Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brian Chamberlain"'
Autor:
Bryce K. Allen, Meghana M. Kulkarni, Brian Chamberlain, Timothy Dwight, Cheryl Koh, Ramya Samant, Finith Jernigan, Jamie Rice, Dazhi Tan, Stella Li, Kristen Marino, Huang Huang, Evan Chiswick, Bethany Tesar, Sam Sparks, Zhixiong Lin, T. Dwight McGee, István Kolossváry, Charles Lin, Sharon Shechter, Holly Soutter, Cecilia Bastos, Mohammed Taimi, Sujen Lai, Alicia Petrin, Tracy Kane, Steven Swann, Humphrey Gardner, Christopher Winter, Woody Sherman
The protein STING (stimulator of interferon genes) is a central regulator of the innate immune system and plays an important role in antitumor immunity by inducing the production of cytokines such as type I interferon (IFN). Activation of STING stems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::007367283e6d03ce62189d7f16465731
https://doi.org/10.1101/2022.05.23.493001
https://doi.org/10.1101/2022.05.23.493001
Autor:
Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 58:8503-8512
The emergence and spread of multidrug resistant bacteria are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the discovery of azaindole u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b67169430f8d7544a01fb0b95c703d
https://doi.org/10.1021/acs.jmedchem.5b00961
https://doi.org/10.1021/acs.jmedchem.5b00961
Autor:
Jing Zhang, Jason B. Cross, Sabrina Stucka, Audrey Chan, Brian Chamberlain, Haoqun Chandonnet, Mustafa Varoglu, Lippa Blaise S, Dominic Ryan, Jan Antoinette C. Romero, Jennifer Goss
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3661-3664
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, affects millions of people worldwide. CCR9 has been shown to be a key chemokine receptor mediating the local inflammatory responses in the GI tract. The CCR9 inhibitor Verc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7661c28704533cf1030e6dc6213be0e1
https://doi.org/10.1016/j.bmcl.2015.06.046
https://doi.org/10.1016/j.bmcl.2015.06.046
Autor:
Katherine M. Poutsiaka, Lippa Blaise S, Haoqun Chandonnet, Timothy Hopper, Jing Zhang, Mustafa Varoglu, Jan Antoinette C. Romero, Sabrina Stucka, Jennifer Goss, Audrey Chan, Christian Baber, Brian Chamberlain, Bhaumik A. Pandya, Xin Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(14)
Irritable bowel diseases (IBD) such as Crohn's disease (CD) and ulcerative colitis (UC) are serious chronic diseases affecting millions of patients worldwide. Studies of human chemokine biology has suggested C-C chemokine receptor 9 (CCR9) may be a k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f76c35dc2c76efddca9b68935442f6c
https://pubmed.ncbi.nlm.nih.gov/27256913
https://pubmed.ncbi.nlm.nih.gov/27256913
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Autor:
Jan Antoinette C. Romero, Michael F. Mesleh, Douglas Bevan, Joseph Shotwell, Ole A. Andersen, Kien T. Nguyen, Bin Wang, Jing Zhang, Katherine M. Poutsiaka, Qingyi Yang, Anu Daniel, Brian Chamberlain, Lippa Blaise S, Nicole M. Carter, Roland E. Dolle, Terence Moy, Chester A. Metcalf, Jason B. Cross, John J. Barker, M. Dominic Ryan, Jared Silverman, Felix Epie
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461bdfd2f15b29c8a0f1afd5fa1ba2d4
https://europepmc.org/articles/PMC4834655/
https://europepmc.org/articles/PMC4834655/
Autor:
Anu Daniel, Chester A. Metcalf, Qingyi Yang, Roland E. Dolle, Jared Silverman, Felix Epie, Anu Arya, Jan Antoinette C. Romero, Kien T. Nguyen, Lippa Blaise S, Terence Moy, Yuchuan Wu, Jason B. Cross, Dominic Ryan, Joseph Shotwell, Douglas Bevan, Brian Chamberlain, Jing Zhang, Nicole M. Carter, Vipul Kumar, Bin Wang, Katherine M. Poutsiaka
Publikováno v:
ACS medicinal chemistry letters. 6(10)
Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically validated target. Through physiochemical property optimization of a pyrazolopyridone hit, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52605f8eb4df90c1087a81076555cf21
https://pubmed.ncbi.nlm.nih.gov/26487916
https://pubmed.ncbi.nlm.nih.gov/26487916
Autor:
Simon N. Young, Brian Chamberlain, Robert O. Pihl, Frank R. Ervin, Stewart Plotnick, Philip W. Harden
Publikováno v:
Psychopharmacology. 119:353-360
Normal males received amino acid mixtures designed to raise or lower tryptophan availability, and thus to raise or lower brain serotonin synthesis. They also received alcoholic or non-alcoholic drinks. The subjects were tested in the Taylor Competiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a86b074aade406e78820ed3e681085
https://doi.org/10.1007/bf02245849
https://doi.org/10.1007/bf02245849
Autor:
Jing Zhang, Qingyi Yang, Jason B. Cross, Jan AntoinetteC. Romero, Katherine M. Poutsiaka, Felix Epie, Douglas Bevan, Bin Wang, Yanzhi Zhang, Ajit Chavan, Xin Zhang, Terence Moy, Anu Daniel, Kien Nguyen, Brian Chamberlain, Nicole Carter, Joseph Shotwell, Jared Silverman, Chester A. Metcalf, Dominic Ryan
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8503-8512, 10p
Publikováno v:
Pharmacology, biochemistry, and behavior. 28(4)
were given amino acid mixtures that were tryptophan-free (T-), nutritionally balanced (B), or contained excess tryptophan (T+). The T- mixture caused a marked decrease in plasma tryptophan and the T+ mixture a large increase. Behavioral observations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9516396d6de4bae8a3289b4d7434e452
https://pubmed.ncbi.nlm.nih.gov/3432316
https://pubmed.ncbi.nlm.nih.gov/3432316
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