Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

Autor: Brewer, Kathryn R., Kuenze, Georg, Vanoye, Carlos G., George Jr., Alfred L., Meiler, Jens, Sanders, Charles R.

The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (Kv) channels KCNQ1 and hERG

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Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.

Autor: Brewer KR; Center for Structural Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, United States.; Department of Biochemistry, Vanderbilt University, Nashville, TN, United States., Kuenze G; Center for Structural Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, United States.; Department of Chemistry, Vanderbilt University, Nashville, TN, United States., Vanoye CG; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States., George AL Jr; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States., Meiler J; Center for Structural Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, United States.; Department of Chemistry, Vanderbilt University, Nashville, TN, United States.; Department of Pharmacology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, United States.; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany., Sanders CR; Center for Structural Biology, Vanderbilt University School of Medicine Basic Sciences, Nashville, TN, United States.; Department of Biochemistry, Vanderbilt University, Nashville, TN, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2020 May 04; Vol. 11, pp. 550. Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).