Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Brian, Becknell"'
Autor:
Hanna Cortado, Macie Kercsmar, Birong Li, Gabriela Vasquez-Martinez, Sudipti Gupta, Christina Ching, Gregory Ballash, Israel Cotzomi-Ortega, Yuriko I. Sanchez-Zamora, Ester Boix, Diana Zepeda-Orozco, Ashley R. Jackson, John David Spencer, Juan de Dios Ruiz-Rosado, Brian Becknell
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 283-294 (2024)
Introduction: The ribonuclease (RNase) A superfamily encodes cationic antimicrobial proteins with potent microbicidal activity toward uropathogenic bacteria. Ribonuclease 6 (RNase6) is an evolutionarily conserved, leukocyte-derived antimicrobial pept
Externí odkaz:
https://doaj.org/article/ac88fb78e53143a2873331164377a529
Autor:
Maria Jebbia, Sudipti Gupta, Brett G. Klamer, Leeann Pavlek, Christina B. Ching, Tahagod H. Mohamed, Brian Becknell
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-5 (2024)
Abstract Urinary tract infections (UTIs) are a common comorbidity in hospitalized neonates. The current UTI diagnostics have several limitations including invasive collection of urinary samples to ensure sterility, risk of contamination and lack of c
Externí odkaz:
https://doaj.org/article/335695c562e2472ba1a6de92d4f6792f
Autor:
Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R. Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spencer
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114007- (2024)
Summary: Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) sh
Externí odkaz:
https://doaj.org/article/26705d777a114915af5c25ba310213b6
Autor:
Juan de Dios Ruiz-Rosado, Hanna Cortado, Macie Kercsmar, Birong Li, Gregory Ballash, Israel Cotzomi-Ortega, Yuriko I. Sanchez-Zamora, Sudipti Gupta, Christina Ching, Ester Boix, Ashley R. Jackson, John David Spencer, Brian Becknell
Publikováno v:
Journal of Innate Immunity, Vol 15, Iss 1, Pp 865-875 (2023)
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to the RNase A superfamily have a critical role in defending the bladder and kidney from bacterial infection. RNase 6 has been identified as a potent, leukocyte-deri
Externí odkaz:
https://doaj.org/article/e1aa234377314638a307a986e4aae03d
Autor:
Claire Bryant, Galen Rask, Amanda P. Waller, Amy Webb, Marina R. Galdino-Pitta, Angelica A. Amato, Rachel Cianciolo, Rajgopal Govindarajan, Brian Becknell, Bryce A. Kerlin, Francisco A.R. Neves, Alessia Fornoni, Shipra Agrawal
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104001- (2022)
Summary: Glomerular disease manifests as nephrotic syndrome (NS) with high proteinuria and comorbidities, and is frequently refractory to standard treatments. We hypothesized that a selective modulator of PPARγ, GQ-16, will provide therapeutic advan
Externí odkaz:
https://doaj.org/article/44c5e6b650c949c28445ae97cc0f1fae
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The lower urinary tract is routinely exposed to microbes residing in the gastrointestinal tract, yet the urothelium resists invasive infections by gut microorganisms. This infection resistance is attributed to innate defenses in the bladder urotheliu
Externí odkaz:
https://doaj.org/article/032cf40ad41f4963909143e136d4e2eb
Publikováno v:
Pediatric Nephrology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8364f17d26d95333df01e48181115fd
https://doi.org/10.1007/s00467-023-05992-0
https://doi.org/10.1007/s00467-023-05992-0
Publikováno v:
Pediatric Nephrology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::058dafdbf442dacb52b1037c31c85b6e
https://doi.org/10.1007/s00467-023-05899-w
https://doi.org/10.1007/s00467-023-05899-w
Autor:
Laura Schwartz, M. Skye Bochter, Aaron Simoni, Kristin Bender, Juan de Dios Ruiz Rosado, Israel Cotzomi-Ortega, Yuriko I. Sanchez-Zamora, Brian Becknell, Sarah Linn, Birong Li, Nicholas Santoro, Tad Eichler, John David Spencer
Publikováno v:
Proceedings of the National Academy of Sciences. 120
With the emergence of antibiotic-resistant bacteria, innovative approaches are needed for the treatment of urinary tract infections. Boosting antimicrobial peptide expression may provide an alternative to antibiotics. Here, we developed reporter cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68d22dca0cd7da95dbe11ab8bc6a533
https://doi.org/10.1073/pnas.2213363120
https://doi.org/10.1073/pnas.2213363120
Publikováno v:
Pediatric Nephrology. 37:1721-1731
Urothelium is a specialized multilayer epithelium that lines the urinary tract from the proximal urethra to the kidney. In addition to proliferation and differentiation during development, urothelial injury postnatally triggers a robust regenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdb76ded99d42ee319d672e2a5495e37
https://doi.org/10.1007/s00467-021-05239-w
https://doi.org/10.1007/s00467-021-05239-w