Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Brian, Huntly"'
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2233-2261 (2024)
Abstract We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in >90% of colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pre-B-ALL t
Externí odkaz:
https://doaj.org/article/4df981d9b6cb481e9115536caaf2c410
Autor:
Elizabeth Macintyre, Konstanze Döhner, Kirsten Grønbæk, Martin Dreyling, Brian Huntly, Antonio Almeida, John Gribben, for the EHA Board
Publikováno v:
HemaSphere, Vol 8, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/8d0713caac364b5c80e46cfd7b31aac0
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Chrysa Kapeni, Eilidh Rivers, Carolin M Sauer, Flavio Beke, Stephen J Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Ghodsinia, Changtai Li, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E Richardson, Brian Huntly, David R Spring, Mikkel-Ole Skjoedt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 3026-3026 (2024)
Externí odkaz:
https://doaj.org/article/de85458260f0462188f26c6b70c4d232
Autor:
Aleksandra Kamizela, Nicholas Williams, Joe Lee, Karim Mane, Kate Milne, Tony Green, Timothy Chevassut, Brian Huntly, E. Joanna Baxter, Jyoti Nangalia
Publikováno v:
HemaSphere, Vol 7, p e82325b5 (2023)
Externí odkaz:
https://doaj.org/article/15786b79c5f34ba6872f1edc79b90809
Autor:
Barbara Kiesewetter, Urania Dafni, Elisabeth G E de Vries, Jorge Barriuso, Giuseppe Curigliano, Veronica González-Calle, Martina Galotti, Bishal Gyawali, Brian Huntly, Ulrich Jaeger, Nicola Jane Latino, Luca Malcovati, Sjoukje Oosting, Gert Ossenkoppele, Martine Piccart, Markus Raderer, Lydia Scarfò, Dario Trapani, Christoph C Zielinski, Ruth Wester, Panagiota Zygoura, Elizabeth Macintyre, Nathan I Cherny
Publikováno v:
HemaSphere, Vol 7, p e02308e3 (2023)
Externí odkaz:
https://doaj.org/article/fbaa6acb8eac44379781acba442210b6
Autor:
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. Bannister, Roland Rad, Rab K. Prinjha, John C. Marioni, Brian Huntly, Jennifer Batson, Jonathan C. Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O. Bates, Kosuke Yusa, Tony Kouzarides, George S. Vassiliou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects speci
Externí odkaz:
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581
Autor:
Katharina M Lang, Tamás Bereczky, Jan Geissler, Natacha Bolanos, Kathryn E. Morgan, Ananda Plate, Ana Vallejo, Sophie Wintrich, Nick York, Peter Loffelhardt, Brian Huntly, Pieter Sonneveld, Mario Boccadoro, Valeria Santini, Šárka Pospíšilová, Andreas Hochhaus, Tiziano Barbui, Peter Borchmann, Christian Buske, Yann Guillevic, Frederico Calado, Katy Harrison, Dalia Dawoud, Guillermo Sanz, Jesús María Hernández, Ellen De Waal, Martje Barbus, Renate Schulze-Rath, Lars Bullinger
Publikováno v:
Blood. 140:5285-5287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579bedf7830ed534db6b57af73704c1e
https://doi.org/10.1182/blood-2022-157549
https://doi.org/10.1182/blood-2022-157549
Autor:
Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise O’Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger, Inti Zlobec, Ioana Olan, Sarah J. Aitken, Matthew Hoare, Richard Mair, Eva Serrao, James D Brenton, Alicia Garcia-Gimenez, Simon E. Richardson, Brian Huntly, David R. Spring, Mikkel-Ole Skjødt, Karsten Skjødt, Marc de la Roche, Maike de la Roche
Leucine-rich repeat-containing G-protein receptor 5 (LGR5) has been characterised as a stem cell and cancer stem cell marker. Previous analyses of LGR5 transcript levels indicate high level expression discriminates malignancies such as colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b063d90b569482f715ab1d8ee2f0ad58
https://doi.org/10.1101/2022.09.01.506182
https://doi.org/10.1101/2022.09.01.506182
Autor:
Nisha Narayan, Brian Huntly
Publikováno v:
Science Signaling. 15
Mutations in multiple cancers may synergize to alter the cellular epigenetic and transcriptional state and corrupt key signaling pathways. In this issue of Science Signaling , Pedicona et al. illustrate how the two processes intersect to regulate cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b232ab41c76fcc76ad65ee5aadcc38be
https://doi.org/10.1126/scisignal.abo0059
https://doi.org/10.1126/scisignal.abo0059
Autor:
Brian Huntly
Publikováno v:
Cancer Research. 82:IA006-IA006
Interactions between transcription factors (TF) and chromatin factors (CF) regulate gene expression programmes to determine cellular fate. However, unlike for TF, the exact role of CF in this process is poorly understood. Using haematopoiesis as a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9587c6a5fb656d0108581706d12b62
https://doi.org/10.1158/1538-7445.cancepi22-ia006
https://doi.org/10.1158/1538-7445.cancepi22-ia006