Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Brian, Madeira"'
Autor:
Tak W. Mak, Xin Wei, Guodong Mao, Grace Ng, Richard Brokx, Dan Chi-Chia Lin, Graham C. Fletcher, Miklos Feher, Olga Plotnikova, Richard J. Hodgson, Radoslaw Laufer, Henry W. Pauls, Jacqueline M. Mason, Yunhui Lang, Brian Madeira, Irina Beletskaya, Sze-Wan Li, Yong Liu, Yi Che, Donald E. Awrey, Reza Kiarash, Mark R. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3562-3566
TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers. Herein we report the discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba09af33425cf05a065bc4b1c08a55bc
https://doi.org/10.1016/j.bmcl.2016.06.021
https://doi.org/10.1016/j.bmcl.2016.06.021
Autor:
Peter B. Sampson, Yong Liu, Bryan Forrest, Graham Cumming, Sze-Wan Li, Narendra Kumar Patel, Louise Edwards, Radoslaw Laufer, Miklos Feher, Fuqiang Ban, Donald E. Awrey, Guodong Mao, Olga Plotnikova, Richard Hodgson, Irina Beletskaya, Jacqueline M. Mason, Xunyi Luo, Vincent Nadeem, Xin Wei, Reza Kiarash, Brian Madeira, Ping Huang, Tak W. Mak, Guohua Pan, Henry W. Pauls
Publikováno v:
Journal of Medicinal Chemistry. 58:147-169
Previous publications from our laboratory have introduced novel inhibitors of Polo-like kinase 4 (PLK4), a mitotic kinase identified as a potential target for cancer therapy. The search for potent and selective PLK4 inhibitors yielded (E)-3-((1H-inda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a88499af90e226793ff88203ec36fb
https://doi.org/10.1021/jm5005336
https://doi.org/10.1021/jm5005336
Autor:
Yunhui Lang, Louise Edwards, Radoslaw Laufer, Yi Che, Dan Chi-Chia Lin, Yong Liu, Bryan T. Forrest, Sze-Wan Li, Mark R. Bray, Tak W. Mak, Narendra Kumar B. Patel, Xin Wei, Henry W. Pauls, Nickolay Y. Chirgadze, Reza Kiarash, Wei Qiu, Olga Plotnikova, Brian Madeira, Graham C. Fletcher, Richard J. Hodgson, Fuqiang Ban, Miklos Feher, Guodong Mao, Grace Ng, Irina Beletskaya, Donald E. Awrey, Jacqueline M. Mason, Peter Brent Sampson
Publikováno v:
Journal of medicinal chemistry. 58(8)
The acetamido and carboxamido substituted 3-(1H-indazol-3-yl)benzenesulfonamides are potent TTK inhibitors. However, they display modest ability to attenuate cancer cell growth; their physicochemical properties, and attendant pharmacokinetic paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a417f7f080d3add29660da28a0bca0d4
https://pubmed.ncbi.nlm.nih.gov/25763473
https://pubmed.ncbi.nlm.nih.gov/25763473
Autor:
Peter B, Sampson, Yong, Liu, Bryan, Forrest, Graham, Cumming, Sze-Wan, Li, Narendra Kumar, Patel, Louise, Edwards, Radoslaw, Laufer, Miklos, Feher, Fuqiang, Ban, Donald E, Awrey, Guodong, Mao, Olga, Plotnikova, Richard, Hodgson, Irina, Beletskaya, Jacqueline M, Mason, Xunyi, Luo, Vincent, Nadeem, Xin, Wei, Reza, Kiarash, Brian, Madeira, Ping, Huang, Tak W, Mak, Guohua, Pan, Henry W, Pauls
Publikováno v:
Journal of medicinal chemistry. 58(1)
Previous publications from our laboratory have introduced novel inhibitors of Polo-like kinase 4 (PLK4), a mitotic kinase identified as a potential target for cancer therapy. The search for potent and selective PLK4 inhibitors yielded (E)-3-((1Hindaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::160efe8c1bbad6cc1acf1625e82022f2
https://pubmed.ncbi.nlm.nih.gov/25723005
https://pubmed.ncbi.nlm.nih.gov/25723005