Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Brian, Meehan"'
Autor:
Cristiana Spinelli, Lata Adnani, Brian Meehan, Laura Montermini, Sidong Huang, Minjun Kim, Tamiko Nishimura, Sidney E. Croul, Ichiro Nakano, Yasser Riazalhosseini, Janusz Rak
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Targeting neovascularization in glioblastoma (GBM) is hampered by poor understanding of the underlying mechanisms and unclear linkages to tumour molecular landscapes. Here we report that different molecular subtypes of human glioma stem cell
Externí odkaz:
https://doaj.org/article/5f16d7dd93a34bec93a7e29368874678
Autor:
Lata Adnani, Jordan Kassouf, Brian Meehan, Cristiana Spinelli, Nadim Tawil, Ichiro Nakano, Janusz Rak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Glioma stem-like cells (GSCs) exhibit plasticity during proneural-to-mesenchymal transition. Here the authors show that extracellular vesicles from endothelial cells can promote this transition of GSCs through activation of MMPs and NFkB, and inactiv
Externí odkaz:
https://doaj.org/article/9fc37250e87a4721843dcf75d51a9476
Autor:
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
SMARCA4/2 loss in ovarian and lung cancers is associated with chemotherapy resistance. Here, the authors show that SMARCA4/2 deficiency in cancer cells reduces the expression of the ER-Ca2+ channel IP3R3 and subsequently calcium transfer to the mitoc
Externí odkaz:
https://doaj.org/article/bf575d4233b14e5f997658655553d914
Autor:
Dongsic Choi, Nargis Khan, Laura Montermini, Nadim Tawil, Brian Meehan, Dae‐Kyum Kim, Frederick P. Roth, Maziar Divangahi, Janusz Rak
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 10, Pp n/a-n/a (2022)
Abstract SARS‐CoV‐2 viral infection led to the devastating COVID‐19 pandemic, where illness stemmed from interactions between virions and recipient host cells resulting in multi‐layered pathological consequences. The role of the infection por
Externí odkaz:
https://doaj.org/article/7db91fd7ef3743dfb7dfa04d6a83b2c6
Autor:
Yibo Xue, Jordan L. Morris, Kangning Yang, Zheng Fu, Xianbing Zhu, Fraser Johnson, Brian Meehan, Leora Witkowski, Amber Yasmeen, Tunde Golenar, Mackenzie Coatham, Geneviève Morin, Anie Monast, Virginie Pilon, Pierre Olivier Fiset, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Lili Fu, Lynne-Marie Postovit, Jonathan Spicer, Walter H. Gotlieb, Marie-Christine Guiot, Janusz Rak, Morag Park, William Lockwood, William D. Foulkes, Julien Prudent, Sidong Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/dd155e5301354bdea1495ad9acd130d1
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 8, Pp n/a-n/a (2021)
Abstract Oncogenic RAS impacts communication between cancer cells and their microenvironment, but it is unclear how this process influences cellular interactions with extracellular vesicles (EVs). This is important as intercellular EV trafficking pla
Externí odkaz:
https://doaj.org/article/9e9bde0caef042a5be1a15e179a933fe
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Olivier Fiset, Ralf Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther Herpel, Sriram Venneti, Daniel Martinez, Alexander R. Judkins, Sungmi Jung, Sophie Camilleri-Broet, Anne V. Gonzalez, Marie-Christine Guiot, William W. Lockwood, Jonathan D. Spicer, Abbas Agaimy, William A. Pastor, Josée Dostie, Janusz Rak, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 express
Externí odkaz:
https://doaj.org/article/f919a450f672493c812a00c6c5045ab6
Autor:
Paul Daniel, Siham Sabri, Ahmad Chaddad, Brian Meehan, Bertrand Jean-Claude, Janusz Rak, Bassam S. Abdulkarim
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Glioma are the most common type of malignant brain tumor, with glioblastoma (GBM) representing the most common and most lethal type of glioma. Surgical resection followed by radiotherapy and chemotherapy using the alkylating agent Temozolomide (TMZ)
Externí odkaz:
https://doaj.org/article/11365748e5fb420c90b63cf3529b6f11
Autor:
Siham Sabri, Bertrand Jean-Claude, Marie-Christine Guiot, Kevin Petrecca, Heather M. Duncan, Kolja Eppert, Nidia Lauzon, Julie Schmitt, Paul Daniel, Janusz Rak, Brian Meehan, Bassam Abdulkarim, Zeinab Sharifi
Table S2 summarizes IC50s of TMZ, gefitinib or ZR2002 for various GSCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c4de5f08c4018da23d11fe7fb26034
https://doi.org/10.1158/1078-0432.22472120.v1
https://doi.org/10.1158/1078-0432.22472120.v1
