Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Brian, Goetz"'
Autor:
Clay T. Cramer, Brian Goetz, Krista L.M. Hopson, Gregory J. Fici, Rose M. Ackermann, Stephen C. Brown, Charles L. Bisgaier, W.G. Rajeswaran, Daniela C. Oniciu, Michael E. Pape
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel ω-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fatty
Externí odkaz:
https://doaj.org/article/6e66dc604caa440cad0b2da77bb5ad67
Autor:
Li Ding, Minjung Kim, Krishna L Kanchi, Nathan D Dees, Charles Lu, Malachi Griffith, David Fenstermacher, Hyeran Sung, Christopher A Miller, Brian Goetz, Michael C Wendl, Obi Griffith, Lynn A Cornelius, Gerald P Linette, Joshua F McMichael, Vernon K Sondak, Ryan C Fields, Timothy J Ley, James J Mulé, Richard K Wilson, Jeffrey S Weber
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111153 (2014)
To reveal the clonal architecture of melanoma and associated driver mutations, whole genome sequencing (WGS) and targeted extension sequencing were used to characterize 124 melanoma cases. Significantly mutated gene analysis using 13 WGS cases and 15
Externí odkaz:
https://doaj.org/article/1291a159fc7042a19c0e538ea5ad494d
Akademický článek
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Publikováno v:
Proceedings of the VLDB Endowment. 7:1343-1354
With the addition of lambda expressions and the Stream API in Java 8, Java has gained a powerful and expressive query language that operates over in-memory collections of Java objects, making the transformation and analysis of data more convenient, s
Autor:
Lianhao Zhang, Ralf Mueller, Michael E. Pape, Andrew McKee, Eelco J. Ebbers, Charles L. Bisgaier, Bruce H. McCosar, Jean-Louis H Dasseux, Clay T. Cramer, Dennis Smith, Mike Relou, Henk Regeling, Emil Pop, B.R. Krause, Frank M. C. Leemhuis, Roel P.L. Bell, Dennis Verdijk, Brian Goetz, Daniela Carmen Oniciu
Publikováno v:
Synthetic Communications. 36:365-391
A series of pantolactone and pantothenic acid derivatives (1–10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme‐A mimics. The syntheses were performed with moderate to high yields.
Autor:
Roel P L, Bell, Dennis, Verdijk, Mike, Relou, Dennis, Smith, Henk, Regeling, Eelco J, Ebbers, Frank M C, Leemhuis, Daniela C, Oniciu, Clay T, Cramer, Brian, Goetz, Michael E, Pape, Brian R, Krause, Charles L, Bisgaier, Jean-Louis, Dasseux
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:223-236
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on
Autor:
Daniela C. Oniciu, Sergey Denisenko, Ralf Mueller, Charles L Bisgaier, Krista L Hopson, Bruce H McCosar, Tian-Bao Huang, Lian Hao Zhang, Brian Goetz, Caiming Duan, Jing Yang, Clay T Cramer, Catherine Delaney Freiman, Jean-Louis H Dasseux, Otto J Geoffroy, Michael E Pape, Emil Pop
Publikováno v:
Journal of Medicinal Chemistry. 47:6082-6099
Keto-substituted hydrocarbons with 11-19 methylene and bis-terminal hydroxyl and carboxyl groups have been synthesized and evaluated in both in vivo and in vitro assays for their potential to favorably alter lipid disorders including metabolic syndro
Autor:
Anna Denisenko, Ralf Mueller, Catherine Delaney Freiman, Emil Pop, Krista L Hopson, Charles L Bisgaier, Tian-Bao Huang, Daniela C. Oniciu, Lian Hao Zhang, Brian Goetz, Jing Yang, Olga V Denisko, Jean-Louis H Dasseux, Michael E Pape, Caiming Duan, Clay T Cramer
Publikováno v:
Journal of Medicinal Chemistry. 47:5183-5197
Long hydrocarbon chain ethers with bis-terminal hydroxyl or carboxyl groups have been synthesized and evaluated for their potential to favorably alter lipid disorders including metabolic syndrome. Compounds were assessed for their effects on the de n
Autor:
Rose Ackermann, Gregory J. Fici, Brian Goetz, Krista L.M. Hopson, Michael E. Pape, Daniela C. Oniciu, Stephen C. Brown, Clay T. Cramer, W.G. Rajeswaran, Charles L. Bisgaier
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1289-1301 (2004)
We have identified a novel omega-hydroxy-alkanedicarboxylic acid, ESP 55016, that favorably alters serum lipid variables in obese female Zucker (fa/fa) rats. ESP 55016 reduced serum non-HDL-cholesterol (non-HDL-C), triglyceride, and nonesterified fat
Publikováno v:
Proceedings of the ACM international conference companion on Object oriented programming systems languages and applications companion.