Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Brian, Metcalf"'
Autor:
David M. Burns, Chunhong He, Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Lihua Chen, Ravi Jalluri, Sharon Diamond, Maryanne B. Covington, Yanlong Li, Richard Wynn, Peggy Scherle, Swamy Yeleswaram, Gregory Hollis, Steve Friedman, Brian Metcalf, Wenqing Yao
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues, resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbafe40c80b68974928f2b0a5dbd9bd
https://pubmed.ncbi.nlm.nih.gov/35835377
https://pubmed.ncbi.nlm.nih.gov/35835377
Autor:
Colin, Zhang, Meizhong, Xu, Chunhong, He, Jincong, Zhuo, David M, Burns, Ding-Quan, Qian, Qiyan, Lin, Yun-Long, Li, Lihua, Chen, Eric, Shi, Costas, Agrios, Linkai, Weng, Vaqar, Sharief, Ravi, Jalluri, Yanlong, Li, Peggy, Scherle, Sharon, Diamond, Deborah, Hunter, Maryanne, Covington, Cindy, Marando, Richard, Wynn, Kamna, Katiyar, Nancy, Contel, Kris, Vaddi, Swamy, Yeleswaram, Gregory, Hollis, Reid, Huber, Steve, Friedman, Brian, Metcalf, Wenqing, Yao
Publikováno v:
SSRN Electronic Journal.
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120
https://doi.org/10.2139/ssrn.4056120
Autor:
Niu, Shin, Matthew, Stubbs, Holly, Koblish, Eddy W, Yue, Maxim, Soloviev, Brent, Douty, Kathy He, Wang, Qian, Wang, Mingming, Gao, Patricia, Feldman, Gengjie, Yang, Leslie, Hall, Michael, Hansbury, Sybil, O'Connor, Lynn, Leffet, Robert, Collins, Kamna, Katiyar, Xin, He, Paul, Waeltz, Paul, Collier, Jin, Lu, Yun-Long, Li, Yanlong, Li, Phillip C C, Liu, Timothy, Burn, Maryanne, Covington, Sharon, Diamond, Dana, Shuey, Alan, Roberts, Swamy, Yeleswaram, Greg, Hollis, Brian, Metcalf, Wenqing, Yao, Reid, Huber, Andrew, Combs, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(1)
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14a526e7b4c814d8f260a1bead68f92f
https://pubmed.ncbi.nlm.nih.gov/32345620
https://pubmed.ncbi.nlm.nih.gov/32345620
Publikováno v:
International Business & Economics Research Journal
The impact Walt Disney’s animated film Frozen is having on Disney’s bottom line and on tourism within Norway is highlighted. Although Frozen takes place in fictional Arendelle, movie producers incorporated Norwegian inspired scenery, imagery, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79674ad0fa94cb6e2a3831be9b6640ea
https://doi.org/10.19030/iber.v17i2.10144
https://doi.org/10.19030/iber.v17i2.10144
Autor:
Brian Metcalf, Cathrine Linnes
Publikováno v:
International Journal of Management & Information Systems (IJMIS). 21:11-26
Technology is becoming increasingly embedded into our lives. We are seeing a push towards digitization and online access. This can be a challenge for some because users’ level of technical ability varies among the generations and other factors. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4561913705db1e35ee0621b79a8f28
https://doi.org/10.19030/ijmis.v21i2.10073
https://doi.org/10.19030/ijmis.v21i2.10073
Autor:
Brian M. Glass, Padmaja Polam, Tom Emm, Kevin Bowman, Jordan S. Fridman, Holly Koblish, Richard Wynn, Michael Hansbury, Yanlong Li, Eddy W. Yue, Brian Metcalf, Michael J. Bower, Min Wei, Richard B. Sparks, Peggy Scherle, Xiangdong Liu, Andrew P. Combs, Timothy Burn, Dilip P. Modi, Brian Wayland, Qian Wang, Lynn Leffet, Brent Douty, Wenyu Zhu, Amy Takvorian, Joseph Glenn
Publikováno v:
ACS Medicinal Chemistry Letters
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e3f5ea28d700b9b9ea48bc68260b0
http://europepmc.org/articles/PMC5430407
http://europepmc.org/articles/PMC5430407
Publikováno v:
Medicinal Chemistry Reviews ISBN: 9780996293280
Medicinal Chemistry Reviews
Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c471a62519dc6849d1be09a713fcdc9a
https://doi.org/10.29200/acsmedchemrev-v54.ch2
https://doi.org/10.29200/acsmedchemrev-v54.ch2
Autor:
Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (20, parsaclisib). The unique structure of 20 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb077aa93316c89804bca15aea78a20
https://pubmed.ncbi.nlm.nih.gov/31749910
https://pubmed.ncbi.nlm.nih.gov/31749910
Autor:
Brian Metcalf, Abel Silva-Garcia, Rebeca M. Choy, Zhe Li, James R. Partridge, Chul Yu, Hing Sham
Publikováno v:
Journal of structural biology. 206(2)
Plasma kallikrein (pKal) is a serine protease responsible for cleaving high-molecular-weight kininogen to produce the pro-inflammatory peptide, bradykinin. Unregulated pKal activity can lead to hereditary angioedema (HAE) following excess bradykinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf88af62441dec56e6f6e2c4f69b8c55
https://pubmed.ncbi.nlm.nih.gov/30876891
https://pubmed.ncbi.nlm.nih.gov/30876891