Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Brian, Dalley"'
Autor:
Arun Jyothidasan, Sini Sunny, Asokan Devarajan, Aniqa Sayed, John Kofi Afortude, Brian Dalley, Vivek Nanda, Steven Pogwizd, Silvio H. Litovsky, Joel D. Trinity, Matthew Might, Namakkal S. Rajasekaran
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103263- (2024)
The endoplasmic reticulum (ER) regulates protein folding and maintains proteostasis in cells. We observed that the ER transcriptome is impaired during chronic reductive stress (RS) in cardiomyocytes. Here, we hypothesized that a prolonged moderate tr
Externí odkaz:
https://doaj.org/article/89d8b21237c04432b90821ae7822b5b0
Autor:
Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende, Namakkal S. Rajasekaran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the progressive loss of cardiac function that manifests as heart failure. Nuclear factor, er
Externí odkaz:
https://doaj.org/article/0bacb871034845faa009f27435e581fe
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Histone deacetylase (HDAC) inhibition has sporadic clinical efficacy in urothelial carcinoma; the genomic basis for clinical response is not known. In two separate phase I clinical trials testing pharmacokinetic aspects of HDAC inhibitors in advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4e1e38652dd7a79529d4ba01a40db4
https://doi.org/10.1158/1535-7163.c.6537834.v1
https://doi.org/10.1158/1535-7163.c.6537834.v1
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
GSEA with Hallmark gene sets performed on transcriptional changes in HT1197 cells treated with panobinostat for 48 hours. A. Top 6 downregulated GSEA signatures B. Top 6 upregulated GSEA signatures C. GSEA HT1197 vs UMUC3 ( comparison of transcriptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3dc70c008073ca019badbdc66ba909
https://doi.org/10.1158/1535-7163.22504713
https://doi.org/10.1158/1535-7163.22504713
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Heat map of top 50 genes affected in HT1197 cells when treated with panobinostat at 48 hours log2 gene expression change(HT1197 A-B and C represent control replicates, HT1197 Pano A, B, C represent treated replicates). For the cell lines with replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a56af42c97fabe3bfcd48fef55e9f8
https://doi.org/10.1158/1535-7163.22504722
https://doi.org/10.1158/1535-7163.22504722
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Individual drug characteristics and doses, maximum plasma levels and protein binding of panobinostat and belinostat in the two phase 1 studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881bc6ec7f2724358ba7b34045aa5295
https://doi.org/10.1158/1535-7163.22504716
https://doi.org/10.1158/1535-7163.22504716
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Study Schema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d03082dfc96e6a789b51e7093790f38
https://doi.org/10.1158/1535-7163.22504728.v1
https://doi.org/10.1158/1535-7163.22504728.v1
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Swimmer Plot to show the best overall response and duration of benefit in seven bladder cancer patients from Table 1 treated with HDAC inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abb7b29048342a29e3e1e00fea1a0e2
https://doi.org/10.1158/1535-7163.22504725.v1
https://doi.org/10.1158/1535-7163.22504725.v1
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Demographic and clinical characteristics of patients treated with belinostat and panobinostat with archived tumor tissue available for study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c198553b1a7942eb81be0ac158350da0
https://doi.org/10.1158/1535-7163.22504719.v1
https://doi.org/10.1158/1535-7163.22504719.v1
Autor:
Sini Sunny, Namakkal S. Rajasekaran, Justin M. Quiles, Adam R. Wende, Sandeep B. Shelar, Steven M. Pogwizd, John R. Hoidal, Brian Dalley, Mark E Pepin, Anil K. Challa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the progressive loss of cardiac function that manifests as heart failure. Nuclear factor, erythroid 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2a800252cdf9a1b96daebc480b9d68
https://doaj.org/article/0bacb871034845faa009f27435e581fe
https://doaj.org/article/0bacb871034845faa009f27435e581fe