen, J L & Rand, K D 2014, ' Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry ', Analytical Chemistry, vol. 86, no. 23, pp. 11734-11741 . https://doi.org/10.1021/ac503137u

Phage display (PD) is frequently used to discover peptides capable of binding to biological protein targets. The structural characterization of peptide-protein complexes is often challenging due to their low binding affinities and high structural fle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704f74fb1cd5c48737e100aaeb96351e
https://doi.org/10.1021/ac503137u

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

Autor: Bruno Lomonte, José María Gutiérrez, Andreas Hougaard Laustsen, Brian Lohse, Mikael Engmark

Publikováno v: Laustsen, A H, Lohse, B, Lomonte, B, Engmark, M & Maria Gutierrez, J 2015, ' Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score ', Toxicon, vol. 104, pp. 43-45 . https://doi.org/10.1016/j.toxicon.2015.07.334
Toxicon; Volumen 104. 2015
Kérwá
Universidad de Costa Rica
instacron:UCR

Carta al editor For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction of prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f143699bd6b7895c17da522a84519651
https://doi.org/10.1016/j.toxicon.2015.07.334