Výsledky vyhledávání - "Brian, Reguly"

Mitochondrial DNA deletions accurately detect endometriosis in symptomatic females of child-bearing age

Autor: Andrew Harbottle, Andrea Maggrah, Brian Reguly, Jennifer Creed

Publikováno v: Biomarkers in Medicine. 13:291-306

Aim: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated mitochondrial DNA deletions as potential biomarkers for endometriosis. Methods: The diagnostic accuracy of deletions was evaluated by quantitative polymerase chain r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08db4db49cf61ac6d025ce8e3b7bff2c
https://doi.org/10.2217/bmm-2018-0419

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A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA 'grey zone'

Autor: Vincent Gnanapragasm, Andrew Harbottle, Jennifer Creed, Anne George, Andrea Maggrah, Laurence Klotz, Brian Reguly

Publikováno v: World Journal of Urology

Purpose To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the ‘grey zone’ (PSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc78cb8727c40674c73af70ae89082e4

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Paired Ductal CarcinomaIn Situand Invasive Breast Cancer Lesions in the D-Loop of the Mitochondrial Genome Indicate a Cancerization Field Effect

Autor: K Gehman, MK Froberg, T Gehman, Andrew Harbottle, H Brown, Andrea Maggrah, Ryan Parr, Jennifer Creed, Kerry Robinson, D Klein, Roy Wittock, Brian Reguly

Publikováno v: BioMed Research International
BioMed Research International, Vol 2013 (2013)

Alterations in the mitochondrial genome have been chronicled in most solid tumors, including breast cancer. The intent of this paper is to compare and document somatic mitochondrial D-loop mutations in paired samples of ductal carcinomain situ(DCIS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca9a1774a655cba42341402d0b8a071
https://doi.org/10.1155/2013/379438

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Mitochondria, prostate cancer, and biopsy sampling error

Autor: Ryan L, Parr, John, Mills, Andrew, Harbottle, Jennifer M, Creed, Gregory, Crewdson, Brian, Reguly, François S, Guimont

Publikováno v: Discovery medicine. 15(83)

Mitochondria and their associated genome are emerging as sophisticated indicators of prostate cancer biology. Alterations in the mitochondrial genome (mtgenome) have been implicated in cell proliferation, metastatic behavior, androgen independence, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d60f1f3d034cc6d2b547c4193b1aef6b
https://pubmed.ncbi.nlm.nih.gov/23636138

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Accurate prediction of repeat prostate biopsy outcomes by a mitochondrial DNA deletion assay

Autor: Kerry Robinson, Ryan Parr, Roy Wittock, C Powell, Jennifer Creed, Brian Reguly, D Klein, Gabriel D. Dakubo, Andrea Maggrah, Laurence Klotz

Publikováno v: Prostate cancer and prostatic diseases. 13(2)

Several cancers are characterized by large-scale mtDNA deletions. We previously provided evidence that one of these deletions has potential utility in resolving false from true-negative prostate needle biopsies. This study was to assess the clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115f8cde78cc45c07731cbd80f8ad0ff
https://pubmed.ncbi.nlm.nih.gov/20084081

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Facile whole mitochondrial genome resequencing from nipple aspirate fluid using MitoChip v2.0

Autor: Kenneth E. Gehman, Paul D. Wagner, Teresa Gehman, Robert Thayer, Sudhir Srivastava, Kerry Robinson, Roy Wittock, Samantha Maragh, Alioune Ngom, Andrea Maggrah, Jennifer Maki, Ryan Parr, Katrina Maki, Gabriel D. Dakubo, John P. Jakupciak, Brian Reguly

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 95 (2008)
BMC Cancer

Background Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from symptomatic women could potentially serve as a minimally invasive sample for breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b942df466c7f111165be7e55aa424eaa
https://doi.org/10.1186/1471-2407-8-95

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Mitochondrial genome deletion aids in the identification of false- and true-negative prostate needle core biopsy specimens

Autor: Ryan Parr, Jude Alexander, Robert Thayer, Brian Reguly, Nicholas Escott, Kerry Robinson, Anthony Skehan, Roy Wittock, Jennifer Maki, Andrea Aguirre, Paul D. Wagner, Samantha Maragh, Eleftherios P. Diamandis, Sudhir Srivastava, Gabriel D. Dakubo, John P. Jakupciak, Owen Prowse, Michael J. Wilson, M. Kent Froberg

Publikováno v: American journal of clinical pathology. 129(1)

We report the usefulness of a 3.4-kb mitochondrial genome deletion (3.4 mtdelta) for molecular definition of benign, malignant, and proximal to malignant (PTM) prostate needle biopsy specimens. The 3.4 mtdelta was identified through long-extension po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280adfde6bfc682de99a5400ee3ed873
https://pubmed.ncbi.nlm.nih.gov/18089489

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Somatic mitochondrial DNA mutations in prostate cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant histology

Autor: Ryan Parr, Eleftherios P. Diamandis, Mamdouh Abdel-Malak, M. Kent Froberg, Brian Reguly, Jennifer Maki, Roy Wittock, Andrea Aguirre, Kerry Robinson, Gabriel D. Dakubo, Mark A. Birch-Machin, Keith A. Crandall, Jude Alexander, Robert Thayer

Publikováno v: The Journal of molecular diagnostics : JMD. 8(3)

Studies of somatic mitochondrial DNA mutations have become an important aspect of cancer research because these mutations might have functional significance and/or serve as a biosensor for tumor detection. Here we report somatic mitochondrial DNA mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41771904d257bc87a2fc4bf426e5feb7
https://pubmed.ncbi.nlm.nih.gov/16825503

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