Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brian, Schlain"'
Autor:
Douglas Donaldson, Alvydas Mikulskis, David Yeung, Chase Shen, Shobha Purushothama, Shawn Ciotti, Geoffrey Kuesters, Brian Schlain, Elham Gharakhani
Publikováno v:
Journal of Immunological Methods. 437:53-63
A comprehensive cross-platform and cross-assay evaluation using nine technology platforms and four cytokine immunoassays (IL-6, TNFα, IL-17a, IL-2) was performed by comparing assay precision, sensitivity, parallelism and data correlation between pla
Autor:
Melissa Berman, Brian Schlain, Tatiana Plavina, Peter T. Lee, Dipeshkumar Jaiswal, Albert Castro, Suzanne Rivas, Meena Subramanyam
Publikováno v:
Journal of Clinical Virology. 57:141-146
Background JC virus (JCV) infection is a prerequisite for development of progressive multifocal leukoencephalopathy (PML). The development and validation of a two-step enzyme-linked immunosorbent assay (ELISA) that detects JCV antibodies in human ser
Multi-site analytical validation of an assay to detect anti-JCV antibodies in human serum and plasma
Autor:
Brian Schlain, Moses Njenga, Meena Subramanyam, Melissa Berman, Mary Crossman, Leonid Gorelik, Michaela Lerner, Tatiana Plavina, Kenneth Simon
Publikováno v:
Journal of Clinical Virology. 53:65-71
Background JC virus (JCV) infection is a prerequisite for development of progressive multifocal leukoencephalopathy (PML). We previously described the development of a novel, two-step enzyme-linked immunosorbent assay (ELISA) that detects anti-JCV an
Autor:
Matthew Jarpe, Frederique Bard, Brian Schlain, Ruth Motter, Ellen Garber, Renee I. Shapiro, Frederick R. Taylor, Ted Yednock, R. Blake Pepinsky, Paula S. Hochman, Tatiana Plavina, Nancy G. Wehner
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 55:168-175
Natalizumab is a humanized IgG4 monoclonal antibody which binds human α4 integrin and is approved for treatment of multiple sclerosis and Crohn's disease. Assessment of the in vivo disposition of natalizumab presents a unique assay development chall
Autor:
Meena Subramanyam, Lakshmi Amaravadi, Jean Donley, Brian Schlain, Ananda Wickramasekera, Donald Bennett
Publikováno v:
Journal of Immunological Methods. 352:161-168
In recent years there has been growing recognition of the impact of anti-drug or anti-therapeutic antibodies (ADAs, ATAs) on the pharmacokinetic and pharmacodynamic behavior of the drug, which ultimately affects drug exposure and activity. These anti
Autor:
Brian Schlain, James Davenport
Publikováno v:
Clinical Chemistry. 46:1669-1680
Manufacturers and users of medical diagnostic devices are provided a statistical decision tool for investigating a claimed minimal detectable concentration (MDC). The MDC is defined by setting two respective probabilities: that the blank sample being
Autor:
Leonid, Gorelik, Michaela, Lerner, Sarah, Bixler, Mary, Crossman, Brian, Schlain, Kenneth, Simon, Amy, Pace, Anne, Cheung, Ling Ling, Chen, Melissa, Berman, Fairuz, Zein, Ewa, Wilson, Ted, Yednock, Alfred, Sandrock, Susan E, Goelz, Meena, Subramanyam
Publikováno v:
Annals of neurology. 68(3)
A study was undertaken to establish an enzyme-linked immunosorbent assay (ELISA) to detect JC virus (JCV)-specific antibodies in multiple sclerosis (MS) patients, and to evaluate its potential utility for identifying patients at higher or lower risk
Autor:
Brian Schlain
Publikováno v:
Clinical chemistry. 44(4)
A new procedure is provided for transferring analyte concentration values from a reference material to production calibrators. This method is robust to calibration curve-fitting errors and can be accomplished using only one instrument and one set of
Autor:
Brian Schlain, Jan S. Krouwer
Publikováno v:
Clinical Chemistry. 40:1785-1786
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